Bone From Blood: Characteristics and Clinical Implications of Circulating Osteogenic Progenitor (COP) Cells

Jack Feehan; Moustapha Kassem; Robert J. Pignolo; Gustavo Duque

doi:10.1002/jbmr.4204

Bone From Blood: Characteristics and Clinical Implications of Circulating Osteogenic Progenitor (COP) Cells

Jack Feehan, Moustapha Kassem, Robert J. Pignolo, Gustavo Duque

Hospital Internal Medicine

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Circulating osteogenic progenitor (COP) cells are a population of cells in the peripheral blood with the capacity for bone formation, as well as broader differentiation into mesoderm-like cells in vitro. Although some of their biological characteristics are documented in vitro, their role in diseases of the musculoskeletal system remains yet to be fully evaluated. In this review, we provide an overview of the role of COP cells in a number of physiological and pathological conditions, as well as identify areas for future research. In addition, we suggest possible areas for clinical utilization in the management of musculoskeletal diseases.

Original language	English (US)
Pages (from-to)	12-23
Number of pages	12
Journal	Journal of Bone and Mineral Research
Volume	36
Issue number	1
DOIs	https://doi.org/10.1002/jbmr.4204
State	Published - Jan 2021

Keywords

CIRCULATING OSTEOGENIC PRECURSOR CELLS
COP CELLS
FRACTURE
FRAILTY
HETEROTOPIC OSSIFICATION
OSTEOPOROSIS
VASCULAR CALCIFICATION

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Orthopedics and Sports Medicine

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10.1002/jbmr.4204

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title = "Bone From Blood: Characteristics and Clinical Implications of Circulating Osteogenic Progenitor (COP) Cells",

abstract = "Circulating osteogenic progenitor (COP) cells are a population of cells in the peripheral blood with the capacity for bone formation, as well as broader differentiation into mesoderm-like cells in vitro. Although some of their biological characteristics are documented in vitro, their role in diseases of the musculoskeletal system remains yet to be fully evaluated. In this review, we provide an overview of the role of COP cells in a number of physiological and pathological conditions, as well as identify areas for future research. In addition, we suggest possible areas for clinical utilization in the management of musculoskeletal diseases.",

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author = "Jack Feehan and Moustapha Kassem and Pignolo, {Robert J.} and Gustavo Duque",

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AU - Feehan, Jack

AU - Kassem, Moustapha

AU - Pignolo, Robert J.

AU - Duque, Gustavo

PY - 2021/1

Y1 - 2021/1

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KW - COP CELLS

KW - FRACTURE

KW - FRAILTY

KW - HETEROTOPIC OSSIFICATION

KW - OSTEOPOROSIS

KW - VASCULAR CALCIFICATION

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Bone From Blood: Characteristics and Clinical Implications of Circulating Osteogenic Progenitor (COP) Cells

Abstract

Keywords

ASJC Scopus subject areas

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