Autoantibody studies in juvenile rheumatoid arthritis

James M. Lawrence, Terry L. Moore, Thomas Osborn, Gideon Nesher, Katherine L. Madson, Margaret B. Kinsella

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Early studies showed few immunologic abnormalities in juvenile rheumatoid arthritis (JRA) patients. There were no specific laboratory markers useful for diagnosis and assessment of the course of disease in JRA. Previous work showed an association of antinuclear antibodies (ANA) with early-onset pauciarticular disease and iridocyclitis. Similarly, the presence of 19S immunoglobulin (Ig) M rheumatoid factors (RF) was associated with late-onset polyarticular disease in girls. More recent studies have detected many unique autoantibodies. Newer assays show 19S IgM RF in up to 35% of JRA patients, although still mainly in girls with late-onset polyarticular disease. Hidden 19S IgM RF can be shown in up to 75% of JRA patients using different procedures, primarily in those with active polyarticular- or pauciarticular-onset disease. Immune complexes have been detected in JRA patients by means of different techniques; their presence usually correlates with active disease. Studies on a specific ANA in JRA have shown no common extractable nuclear antigen, but antihistone antibodies have been found in up to 75% of cases, again mainly in those with pauciarticular onset and iritis. Finally, a variety of unusual immunologic proteins have also been detected, including anti-ocular, anti-cellular, anti-cardiolipin, anti-perinuclear factor, and anti-collagen antibodies. This review evaluates the significance of these antibodies that can now be found in JRA.

Original languageEnglish (US)
Pages (from-to)265-274
Number of pages10
JournalSeminars in Arthritis and Rheumatism
Volume22
Issue number4
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

Fingerprint

Juvenile Arthritis
Autoantibodies
Rheumatoid Factor
Immunoglobulin M
Antinuclear Antibodies
Iritis
Iridocyclitis
Nuclear Antigens
Cardiolipins
Antibodies
Antigen-Antibody Complex
Anti-Idiotypic Antibodies
Collagen
Biomarkers

Keywords

  • antinuclear antibody
  • autoantibodies
  • Juvenile rheumatoid arthritis
  • rheumatoid factors

ASJC Scopus subject areas

  • Rheumatology
  • Anesthesiology and Pain Medicine

Cite this

Lawrence, J. M., Moore, T. L., Osborn, T., Nesher, G., Madson, K. L., & Kinsella, M. B. (1993). Autoantibody studies in juvenile rheumatoid arthritis. Seminars in Arthritis and Rheumatism, 22(4), 265-274. https://doi.org/10.1016/0049-0172(93)80074-P

Autoantibody studies in juvenile rheumatoid arthritis. / Lawrence, James M.; Moore, Terry L.; Osborn, Thomas; Nesher, Gideon; Madson, Katherine L.; Kinsella, Margaret B.

In: Seminars in Arthritis and Rheumatism, Vol. 22, No. 4, 01.01.1993, p. 265-274.

Research output: Contribution to journalArticle

Lawrence, JM, Moore, TL, Osborn, T, Nesher, G, Madson, KL & Kinsella, MB 1993, 'Autoantibody studies in juvenile rheumatoid arthritis', Seminars in Arthritis and Rheumatism, vol. 22, no. 4, pp. 265-274. https://doi.org/10.1016/0049-0172(93)80074-P
Lawrence, James M. ; Moore, Terry L. ; Osborn, Thomas ; Nesher, Gideon ; Madson, Katherine L. ; Kinsella, Margaret B. / Autoantibody studies in juvenile rheumatoid arthritis. In: Seminars in Arthritis and Rheumatism. 1993 ; Vol. 22, No. 4. pp. 265-274.
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