Bone From Blood: Characteristics and Clinical Implications of Circulating Osteogenic Progenitor (COP) Cells

Jack Feehan, Moustapha Kassem, Robert J. Pignolo, Gustavo Duque

Research output: Contribution to journalReview articlepeer-review

Abstract

Circulating osteogenic progenitor (COP) cells are a population of cells in the peripheral blood with the capacity for bone formation, as well as broader differentiation into mesoderm-like cells in vitro. Although some of their biological characteristics are documented in vitro, their role in diseases of the musculoskeletal system remains yet to be fully evaluated. In this review, we provide an overview of the role of COP cells in a number of physiological and pathological conditions, as well as identify areas for future research. In addition, we suggest possible areas for clinical utilization in the management of musculoskeletal diseases.

Original languageEnglish (US)
Pages (from-to)12-23
Number of pages12
JournalJournal of Bone and Mineral Research
Volume36
Issue number1
DOIs
StatePublished - Jan 2021

Keywords

  • CIRCULATING OSTEOGENIC PRECURSOR CELLS
  • COP CELLS
  • FRACTURE
  • FRAILTY
  • HETEROTOPIC OSSIFICATION
  • OSTEOPOROSIS
  • VASCULAR CALCIFICATION

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

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