TY - JOUR
T1 - Autonomic complaints in patients with restless legs syndrome
AU - Shneyder, Natalya
AU - Adler, Charles H.
AU - Hentz, Joseph G.
AU - Shill, Holly
AU - Caviness, John N.
AU - Sabbagh, Marwan N.
AU - Beach, Thomas G.
AU - Driver-Dunckley, Erika
N1 - Funding Information:
This study was funded by the Arizona Biomedical Research Commission (contracts 4001, 05-901, 0011, and 1001), the Michael J. Fox Foundation for Parkinson’s Research (Prescott Family Initiative), the Arizona Department of Health Services (contract 211002), the National Institute on Aging (P30 AG19610), the Mayo Clinic Foundation for Medical Education and Research, and the Sun Health Foundation.
PY - 2013/12
Y1 - 2013/12
N2 - Background: Data regarding autonomic function in restless legs syndrome (RLS) are limited to heart rate and blood pressure changes in cases with periodic limb movements (PLMS). Methods: We compared autonomic symptoms of 49 subjects with RLS vs 291 control subjects using the Scales for Outcome in Parkinson disease-Autonomic (SCOPA-AUT) questionnaire, consisting of 23 items in six domains scored from 0 to 3. The total score and domain scores were transformed to 0-100 points. Subjects with neurodegenerative disorders (i.e., dementia, Parkinsonism) were excluded. Results: The RLS group was younger (mean. ±. standard deviation, 77.9. ±. 8.0 vs 80.5. ±. 7.9. years; P=.03) and included more women (84% vs 69%; P=.04). The mean SCOPA-AUT total score was higher in the RLS group compared with the control group (20. ±. 11 vs 16. ±. 9; P=.005). Additionally the RLS group had abnormalities in gastrointestinal, cardiovascular, and pupillomotor domains. When comparing the percentage of subjects with any complaint on individual questions (score of ≥1), the RLS group had a greater number of subjects with sialorrhea, constipation, early abdominal fullness, lightheadedness when standing, and heat intolerance. Conclusions: Autonomic complaints, especially gastrointestinal, cardiovascular, and oversensitivity to light, were significantly increased in subjects with RLS. Causes for autonomic dysfunction in RLS require further investigation.
AB - Background: Data regarding autonomic function in restless legs syndrome (RLS) are limited to heart rate and blood pressure changes in cases with periodic limb movements (PLMS). Methods: We compared autonomic symptoms of 49 subjects with RLS vs 291 control subjects using the Scales for Outcome in Parkinson disease-Autonomic (SCOPA-AUT) questionnaire, consisting of 23 items in six domains scored from 0 to 3. The total score and domain scores were transformed to 0-100 points. Subjects with neurodegenerative disorders (i.e., dementia, Parkinsonism) were excluded. Results: The RLS group was younger (mean. ±. standard deviation, 77.9. ±. 8.0 vs 80.5. ±. 7.9. years; P=.03) and included more women (84% vs 69%; P=.04). The mean SCOPA-AUT total score was higher in the RLS group compared with the control group (20. ±. 11 vs 16. ±. 9; P=.005). Additionally the RLS group had abnormalities in gastrointestinal, cardiovascular, and pupillomotor domains. When comparing the percentage of subjects with any complaint on individual questions (score of ≥1), the RLS group had a greater number of subjects with sialorrhea, constipation, early abdominal fullness, lightheadedness when standing, and heat intolerance. Conclusions: Autonomic complaints, especially gastrointestinal, cardiovascular, and oversensitivity to light, were significantly increased in subjects with RLS. Causes for autonomic dysfunction in RLS require further investigation.
KW - Autonomic complaints
KW - Autonomic dysfunction
KW - Gastrointestinal symptoms
KW - Periodic limb movements
KW - Restless legs syndrome
KW - SCOPA
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U2 - 10.1016/j.sleep.2013.08.781
DO - 10.1016/j.sleep.2013.08.781
M3 - Article
C2 - 24152795
AN - SCOPUS:84888137649
SN - 1389-9457
VL - 14
SP - 1413
EP - 1416
JO - Sleep Medicine
JF - Sleep Medicine
IS - 12
ER -