Bacterial growth on antibiotic-loaded acrylic cement. A prospective in vivo retrieval study

Richard W. Kendall, Clive P. Duncan, Christopher P. Beauchamp

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Twenty-three patients with intraoperative culture-proven periprosthetic infection of the hip or knee were enrolled in a prospective cement retrieval study. All were treated with a two-stage technique using antibiotic-loaded acrylic cement as an antibiotic depot. Staphylococcus epidermidis was the most commonly isolated organism (19 of 23 cases). Cement and tissue were examined at second-stage revision for the presence of viable organisms. In this series, no organisms were isolated from the surface of the cement, a 100% concordance with the tissue cultures. A subsequent failure rate of 4.4% (1 case) was seen in this series. Investigation suggests this may represent reinfection from a new strain of organism rather than failure of eradication of the original infection.

Original languageEnglish (US)
Pages (from-to)817-822
Number of pages6
JournalThe Journal of Arthroplasty
Volume10
Issue number6
DOIs
StatePublished - Dec 1995

Keywords

  • antibiotic-loaded cement
  • arthroplasty
  • infection
  • retrieval study

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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