Abstract
To the Editor: Drachman et al. (Sept. 23 issue)1 suggest that the functional activities of autoantibodies to acetylcholine receptors correlate well with the clinical severity of myasthenia gravis. This is an issue we have addressed for a number of years, reaching the opposite conclusion.2,3 It is well accepted that the clinical state does not correlate well with the antibody titer4,5 and that the degradation ratio correlates directly with the antibody titer.3,6 The logical deduction from these two premises is that the degradation ratio does not correlate with the clinical state. This difference in conclusion can be explained by an examination.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 402-403 |
| Number of pages | 2 |
| Journal | New England Journal of Medicine |
| Volume | 308 |
| Issue number | 7 |
| DOIs | |
| State | Published - Feb 17 1983 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Autoantibodies to Acetylcholine Receptors in Myasthenia Gravis. / Elias, Stanton B.; Appel, Stanley H.; Lennon, Vanda A; Jones, Gregory; Howard, Frank; Elveback, Lila; Drachman, Daniel B.; Adams, Robert N.; Josifek, Lorraine F.; Self, Steven G.
In: New England Journal of Medicine, Vol. 308, No. 7, 17.02.1983, p. 402-403.Research output: Contribution to journal › Letter
}
TY - JOUR
T1 - Autoantibodies to Acetylcholine Receptors in Myasthenia Gravis
AU - Elias, Stanton B.
AU - Appel, Stanley H.
AU - Lennon, Vanda A
AU - Jones, Gregory
AU - Howard, Frank
AU - Elveback, Lila
AU - Drachman, Daniel B.
AU - Adams, Robert N.
AU - Josifek, Lorraine F.
AU - Self, Steven G.
PY - 1983/2/17
Y1 - 1983/2/17
N2 - To the Editor: Drachman et al. (Sept. 23 issue)1 suggest that the functional activities of autoantibodies to acetylcholine receptors correlate well with the clinical severity of myasthenia gravis. This is an issue we have addressed for a number of years, reaching the opposite conclusion.2,3 It is well accepted that the clinical state does not correlate well with the antibody titer4,5 and that the degradation ratio correlates directly with the antibody titer.3,6 The logical deduction from these two premises is that the degradation ratio does not correlate with the clinical state. This difference in conclusion can be explained by an examination.
AB - To the Editor: Drachman et al. (Sept. 23 issue)1 suggest that the functional activities of autoantibodies to acetylcholine receptors correlate well with the clinical severity of myasthenia gravis. This is an issue we have addressed for a number of years, reaching the opposite conclusion.2,3 It is well accepted that the clinical state does not correlate well with the antibody titer4,5 and that the degradation ratio correlates directly with the antibody titer.3,6 The logical deduction from these two premises is that the degradation ratio does not correlate with the clinical state. This difference in conclusion can be explained by an examination.
UR - http://www.scopus.com/inward/record.url?scp=0021106642&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021106642&partnerID=8YFLogxK
U2 - 10.1056/NEJM198302173080718
DO - 10.1056/NEJM198302173080718
M3 - Letter
C2 - 6823248
AN - SCOPUS:0021106642
VL - 308
SP - 402
EP - 403
JO - New England Journal of Medicine
JF - New England Journal of Medicine
SN - 1533-4406
IS - 7
ER -