TY - JOUR
T1 - Biphasic synovial sarcomas arising in the pleural cavity
T2 - A clinicopathologic study of five cases
AU - Gaertner, Erich
AU - Zeren, E. Handan
AU - Fleming, Marian V.
AU - Colby, Thomas V.
AU - Travis, William D.
N1 - Funding Information:
We thank Dr. B. Pepinsky, Dr. B. Seaton, and D. Janssen for their generous gifts of the annexin V cDNA and the pGEF expression vector, respectively. We greatly acknowledge Dr. J. Sop-kova for providing us with an atomic model of annexin V trimer and for the realization of Fig. 3. I.R. is the recipient of a Ubbo Emmius Ph.D. fellowship from the University of Groningen. This work was supported by EC Grants BI04-98-0110 and BI04-98-0543 to A.B.
PY - 1996/1
Y1 - 1996/1
N2 - Five cases of primary synovial sarcoma of the pleura are presented with a discussion of differentiation from other biphasic malignant neoplasms, most notably malignant mesothelioma. The cases have clinical, histologic, and immunohistochemical features consistent with synovial sarcoma of soft tissue. The average age at initial presentation of the reported patients was 25 years with an approximate range of 9 to 50 years. A large pleural-based intrathoracic mass was identified in each case. Histologic analysis showed a biphasic (mixed) pattern composed of epithelial and spindle cells. The epithelial cells showed cleft-like to tubulopapillary growth with focal intraluminal periodic acid Schiff's (PAS)-positive, diastase-resistant secretions identified in four of the five cases. The spindle cell component was composed predominantly of densely packed, elongated, fusiform cells. Immunohistochemical staining showed positivity with antibodies against cytokeratin, BER.EP4, epithelial membrane antigen, and vimentin in all cases. The patients seem to have fin aggressive course, with four deaths reported within 3 years from initial surgery. These cases represent the first reported cases of primary synovial sarcoma of the pleura and lend further credence to the theory that synovial sarcomas are derived from immature mesenchymal elements, not from synovium.
AB - Five cases of primary synovial sarcoma of the pleura are presented with a discussion of differentiation from other biphasic malignant neoplasms, most notably malignant mesothelioma. The cases have clinical, histologic, and immunohistochemical features consistent with synovial sarcoma of soft tissue. The average age at initial presentation of the reported patients was 25 years with an approximate range of 9 to 50 years. A large pleural-based intrathoracic mass was identified in each case. Histologic analysis showed a biphasic (mixed) pattern composed of epithelial and spindle cells. The epithelial cells showed cleft-like to tubulopapillary growth with focal intraluminal periodic acid Schiff's (PAS)-positive, diastase-resistant secretions identified in four of the five cases. The spindle cell component was composed predominantly of densely packed, elongated, fusiform cells. Immunohistochemical staining showed positivity with antibodies against cytokeratin, BER.EP4, epithelial membrane antigen, and vimentin in all cases. The patients seem to have fin aggressive course, with four deaths reported within 3 years from initial surgery. These cases represent the first reported cases of primary synovial sarcoma of the pleura and lend further credence to the theory that synovial sarcomas are derived from immature mesenchymal elements, not from synovium.
KW - Malignant mesothelioma
KW - Pleura
KW - Sarcoma
KW - Synovial sarcoma
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U2 - 10.1097/00000478-199601000-00004
DO - 10.1097/00000478-199601000-00004
M3 - Article
C2 - 8540607
AN - SCOPUS:0030068039
SN - 0147-5185
VL - 20
SP - 36
EP - 45
JO - American Journal of Surgical Pathology
JF - American Journal of Surgical Pathology
IS - 1
ER -