Biology and treatment of basal-like breast cancer

Bingchen Han, William Audeh, Yanli Jin, Sanjay P. Bagaria, Xiaojiang Cui

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Breast cancer is one of the most common cancers identified among women worldwide. It is a heterogeneous disease, with each sub-disease displaying unique clinical and histopathologic characteristics. Based on genomic analysis and gene expression profiling, breast cancer has been classified into several distinct subgroups. Estrogen receptor (ER)-positive breast cancers can be treated with antiestrogen drugs such as tamoxifen, and human epidermal growth factor receptor 2 (HER2)-positive breast cancers can be treated with HER2-targeted drugs such as trastuzumab. Because of the low expression of ER and HER2, patients with basal-like breast cancer cannot benefit from these targeted therapies. Thus, to identify and validate pivotal theranostic biomarkers for basal-like breast cancer is of paramount importance. This chapter describes the molecular and histological features of basal-like breast cancer as well as the differences between basal-like breast cancer and the other breast cancer subtypes. It presents current progress in identifying the biomarkers for basal-like breast cancer. It concludes with a description of the current therapeutic strategies to treat basal-like breast cancer and argues that inhibition of basal-like tumor-associated signaling pathways, in conjunction with standard therapies, may enhance the treatment efficacy.

Original languageEnglish (US)
Title of host publicationCell and Molecular Biology of Breast Cancer
PublisherHumana Press Inc.
Pages91-109
Number of pages19
ISBN (Electronic)9781627036344
ISBN (Print)1627036334, 9781627036337
DOIs
StatePublished - Jun 1 2013

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Han, B., Audeh, W., Jin, Y., Bagaria, S. P., & Cui, X. (2013). Biology and treatment of basal-like breast cancer. In Cell and Molecular Biology of Breast Cancer (pp. 91-109). Humana Press Inc.. https://doi.org/10.1007/978-1-62703-634-4_5