Autoimmune thyroiditis

A model uniquely suited to probe regulatory T cell function

Yi chi M Kong, Gerald P. Morris, Nicholas K. Brown, Yan Yan, Jeffrey C. Flynn, Chella S. David

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Murine experimental autoimmune thyroiditis (EAT) is a model for Hashimoto's thyroiditis that has served as a prototype of T cell-mediated autoimmunity for more than three decades. Key roles for MHC restriction and autoantigen influence on susceptibility to autoimmunity have been demonstrated in EAT. Moreover, it has served a unique role in investigations of self tolerance. In the early 1980s, self tolerance and resistance to EAT induction could be enhanced by increasing circulating levels of the autoantigen, thyroglobulin (Tg), by exogenous addition as well as endogenous release. This observation, directly linking circulating self antigen to self tolerance, led to subsequent investigations of the role of regulatory T cells (Tregs) in self tolerance. These studies revealed that protection against autoimmunity, in both naive and tolerized mice, was mediated by thymically-derived CD4+CD25+Foxp3+ Tregs. Moreover, these naturally-existing Tregs required proper costimulation, in context with autoantigen presentation, to maintain and enhance self tolerance. In particular was the selected use of MHC- and heterologous Tg-restricted models from both conventional and transgenic mice. These models helped to elucidate the complex interplay between autoantigen presentation and MHC class II-mediated T cell selection in the development of Treg and autoreactive T cell repertoires determining susceptibility to autoimmunity. Here we describe these investigations in further detail, providing a context for how EAT has helped shape our understanding of self tolerance and autoimmunity.

Original languageEnglish (US)
Pages (from-to)239-246
Number of pages8
JournalJournal of Autoimmunity
Volume33
Issue number3-4
DOIs
StatePublished - Nov 2009

Fingerprint

Self Tolerance
Autoimmune Thyroiditis
Regulatory T-Lymphocytes
Autoimmunity
Autoantigens
Thyroglobulin
T-Lymphocytes
Hashimoto Disease
Transgenic Mice

Keywords

  • Autoimmune thyroiditis
  • Circulatory thyroglobulin
  • Enhancing self tolerance
  • MHC influence and autoimmunity
  • Regulatory T cells
  • Regulatory T cells and autoimmunity
  • Tolerance augmentation

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Kong, Y. C. M., Morris, G. P., Brown, N. K., Yan, Y., Flynn, J. C., & David, C. S. (2009). Autoimmune thyroiditis: A model uniquely suited to probe regulatory T cell function. Journal of Autoimmunity, 33(3-4), 239-246. https://doi.org/10.1016/j.jaut.2009.09.004

Autoimmune thyroiditis : A model uniquely suited to probe regulatory T cell function. / Kong, Yi chi M; Morris, Gerald P.; Brown, Nicholas K.; Yan, Yan; Flynn, Jeffrey C.; David, Chella S.

In: Journal of Autoimmunity, Vol. 33, No. 3-4, 11.2009, p. 239-246.

Research output: Contribution to journalArticle

Kong, YCM, Morris, GP, Brown, NK, Yan, Y, Flynn, JC & David, CS 2009, 'Autoimmune thyroiditis: A model uniquely suited to probe regulatory T cell function', Journal of Autoimmunity, vol. 33, no. 3-4, pp. 239-246. https://doi.org/10.1016/j.jaut.2009.09.004
Kong, Yi chi M ; Morris, Gerald P. ; Brown, Nicholas K. ; Yan, Yan ; Flynn, Jeffrey C. ; David, Chella S. / Autoimmune thyroiditis : A model uniquely suited to probe regulatory T cell function. In: Journal of Autoimmunity. 2009 ; Vol. 33, No. 3-4. pp. 239-246.
@article{61ba650379f0466da85179c10a87c38c,
title = "Autoimmune thyroiditis: A model uniquely suited to probe regulatory T cell function",
abstract = "Murine experimental autoimmune thyroiditis (EAT) is a model for Hashimoto's thyroiditis that has served as a prototype of T cell-mediated autoimmunity for more than three decades. Key roles for MHC restriction and autoantigen influence on susceptibility to autoimmunity have been demonstrated in EAT. Moreover, it has served a unique role in investigations of self tolerance. In the early 1980s, self tolerance and resistance to EAT induction could be enhanced by increasing circulating levels of the autoantigen, thyroglobulin (Tg), by exogenous addition as well as endogenous release. This observation, directly linking circulating self antigen to self tolerance, led to subsequent investigations of the role of regulatory T cells (Tregs) in self tolerance. These studies revealed that protection against autoimmunity, in both naive and tolerized mice, was mediated by thymically-derived CD4+CD25+Foxp3+ Tregs. Moreover, these naturally-existing Tregs required proper costimulation, in context with autoantigen presentation, to maintain and enhance self tolerance. In particular was the selected use of MHC- and heterologous Tg-restricted models from both conventional and transgenic mice. These models helped to elucidate the complex interplay between autoantigen presentation and MHC class II-mediated T cell selection in the development of Treg and autoreactive T cell repertoires determining susceptibility to autoimmunity. Here we describe these investigations in further detail, providing a context for how EAT has helped shape our understanding of self tolerance and autoimmunity.",
keywords = "Autoimmune thyroiditis, Circulatory thyroglobulin, Enhancing self tolerance, MHC influence and autoimmunity, Regulatory T cells, Regulatory T cells and autoimmunity, Tolerance augmentation",
author = "Kong, {Yi chi M} and Morris, {Gerald P.} and Brown, {Nicholas K.} and Yan Yan and Flynn, {Jeffrey C.} and David, {Chella S.}",
year = "2009",
month = "11",
doi = "10.1016/j.jaut.2009.09.004",
language = "English (US)",
volume = "33",
pages = "239--246",
journal = "Journal of Autoimmunity",
issn = "0896-8411",
publisher = "Academic Press Inc.",
number = "3-4",

