Benign metastasizing leiomyoma responsive to megestrol: Case report and review of the literature

G. K. Wentling, Bernd Uwe Sevin, X. J. Geiger, M. D. Bridges

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations

Abstract

Benign metastasizing leiomyoma (BML) is an unusual condition typically treated by surgical resection and hormonal therapy. A 37-year-old woman presented with dyspnea 6 years after uterine myomectomy. Com-puted tomographic scans showed pelvic and right-sided lung masses. Total abdominal hysterectomy and right salpingo-oophorectomy revealed only leiomyomas and benign ovarian cysts. Thoracotomy revealed multiple nodules consistent with leiomyomas. Estrogen and progesterone receptors on lung and uterine tissue were positive. A 21- × 18-mm residual area of neoplasm in the lung completely resolved 3 months after treatment with megestrol. The patient remains free of disease 3 years after lung resection. We present a rare case of BML in which the lung neoplasm responded to megestrol alone in the setting of intact ovarian function.

Original languageEnglish (US)
Pages (from-to)1213-1217
Number of pages5
JournalInternational Journal of Gynecological Cancer
Volume15
Issue number6
DOIs
StatePublished - Nov 1 2005

Keywords

  • Benign metastasizing leiomyoma
  • Lung neoplasm
  • Megestrol
  • Progesterone

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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