Biomechanical Assessment of the Iris in Relation to Angle-Closure Glaucoma: A Multi-scale Computational Approach

Vineet S. Thomas, Sam D. Salinas, Anup D. Pant, Syril K. Dorairaj, Rouzbeh Amini

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The abnormalities in the iris shape and deformation could cause closure of the space between the iris and cornea. Such closure may lead to development of certain types of glaucoma, a mysterious disease causing irreversible blindness. As such, the mechanical response of the iris and its deformation have been studied extensively in the context of glaucoma. The collagen fibrils of the iris stroma provide support while undergoing continuous large mechanical deformation. The relationship between micrometer-scale and macro-scale mechanical environment, however, remains unknown. We have used a multiscale computational framework, linking the volume-averaged stress in micrometer-scale representative volume elements to a macro-scale finite-element continuum. We fitted the multiscale model response to experimental data obtained from uniaxial tension tests of intact irides. We hope to employ our model in pathophysiological states of the iris to understand how the microscale deformation may differ in glaucomatous eyes as compared to the healthy controls.

Original languageEnglish (US)
Title of host publicationLecture Notes in Computational Vision and Biomechanics
PublisherSpringer
Pages470-482
Number of pages13
DOIs
StatePublished - Jan 1 2020

Publication series

NameLecture Notes in Computational Vision and Biomechanics
Volume36
ISSN (Print)2212-9391
ISSN (Electronic)2212-9413

Keywords

  • Angle-closure glaucoma
  • Iris
  • Multiscale model

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Mechanical Engineering
  • Computer Vision and Pattern Recognition
  • Computer Science Applications
  • Artificial Intelligence

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  • Cite this

    Thomas, V. S., Salinas, S. D., Pant, A. D., Dorairaj, S. K., & Amini, R. (2020). Biomechanical Assessment of the Iris in Relation to Angle-Closure Glaucoma: A Multi-scale Computational Approach. In Lecture Notes in Computational Vision and Biomechanics (pp. 470-482). (Lecture Notes in Computational Vision and Biomechanics; Vol. 36). Springer. https://doi.org/10.1007/978-3-030-43195-2_38