TY - JOUR
T1 - Biomarker tests for risk assessment in coronary artery disease
T2 - Will they change clinical practice?
AU - Mair, Johannes
AU - Jaffe, Allan S.
PY - 2014/2
Y1 - 2014/2
N2 - The clinical significance and economic impact of coronary artery disease has triggered major research efforts into the discovery of novel biomarkers for risk stratification in primary and secondary prevention and then the development of assays suitable for routine measurement. Nevertheless, the clinical impact of these novel biomarkers for risk stratification is still limited because they do not add substantially to traditional risk factors and they only modestly - even with a multimarker approach - improve risk stratification and patient reclassification. The most useful markers appear to be high-sensitivity C-reactive protein, natriuretic peptides, and, eventually, high-sensitivity cardiac troponins. Further research is clearly needed.
AB - The clinical significance and economic impact of coronary artery disease has triggered major research efforts into the discovery of novel biomarkers for risk stratification in primary and secondary prevention and then the development of assays suitable for routine measurement. Nevertheless, the clinical impact of these novel biomarkers for risk stratification is still limited because they do not add substantially to traditional risk factors and they only modestly - even with a multimarker approach - improve risk stratification and patient reclassification. The most useful markers appear to be high-sensitivity C-reactive protein, natriuretic peptides, and, eventually, high-sensitivity cardiac troponins. Further research is clearly needed.
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U2 - 10.1007/s40291-013-0057-0
DO - 10.1007/s40291-013-0057-0
M3 - Article
C2 - 24072397
AN - SCOPUS:84893323236
SN - 1177-1062
VL - 18
SP - 5
EP - 15
JO - Molecular Diagnosis and Therapy
JF - Molecular Diagnosis and Therapy
IS - 1
ER -