Blood-nerve transfer of albumin and its implications for the endoneurial microenvironment

Ananda Weerasuriya, Geoffry L. Curran, Joseph F. Poduslo

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Blood-nerve transfer of plasma albumin was studied by measuring the permeability coefficient-surface area (PS) product of the blood-nerve barrier (BNB) to 125I-albumin in rat sciatic nerve using the i.v. bolus injection method. The calculated PS was 6.3 ± 0.5 (S.E.M.) × 10-7 ml·g-1·s-1. This value is smaller by more than an order of magnitude of that measured for sucrose and confirms the relative impermeance of the BNB to blood-borne solutes. From a review of the available evidence, it is concluded that normal blood-nerve exchange occurs predominantly across the endoneurial microvasculature, and the PS of the BNB reflects the permeability of capillaries to a greater extent than that of the perineurium. The only capillaries found to be less permeable than these are the cerebral capillaries. Proximo-distal differences (sciatic vs tibial) of the PS could not be detected. Blood-nerve albumin transfer was calculated at 1.2 mg·g-1·day-1, and the daily turnover of endoneurial albumin to be about 30%. It is postulated that small increases in PS of BNB to albumin lead to an elevation of endoneurial albumin concentration and, through the operation of Starling forces, subsequently produce endoneurial oedema. A major question posed by the results of this study is the identity of pathways for clearance of albumin and other macromolecules from the endoneurium.

Original languageEnglish (US)
Pages (from-to)114-121
Number of pages8
JournalBrain Research
Volume494
Issue number1
DOIs
StatePublished - Aug 7 1989

Fingerprint

Nerve Transfer
Blood-Nerve Barrier
Albumins
Peripheral Nerves
Starlings
Capillary Permeability
Sciatic Nerve
Microvessels
Serum Albumin
Sucrose
Permeability
Edema
Injections

Keywords

  • Albumin
  • Blood-nerve barrier
  • Capillary permeability
  • Endoneurial capillary
  • Endoneurium
  • Perineurium
  • Sciatic nerve

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Blood-nerve transfer of albumin and its implications for the endoneurial microenvironment. / Weerasuriya, Ananda; Curran, Geoffry L.; Poduslo, Joseph F.

In: Brain Research, Vol. 494, No. 1, 07.08.1989, p. 114-121.

Research output: Contribution to journalArticle

Weerasuriya, Ananda ; Curran, Geoffry L. ; Poduslo, Joseph F. / Blood-nerve transfer of albumin and its implications for the endoneurial microenvironment. In: Brain Research. 1989 ; Vol. 494, No. 1. pp. 114-121.
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