Benefits, risks, and safety of external beam radiation therapy for breast cancer

Lindsay C. Brown, Robert Mutter, Michele Y. Halyard

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Breast cancer is a common and complex disease often necessitating multimo­dality care. Breast cancer may be treated with surgical resection, radiotherapy (RT), and systemic therapy, including chemotherapy, hormonal therapy, and targeted therapies, or a combination thereof. In the past 50 years, RT has played an increasingly significant role in the treatment of breast cancer, resulting in improvements in locoregional control and sur­vival for women undergoing mastectomy who are at high risk of recurrence, and allowing for breast conservation in certain settings. Although radiation provides significant benefit to many women with breast cancer, it is also associated with risks of toxicity, including cardiac and pulmonary toxicity, lymphedema, and secondary malignancy. RT techniques have advanced and continue to evolve dramatically, offering increased precision and reproducibility of treatment delivery and flexibility of treatment schedule. This increased sophistication of RT offers promise of improved outcomes by maintaining or improving efficacy, reducing toxicity, and increasing patient access and convenience. A review of the role of radiation therapy in breast cancer, its associated toxicities and efforts in toxicity reduction is presented.

Original languageEnglish (US)
Pages (from-to)449-458
Number of pages10
JournalInternational Journal of Women's Health
Volume7
DOIs
StatePublished - Apr 24 2015

Fingerprint

Radiotherapy
Breast Neoplasms
Safety
Therapeutics
Lymphedema
Mastectomy
Appointments and Schedules
Breast
Radiation
Recurrence
Drug Therapy
Lung
Survival
Neoplasms

Keywords

  • Breast malignancy
  • Outcomes
  • Radiotherapy
  • Toxicity

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology
  • Maternity and Midwifery

Cite this

Benefits, risks, and safety of external beam radiation therapy for breast cancer. / Brown, Lindsay C.; Mutter, Robert; Halyard, Michele Y.

In: International Journal of Women's Health, Vol. 7, 24.04.2015, p. 449-458.

Research output: Contribution to journalArticle

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