Abstract
Barrett's esophagus (BE) is the only established precursor lesion in the development of esophageal adenocarcinoma (EAC) and it increases the risk of cancer by 11-fold. It is regarded as a complication of gastroesophageal reflux disease. There is an ever-increasing body of knowledge on the pathogenesis, diagnosis, treatment, and surveillance of BE and its associated dysplasia. In this review, we summarize the latest advances in BE research and clinical practice in the past 2 years. It is critical to understand the molecular underpinnings of this disorder to comprehend the clinical outcomes of the disease. For clinical gastroenterologists, there is also continuous growth of endoscopic approaches which is daunting, and further improvements in the detection and treatment of BE and early EAC are anticipated. In the future, we may see the increased role of biomarkers, both molecular and imaging, in both diagnostic and therapeutic strategies for BE.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 322 |
| Number of pages | 1 |
| Journal | Current Gastroenterology Reports |
| Volume | 15 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2013 |
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ASJC Scopus subject areas
- Gastroenterology
Cite this
Barrett's esophagus in 2012 : updates in pathogenesis, treatment, and surveillance. / Chandra, Subhash; Gorospe, Emmanuel C.; Leggett, Cadman; Wang, Kenneth Ke Ning.
In: Current Gastroenterology Reports, Vol. 15, No. 5, 05.2013, p. 322.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Barrett's esophagus in 2012
T2 - updates in pathogenesis, treatment, and surveillance.
AU - Chandra, Subhash
AU - Gorospe, Emmanuel C.
AU - Leggett, Cadman
AU - Wang, Kenneth Ke Ning
PY - 2013/5
Y1 - 2013/5
N2 - Barrett's esophagus (BE) is the only established precursor lesion in the development of esophageal adenocarcinoma (EAC) and it increases the risk of cancer by 11-fold. It is regarded as a complication of gastroesophageal reflux disease. There is an ever-increasing body of knowledge on the pathogenesis, diagnosis, treatment, and surveillance of BE and its associated dysplasia. In this review, we summarize the latest advances in BE research and clinical practice in the past 2 years. It is critical to understand the molecular underpinnings of this disorder to comprehend the clinical outcomes of the disease. For clinical gastroenterologists, there is also continuous growth of endoscopic approaches which is daunting, and further improvements in the detection and treatment of BE and early EAC are anticipated. In the future, we may see the increased role of biomarkers, both molecular and imaging, in both diagnostic and therapeutic strategies for BE.
AB - Barrett's esophagus (BE) is the only established precursor lesion in the development of esophageal adenocarcinoma (EAC) and it increases the risk of cancer by 11-fold. It is regarded as a complication of gastroesophageal reflux disease. There is an ever-increasing body of knowledge on the pathogenesis, diagnosis, treatment, and surveillance of BE and its associated dysplasia. In this review, we summarize the latest advances in BE research and clinical practice in the past 2 years. It is critical to understand the molecular underpinnings of this disorder to comprehend the clinical outcomes of the disease. For clinical gastroenterologists, there is also continuous growth of endoscopic approaches which is daunting, and further improvements in the detection and treatment of BE and early EAC are anticipated. In the future, we may see the increased role of biomarkers, both molecular and imaging, in both diagnostic and therapeutic strategies for BE.
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UR - http://www.scopus.com/inward/citedby.url?scp=84884271739&partnerID=8YFLogxK
U2 - 10.1007/s11894-013-0322-8
DO - 10.1007/s11894-013-0322-8
M3 - Article
C2 - 23605564
AN - SCOPUS:84876196825
VL - 15
SP - 322
JO - Current Gastroenterology Reports
JF - Current Gastroenterology Reports
SN - 1522-8037
IS - 5
ER -