B7-H1 determines accumulation and deletion of intrahepatic CD8+ T lymphocytes

Haidong Dong, Gefeng Zhu, Koji Tamada, Dallas B. Flies, Jan M.A. Van Deursen, Lieping Chen

Research output: Contribution to journalArticle

292 Scopus citations

Abstract

Upon systemic activation by antigens, CD8+, but not CD4 +, T cells selectively accumulate and undergo apoptosis in the liver, a mechanism associated with the induction of hepatic tolerance and chronic infection. The molecular basis for CD8+ T cell preference in this process is unknown. We prepared B7-H1-deficient mice by gene targeting and found spontaneous accumulation of CD8+ T cells in the liver while CD4+ T cell levels remained normal. Moreover, antigen-driven CD8 + T cells proliferated normally while apoptotic levels during the contraction phase was selectively impaired in the liver, leading to accelerated hepatocyte damage in experimental autoimmune hepatitis. Therefore, B7-H1 is a key protein selectively regulating the accumulation and deletion of intrahepatic CD8+ T cells and may also contribute to inflammation, autoimmune diseases, and tolerance in the liver.

Original languageEnglish (US)
Pages (from-to)327-336
Number of pages10
JournalImmunity
Volume20
Issue number3
DOIs
StatePublished - Mar 1 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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