Autonomic complaints in patients with restless legs syndrome

Natalya Shneyder, Charles Howard Adler, Joseph G. Hentz, Holly Shill, John Nathaniel Caviness, Marwan N. Sabbagh, Thomas G. Beach, Erika M Driver-Dunckley

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Data regarding autonomic function in restless legs syndrome (RLS) are limited to heart rate and blood pressure changes in cases with periodic limb movements (PLMS). Methods: We compared autonomic symptoms of 49 subjects with RLS vs 291 control subjects using the Scales for Outcome in Parkinson disease-Autonomic (SCOPA-AUT) questionnaire, consisting of 23 items in six domains scored from 0 to 3. The total score and domain scores were transformed to 0-100 points. Subjects with neurodegenerative disorders (i.e., dementia, Parkinsonism) were excluded. Results: The RLS group was younger (mean. ±. standard deviation, 77.9. ±. 8.0 vs 80.5. ±. 7.9. years; P=.03) and included more women (84% vs 69%; P=.04). The mean SCOPA-AUT total score was higher in the RLS group compared with the control group (20. ±. 11 vs 16. ±. 9; P=.005). Additionally the RLS group had abnormalities in gastrointestinal, cardiovascular, and pupillomotor domains. When comparing the percentage of subjects with any complaint on individual questions (score of ≥1), the RLS group had a greater number of subjects with sialorrhea, constipation, early abdominal fullness, lightheadedness when standing, and heat intolerance. Conclusions: Autonomic complaints, especially gastrointestinal, cardiovascular, and oversensitivity to light, were significantly increased in subjects with RLS. Causes for autonomic dysfunction in RLS require further investigation.

Original languageEnglish (US)
Pages (from-to)1413-1416
Number of pages4
JournalSleep Medicine
Volume14
Issue number12
DOIs
StatePublished - Dec 2013

Fingerprint

Restless Legs Syndrome
Parkinson Disease
Sialorrhea
Parkinsonian Disorders
Dizziness
Constipation
Neurodegenerative Diseases
Dementia
Extremities
Hot Temperature
Heart Rate
Blood Pressure
Light
Control Groups

Keywords

  • Autonomic complaints
  • Autonomic dysfunction
  • Gastrointestinal symptoms
  • Periodic limb movements
  • Restless legs syndrome
  • SCOPA

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Autonomic complaints in patients with restless legs syndrome. / Shneyder, Natalya; Adler, Charles Howard; Hentz, Joseph G.; Shill, Holly; Caviness, John Nathaniel; Sabbagh, Marwan N.; Beach, Thomas G.; Driver-Dunckley, Erika M.

In: Sleep Medicine, Vol. 14, No. 12, 12.2013, p. 1413-1416.

Research output: Contribution to journalArticle

Shneyder, Natalya ; Adler, Charles Howard ; Hentz, Joseph G. ; Shill, Holly ; Caviness, John Nathaniel ; Sabbagh, Marwan N. ; Beach, Thomas G. ; Driver-Dunckley, Erika M. / Autonomic complaints in patients with restless legs syndrome. In: Sleep Medicine. 2013 ; Vol. 14, No. 12. pp. 1413-1416.
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