TY - JOUR
T1 - Biliary tract physiology
AU - Prall, Richard T.
AU - LaRusso, Nicholas F.
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1999
Y1 - 1999
N2 - Largely because of the recent development of new experimental models, cholangiocytes - the cells lining the bile ducts-are now recognized as important contributors to and modulators of bile formation. Recent work elucidating the mechanisms and regulation of fluid, solute and electrolyte transport indicates that the biliary epithelium influences bile formation through both autocrine and paracrine mechanisms. Novel roles for bile acids in cholangiocyte physiology have been proposed, and insight into the anatomic and functional differences of cholangiocytes along the biliary tree has been gained. Improved understanding of these concepts and the pathophysiologic response of the biliary tree to injury should provide new therapies for biliary diseases.
AB - Largely because of the recent development of new experimental models, cholangiocytes - the cells lining the bile ducts-are now recognized as important contributors to and modulators of bile formation. Recent work elucidating the mechanisms and regulation of fluid, solute and electrolyte transport indicates that the biliary epithelium influences bile formation through both autocrine and paracrine mechanisms. Novel roles for bile acids in cholangiocyte physiology have been proposed, and insight into the anatomic and functional differences of cholangiocytes along the biliary tree has been gained. Improved understanding of these concepts and the pathophysiologic response of the biliary tree to injury should provide new therapies for biliary diseases.
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U2 - 10.1097/00001574-199909000-00009
DO - 10.1097/00001574-199909000-00009
M3 - Article
C2 - 17023984
AN - SCOPUS:0032811472
SN - 0267-1379
VL - 15
SP - 423
EP - 429
JO - Current Opinion in Gastroenterology
JF - Current Opinion in Gastroenterology
IS - 5
ER -