Biliary tract physiology

Richard T. Prall, Nicholas F La Russo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Largely because of the recent development of new experimental models, cholangiocytes - the cells lining the bile ducts-are now recognized as important contributors to and modulators of bile formation. Recent work elucidating the mechanisms and regulation of fluid, solute and electrolyte transport indicates that the biliary epithelium influences bile formation through both autocrine and paracrine mechanisms. Novel roles for bile acids in cholangiocyte physiology have been proposed, and insight into the anatomic and functional differences of cholangiocytes along the biliary tree has been gained. Improved understanding of these concepts and the pathophysiologic response of the biliary tree to injury should provide new therapies for biliary diseases.

Original languageEnglish (US)
Pages (from-to)423-429
Number of pages7
JournalCurrent Opinion in Gastroenterology
Volume15
Issue number5
DOIs
StatePublished - 1999

Fingerprint

Biliary Tract
Bile
Bile Ducts
Bile Acids and Salts
Electrolytes
Theoretical Models
Epithelium
Wounds and Injuries
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Biliary tract physiology. / Prall, Richard T.; La Russo, Nicholas F.

In: Current Opinion in Gastroenterology, Vol. 15, No. 5, 1999, p. 423-429.

Research output: Contribution to journalArticle

Prall, Richard T. ; La Russo, Nicholas F. / Biliary tract physiology. In: Current Opinion in Gastroenterology. 1999 ; Vol. 15, No. 5. pp. 423-429.
@article{ef11c85885894fa2a4f9508fe800766d,
title = "Biliary tract physiology",
abstract = "Largely because of the recent development of new experimental models, cholangiocytes - the cells lining the bile ducts-are now recognized as important contributors to and modulators of bile formation. Recent work elucidating the mechanisms and regulation of fluid, solute and electrolyte transport indicates that the biliary epithelium influences bile formation through both autocrine and paracrine mechanisms. Novel roles for bile acids in cholangiocyte physiology have been proposed, and insight into the anatomic and functional differences of cholangiocytes along the biliary tree has been gained. Improved understanding of these concepts and the pathophysiologic response of the biliary tree to injury should provide new therapies for biliary diseases.",
author = "Prall, {Richard T.} and {La Russo}, {Nicholas F}",
year = "1999",
doi = "10.1097/00001574-199909000-00009",
language = "English (US)",
volume = "15",
pages = "423--429",
journal = "Current Opinion in Gastroenterology",
issn = "0267-1379",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Biliary tract physiology

AU - Prall, Richard T.

AU - La Russo, Nicholas F

PY - 1999

Y1 - 1999

N2 - Largely because of the recent development of new experimental models, cholangiocytes - the cells lining the bile ducts-are now recognized as important contributors to and modulators of bile formation. Recent work elucidating the mechanisms and regulation of fluid, solute and electrolyte transport indicates that the biliary epithelium influences bile formation through both autocrine and paracrine mechanisms. Novel roles for bile acids in cholangiocyte physiology have been proposed, and insight into the anatomic and functional differences of cholangiocytes along the biliary tree has been gained. Improved understanding of these concepts and the pathophysiologic response of the biliary tree to injury should provide new therapies for biliary diseases.

AB - Largely because of the recent development of new experimental models, cholangiocytes - the cells lining the bile ducts-are now recognized as important contributors to and modulators of bile formation. Recent work elucidating the mechanisms and regulation of fluid, solute and electrolyte transport indicates that the biliary epithelium influences bile formation through both autocrine and paracrine mechanisms. Novel roles for bile acids in cholangiocyte physiology have been proposed, and insight into the anatomic and functional differences of cholangiocytes along the biliary tree has been gained. Improved understanding of these concepts and the pathophysiologic response of the biliary tree to injury should provide new therapies for biliary diseases.

UR - http://www.scopus.com/inward/record.url?scp=0032811472&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032811472&partnerID=8YFLogxK

U2 - 10.1097/00001574-199909000-00009

DO - 10.1097/00001574-199909000-00009

M3 - Article

C2 - 17023984

AN - SCOPUS:0032811472

VL - 15

SP - 423

EP - 429

JO - Current Opinion in Gastroenterology

JF - Current Opinion in Gastroenterology

SN - 0267-1379

IS - 5

ER -