Biophysical properties, efficacy, and lesion characteristics of a new linear cryoablation catheter in a canine model

Atsushi Suzuki, H. Immo Lehmann, Songyun Wang, Kay D. Parker, Maryam E. Rettmann, Kristi H. Monahan, Douglas L. Packer

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The cryoballoon (CB) catheter is an established tool for pulmonary vein isolation (PVI), but its use is limited for that purpose. Objective: The purpose of this study was to investigate the biophysical properties of a newly developed linear cryoablation catheter for creation of linear ablation lesions in an in vivo model. Methods: Twenty-nine dogs (14 acutely ablated, 15 chronically followed) underwent cryoablation using the linear cryoablation catheter. Regions of interest included the cavotricuspid isthmus (CTI), mitral isthmus (MI), left atrial (LA) roof, and LA posterior wall in an acute study. Cryoablations for CTI and MI were performed in 14 atrial fibrillation animals after PVI and followed over 1 month in the chronic study. Tissue temperature during cryoablation was monitored using implanted thermocouples in the regions of interest. Gross and microscopic pathologic characteristics of the lesions were assessed. Results: In acute animals, lesion length (transmurality) was CTI 34 ± 4 mm (89% ± 11%); MI 29 ± 4 mm (90% ± 13%); LA roof 19 ± 3 mm (90% ± 8%); and LA posterior wall 19 ± 2 mm (81% ± 13%), with 1 or 2 freezes. Chronic bidirectional block was achieved in 13 of 14 CTI (93%) and 10 of 14 MI (71%) ablations after 1-month follow-up and was consistent with lesion continuity and transmurality upon pathology. The lowest tissue temperature correlated well with the closest distance to the linear cryocatheter (r = 0.688; P <.001). Conclusion: This linear cryocatheter created continuous and transmural linear lesions with “single-shot” cryoenergy application and has the potential for clinical use in the setting of various arrhythmias.

Original languageEnglish (US)
Pages (from-to)1967-1975
Number of pages9
JournalHeart rhythm
Volume17
Issue number11
DOIs
StatePublished - Nov 2020

Keywords

  • Atrial flutter
  • Atrial tachycardia
  • Cryoenergy ablation
  • Linear ablation catheter
  • Single-shot energy ablation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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