TY - JOUR
T1 - Blood pressure variation in healthy humans
T2 - A possible interaction with β-2 adrenergic receptor genotype and renal epithelial sodium channels
AU - Snyder, Eric M.
AU - Joyner, Michael J.
AU - Turner, Stephen T.
AU - Johnson, Bruce D.
PY - 2005
Y1 - 2005
N2 - Renal control of Na+ regulation is a critical component to blood pressure regulation. It has recently been suggested that the β-2 adrenergic receptor plays a role in blood pressure regulation possibly via renal epithelial sodium channels (ENaC). In the kidneys, gain of function mutations of the ENaC leads to increased salt-sensitivity and hypertension (Liddle's syndrome). In contrast, loss of function mutations of the ENaC leads to pseudohypoaldosteronism and is characterized by hypotension. Polymorphic variation of the β-2 adrenergic receptor (β2AR, the Arg16Gly polymorphism) leads to differences in physiologic function, in vivo. Specifically, subjects homozygous for Glycine at amino acid 16 have been shown to have enhanced forearm blood flow in response to isoproterenol and better airway function at baseline and during exercise when compared to subjects homozygous for Arginine at amino acid 16. We hypothesize, therefore, that subjects that are homozygous for Gly at amino acid 16 of the β2AR have higher baseline blood pressure than Arg16 homozygotes due to β2AR-mediated increases in ENaC activity in the kidney, caused, at least in part, by greater β2AR density or enhanced β2AR function of the Gly16 group.
AB - Renal control of Na+ regulation is a critical component to blood pressure regulation. It has recently been suggested that the β-2 adrenergic receptor plays a role in blood pressure regulation possibly via renal epithelial sodium channels (ENaC). In the kidneys, gain of function mutations of the ENaC leads to increased salt-sensitivity and hypertension (Liddle's syndrome). In contrast, loss of function mutations of the ENaC leads to pseudohypoaldosteronism and is characterized by hypotension. Polymorphic variation of the β-2 adrenergic receptor (β2AR, the Arg16Gly polymorphism) leads to differences in physiologic function, in vivo. Specifically, subjects homozygous for Glycine at amino acid 16 have been shown to have enhanced forearm blood flow in response to isoproterenol and better airway function at baseline and during exercise when compared to subjects homozygous for Arginine at amino acid 16. We hypothesize, therefore, that subjects that are homozygous for Gly at amino acid 16 of the β2AR have higher baseline blood pressure than Arg16 homozygotes due to β2AR-mediated increases in ENaC activity in the kidney, caused, at least in part, by greater β2AR density or enhanced β2AR function of the Gly16 group.
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U2 - 10.1016/j.mehy.2004.12.031
DO - 10.1016/j.mehy.2004.12.031
M3 - Article
C2 - 15922102
AN - SCOPUS:19744378858
SN - 0306-9877
VL - 65
SP - 296
EP - 299
JO - Medical Hypotheses
JF - Medical Hypotheses
IS - 2
ER -