Benefit of uridine triacetate (Vistogard) in rescuing severe 5-fluorouracil toxicity in patients with dihydropyrimidine dehydrogenase (DPYD) deficiency

Medicine & Life Sciences

• uridine triacetate 90%
• Dihydropyrimidine Dehydrogenase Deficiency 76%
• Fluorouracil 42%
• Dihydrouracil Dehydrogenase (NADP) 35%
• Thrombocytopenia 6%
• Reference Values 5%
• Orphan Drug Production 5%
• Uracil 4%
• Antidotes 4%
• Pancytopenia 4%
• Therapeutic Index 4%
• Fatal Outcome 3%
• Enzymes 3%
• Poisoning 3%
• Exanthema 3%
• Pancreatic Neoplasms 3%
• Autopsy 2%
• Poisons 2%
• Proteins 2%
• Mutation 1%
• Skin 1%
• Therapeutics 1%
• Neoplasms 1%

Chemical Compounds

• 5-Fluorouracil 52%
• Dose 12%
• Orphan Drug 6%
• Neurological Toxicity 6%
• Antidote 4%
• Uracil 3%
• Antineoplastic Agent 2%
• Mutation 2%
• Protein 2%
• Enzyme Activity 2%
• Toxic 2%