TY - JOUR
T1 - Autoantibody studies in juvenile rheumatoid arthritis
AU - Lawrence, James M.
AU - Moore, Terry L.
AU - Osborn, Thomas G.
AU - Nesher, Gideon
AU - Madson, Katherine L.
AU - Kinsella, Margaret B.
N1 - Funding Information:
Supported hi part by fellowship grants from the Eastern Missouri chapter of the Lupus Foundation of America, hlc (J.M.L.) and the Eastern Missouri chapter of the Arthritis Foundation (K. L.M.), by research grants from the Employees Charity Sen,ices of McDonnell-Douglas Corporation of St Louis and the Eastern Missouri chapter of the Arthritis Foundation, and by a Regional Arthritis Center grant from the state of Missouri.
PY - 1993/2
Y1 - 1993/2
N2 - Early studies showed few immunologic abnormalities in juvenile rheumatoid arthritis (JRA) patients. There were no specific laboratory markers useful for diagnosis and assessment of the course of disease in JRA. Previous work showed an association of antinuclear antibodies (ANA) with early-onset pauciarticular disease and iridocyclitis. Similarly, the presence of 19S immunoglobulin (Ig) M rheumatoid factors (RF) was associated with late-onset polyarticular disease in girls. More recent studies have detected many unique autoantibodies. Newer assays show 19S IgM RF in up to 35% of JRA patients, although still mainly in girls with late-onset polyarticular disease. Hidden 19S IgM RF can be shown in up to 75% of JRA patients using different procedures, primarily in those with active polyarticular- or pauciarticular-onset disease. Immune complexes have been detected in JRA patients by means of different techniques; their presence usually correlates with active disease. Studies on a specific ANA in JRA have shown no common extractable nuclear antigen, but antihistone antibodies have been found in up to 75% of cases, again mainly in those with pauciarticular onset and iritis. Finally, a variety of unusual immunologic proteins have also been detected, including anti-ocular, anti-cellular, anti-cardiolipin, anti-perinuclear factor, and anti-collagen antibodies. This review evaluates the significance of these antibodies that can now be found in JRA.
AB - Early studies showed few immunologic abnormalities in juvenile rheumatoid arthritis (JRA) patients. There were no specific laboratory markers useful for diagnosis and assessment of the course of disease in JRA. Previous work showed an association of antinuclear antibodies (ANA) with early-onset pauciarticular disease and iridocyclitis. Similarly, the presence of 19S immunoglobulin (Ig) M rheumatoid factors (RF) was associated with late-onset polyarticular disease in girls. More recent studies have detected many unique autoantibodies. Newer assays show 19S IgM RF in up to 35% of JRA patients, although still mainly in girls with late-onset polyarticular disease. Hidden 19S IgM RF can be shown in up to 75% of JRA patients using different procedures, primarily in those with active polyarticular- or pauciarticular-onset disease. Immune complexes have been detected in JRA patients by means of different techniques; their presence usually correlates with active disease. Studies on a specific ANA in JRA have shown no common extractable nuclear antigen, but antihistone antibodies have been found in up to 75% of cases, again mainly in those with pauciarticular onset and iritis. Finally, a variety of unusual immunologic proteins have also been detected, including anti-ocular, anti-cellular, anti-cardiolipin, anti-perinuclear factor, and anti-collagen antibodies. This review evaluates the significance of these antibodies that can now be found in JRA.
KW - Juvenile rheumatoid arthritis
KW - antinuclear antibody
KW - autoantibodies
KW - rheumatoid factors
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U2 - 10.1016/0049-0172(93)80074-P
DO - 10.1016/0049-0172(93)80074-P
M3 - Article
C2 - 8484133
AN - SCOPUS:0027475570
SN - 0049-0172
VL - 22
SP - 265
EP - 274
JO - Seminars in Arthritis and Rheumatism
JF - Seminars in Arthritis and Rheumatism
IS - 4
ER -