Autoantibodies to Acetylcholine Receptors in Myasthenia Gravis

Stanton B. Elias; Stanley H. Appel; Vanda A. Lennon; Gregory Jones; Frank Howard; Lila Elveback; Daniel B. Drachman; Robert N. Adams; Lorraine F. Josifek; Steven G. Self

doi:10.1056/NEJM198302173080718

Autoantibodies to Acetylcholine Receptors in Myasthenia Gravis

Stanton B. Elias, Stanley H. Appel, Vanda A. Lennon, Gregory Jones, Frank Howard, Lila Elveback, Daniel B. Drachman, Robert N. Adams, Lorraine F. Josifek, Steven G. Self

Laboratory Medicine and Pathology

Research output: Contribution to journal › Letter › peer-review

30 Scopus citations

Abstract

To the Editor: Drachman et al. (Sept. 23 issue)¹ suggest that the functional activities of autoantibodies to acetylcholine receptors correlate well with the clinical severity of myasthenia gravis. This is an issue we have addressed for a number of years, reaching the opposite conclusion.^2,3 It is well accepted that the clinical state does not correlate well with the antibody titer^4,5 and that the degradation ratio correlates directly with the antibody titer.^3,6 The logical deduction from these two premises is that the degradation ratio does not correlate with the clinical state. This difference in conclusion can be explained by an examination.

Original language	English (US)
Pages (from-to)	402-403
Number of pages	2
Journal	New England Journal of Medicine
Volume	308
Issue number	7
DOIs	https://doi.org/10.1056/NEJM198302173080718
State	Published - Feb 17 1983

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Medicine(all)

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Autoantibodies to Acetylcholine Receptors in Myasthenia Gravis. / Elias, Stanton B.; Appel, Stanley H.; Lennon, Vanda A.; Jones, Gregory; Howard, Frank; Elveback, Lila; Drachman, Daniel B.; Adams, Robert N.; Josifek, Lorraine F.; Self, Steven G.

In: New England Journal of Medicine, Vol. 308, No. 7, 17.02.1983, p. 402-403.

Research output: Contribution to journal › Letter › peer-review

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abstract = "To the Editor: Drachman et al. (Sept. 23 issue)1 suggest that the functional activities of autoantibodies to acetylcholine receptors correlate well with the clinical severity of myasthenia gravis. This is an issue we have addressed for a number of years, reaching the opposite conclusion.2,3 It is well accepted that the clinical state does not correlate well with the antibody titer4,5 and that the degradation ratio correlates directly with the antibody titer.3,6 The logical deduction from these two premises is that the degradation ratio does not correlate with the clinical state. This difference in conclusion can be explained by an examination.",

author = "Elias, {Stanton B.} and Appel, {Stanley H.} and Lennon, {Vanda A.} and Gregory Jones and Frank Howard and Lila Elveback and Drachman, {Daniel B.} and Adams, {Robert N.} and Josifek, {Lorraine F.} and Self, {Steven G.}",

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AU - Elias, Stanton B.

AU - Appel, Stanley H.

AU - Lennon, Vanda A.

AU - Jones, Gregory

AU - Howard, Frank

AU - Elveback, Lila

AU - Drachman, Daniel B.

AU - Adams, Robert N.

AU - Josifek, Lorraine F.

AU - Self, Steven G.

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N2 - To the Editor: Drachman et al. (Sept. 23 issue)1 suggest that the functional activities of autoantibodies to acetylcholine receptors correlate well with the clinical severity of myasthenia gravis. This is an issue we have addressed for a number of years, reaching the opposite conclusion.2,3 It is well accepted that the clinical state does not correlate well with the antibody titer4,5 and that the degradation ratio correlates directly with the antibody titer.3,6 The logical deduction from these two premises is that the degradation ratio does not correlate with the clinical state. This difference in conclusion can be explained by an examination.

AB - To the Editor: Drachman et al. (Sept. 23 issue)1 suggest that the functional activities of autoantibodies to acetylcholine receptors correlate well with the clinical severity of myasthenia gravis. This is an issue we have addressed for a number of years, reaching the opposite conclusion.2,3 It is well accepted that the clinical state does not correlate well with the antibody titer4,5 and that the degradation ratio correlates directly with the antibody titer.3,6 The logical deduction from these two premises is that the degradation ratio does not correlate with the clinical state. This difference in conclusion can be explained by an examination.

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Autoantibodies to Acetylcholine Receptors in Myasthenia Gravis

Abstract

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