}

TY - JOUR

T1 - Autoimmune thyroiditis

T2 - A model uniquely suited to probe regulatory T cell function

AU - Kong, Yi chi M

AU - Morris, Gerald P.

AU - Brown, Nicholas K.

AU - Yan, Yan

AU - Flynn, Jeffrey C.

AU - David, Chella S.

PY - 2009/11

Y1 - 2009/11

N2 - Murine experimental autoimmune thyroiditis (EAT) is a model for Hashimoto's thyroiditis that has served as a prototype of T cell-mediated autoimmunity for more than three decades. Key roles for MHC restriction and autoantigen influence on susceptibility to autoimmunity have been demonstrated in EAT. Moreover, it has served a unique role in investigations of self tolerance. In the early 1980s, self tolerance and resistance to EAT induction could be enhanced by increasing circulating levels of the autoantigen, thyroglobulin (Tg), by exogenous addition as well as endogenous release. This observation, directly linking circulating self antigen to self tolerance, led to subsequent investigations of the role of regulatory T cells (Tregs) in self tolerance. These studies revealed that protection against autoimmunity, in both naive and tolerized mice, was mediated by thymically-derived CD4+CD25+Foxp3+ Tregs. Moreover, these naturally-existing Tregs required proper costimulation, in context with autoantigen presentation, to maintain and enhance self tolerance. In particular was the selected use of MHC- and heterologous Tg-restricted models from both conventional and transgenic mice. These models helped to elucidate the complex interplay between autoantigen presentation and MHC class II-mediated T cell selection in the development of Treg and autoreactive T cell repertoires determining susceptibility to autoimmunity. Here we describe these investigations in further detail, providing a context for how EAT has helped shape our understanding of self tolerance and autoimmunity.

AB - Murine experimental autoimmune thyroiditis (EAT) is a model for Hashimoto's thyroiditis that has served as a prototype of T cell-mediated autoimmunity for more than three decades. Key roles for MHC restriction and autoantigen influence on susceptibility to autoimmunity have been demonstrated in EAT. Moreover, it has served a unique role in investigations of self tolerance. In the early 1980s, self tolerance and resistance to EAT induction could be enhanced by increasing circulating levels of the autoantigen, thyroglobulin (Tg), by exogenous addition as well as endogenous release. This observation, directly linking circulating self antigen to self tolerance, led to subsequent investigations of the role of regulatory T cells (Tregs) in self tolerance. These studies revealed that protection against autoimmunity, in both naive and tolerized mice, was mediated by thymically-derived CD4+CD25+Foxp3+ Tregs. Moreover, these naturally-existing Tregs required proper costimulation, in context with autoantigen presentation, to maintain and enhance self tolerance. In particular was the selected use of MHC- and heterologous Tg-restricted models from both conventional and transgenic mice. These models helped to elucidate the complex interplay between autoantigen presentation and MHC class II-mediated T cell selection in the development of Treg and autoreactive T cell repertoires determining susceptibility to autoimmunity. Here we describe these investigations in further detail, providing a context for how EAT has helped shape our understanding of self tolerance and autoimmunity.

KW - Autoimmune thyroiditis

KW - Circulatory thyroglobulin

KW - Enhancing self tolerance

KW - MHC influence and autoimmunity

KW - Regulatory T cells

KW - Regulatory T cells and autoimmunity

KW - Tolerance augmentation

UR - http://www.scopus.com/inward/record.url?scp=71649114308&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=71649114308&partnerID=8YFLogxK

U2 - 10.1016/j.jaut.2009.09.004

DO - 10.1016/j.jaut.2009.09.004

M3 - Article

VL - 33

SP - 239

EP - 246

JO - Journal of Autoimmunity

JF - Journal of Autoimmunity

SN - 0896-8411

IS - 3-4

ER -