Attenuated pulsatile release of prolactin in men with insulin-dependent diabetes mellitus

Ali Iranmanesh, Johannes D Veldhuis, Elisabeth C. Carlsen, Veronica A. Vaccaro, Robert A. Booth, German Lizarralde, Christopher M. Asplin, William S. Evans

Research output: Contribution to journalArticle

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Abstract

Pulsatile and circadian patterns of PRL release were studied in 11 insulin-dependent diabetic men by sampling blood every 10 min for 24 h and comparing the results to those obtained in 12 normal nondiabetic men. The diabetic men had a mean (±SE) 24-h serum PRL concentration of 5.5 ± 0.42 μg/ L, which was significantly lower than that in the nondiabetic men (9.3 ± 0.86; P = 0.0008). Quantitative Cluster analysis of pulsatile PRL time series revealed a normal pulse frequency, but decreased maximal peak amplitude (6.6 ± 0.5 vs. 11.8 ± 1.1 μg/ L; P = 0.0009), peak increment (2.6 ± 0.24 vs. 4.0 ± 0.3 μg/L; P = 0.009), peak area (126 ± 15 vs. 192 ± 19 μg/L·min; P = 0.03), and interpulse valley mean concentration (4.8 ± 0.4 vs. 8.6 ± 1.2 μg/L; P = 0.0007). PRL pulse incremental amplitude correlated significantly (r2 = 0.577; P = 0.007) and negatively with duration of disease. Fourier analysis disclosed a normal circadian rhythm of PRL release in diabetic men, with a mean circadian amplitude of 1.5 μg/L ± 0.31, which peaked at 0201 h ± 89 min (±SE). In summary, we have demonstrated significantly reduced mean 24-h serum PRL concentrations in men with poorly controlled insulin-dependent diabetes mellitus. The concomitant suppression of spontaneous PRL pulse amplitude, peak increment, and interpulse valley mean concentrations in the presence of normal pulse frequency is consistent with a reduced mass of PRL secreted per burst and/or accelerated metabolic clearance of PRL in men with type I diabetes mellitus. (J Clin Endocrinol Metab 71: 73-78, 1990).

Original languageEnglish (US)
Pages (from-to)73-78
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume71
Issue number1
StatePublished - Jul 1990
Externally publishedYes

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Medical problems
Type 1 Diabetes Mellitus
Prolactin
Insulin
Fourier analysis
Cluster analysis
Time series
Blood
Sampling
Fourier Analysis
Circadian Rhythm
Serum
Cluster Analysis

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Iranmanesh, A., Veldhuis, J. D., Carlsen, E. C., Vaccaro, V. A., Booth, R. A., Lizarralde, G., ... Evans, W. S. (1990). Attenuated pulsatile release of prolactin in men with insulin-dependent diabetes mellitus. Journal of Clinical Endocrinology and Metabolism, 71(1), 73-78.

Attenuated pulsatile release of prolactin in men with insulin-dependent diabetes mellitus. / Iranmanesh, Ali; Veldhuis, Johannes D; Carlsen, Elisabeth C.; Vaccaro, Veronica A.; Booth, Robert A.; Lizarralde, German; Asplin, Christopher M.; Evans, William S.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 71, No. 1, 07.1990, p. 73-78.

Research output: Contribution to journalArticle

Iranmanesh, A, Veldhuis, JD, Carlsen, EC, Vaccaro, VA, Booth, RA, Lizarralde, G, Asplin, CM & Evans, WS 1990, 'Attenuated pulsatile release of prolactin in men with insulin-dependent diabetes mellitus', Journal of Clinical Endocrinology and Metabolism, vol. 71, no. 1, pp. 73-78.
Iranmanesh A, Veldhuis JD, Carlsen EC, Vaccaro VA, Booth RA, Lizarralde G et al. Attenuated pulsatile release of prolactin in men with insulin-dependent diabetes mellitus. Journal of Clinical Endocrinology and Metabolism. 1990 Jul;71(1):73-78.
Iranmanesh, Ali ; Veldhuis, Johannes D ; Carlsen, Elisabeth C. ; Vaccaro, Veronica A. ; Booth, Robert A. ; Lizarralde, German ; Asplin, Christopher M. ; Evans, William S. / Attenuated pulsatile release of prolactin in men with insulin-dependent diabetes mellitus. In: Journal of Clinical Endocrinology and Metabolism. 1990 ; Vol. 71, No. 1. pp. 73-78.
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abstract = "Pulsatile and circadian patterns of PRL release were studied in 11 insulin-dependent diabetic men by sampling blood every 10 min for 24 h and comparing the results to those obtained in 12 normal nondiabetic men. The diabetic men had a mean (±SE) 24-h serum PRL concentration of 5.5 ± 0.42 μg/ L, which was significantly lower than that in the nondiabetic men (9.3 ± 0.86; P = 0.0008). Quantitative Cluster analysis of pulsatile PRL time series revealed a normal pulse frequency, but decreased maximal peak amplitude (6.6 ± 0.5 vs. 11.8 ± 1.1 μg/ L; P = 0.0009), peak increment (2.6 ± 0.24 vs. 4.0 ± 0.3 μg/L; P = 0.009), peak area (126 ± 15 vs. 192 ± 19 μg/L·min; P = 0.03), and interpulse valley mean concentration (4.8 ± 0.4 vs. 8.6 ± 1.2 μg/L; P = 0.0007). PRL pulse incremental amplitude correlated significantly (r2 = 0.577; P = 0.007) and negatively with duration of disease. Fourier analysis disclosed a normal circadian rhythm of PRL release in diabetic men, with a mean circadian amplitude of 1.5 μg/L ± 0.31, which peaked at 0201 h ± 89 min (±SE). In summary, we have demonstrated significantly reduced mean 24-h serum PRL concentrations in men with poorly controlled insulin-dependent diabetes mellitus. The concomitant suppression of spontaneous PRL pulse amplitude, peak increment, and interpulse valley mean concentrations in the presence of normal pulse frequency is consistent with a reduced mass of PRL secreted per burst and/or accelerated metabolic clearance of PRL in men with type I diabetes mellitus. (J Clin Endocrinol Metab 71: 73-78, 1990).",
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AU - Veldhuis, Johannes D

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AU - Booth, Robert A.

AU - Lizarralde, German

AU - Asplin, Christopher M.

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N2 - Pulsatile and circadian patterns of PRL release were studied in 11 insulin-dependent diabetic men by sampling blood every 10 min for 24 h and comparing the results to those obtained in 12 normal nondiabetic men. The diabetic men had a mean (±SE) 24-h serum PRL concentration of 5.5 ± 0.42 μg/ L, which was significantly lower than that in the nondiabetic men (9.3 ± 0.86; P = 0.0008). Quantitative Cluster analysis of pulsatile PRL time series revealed a normal pulse frequency, but decreased maximal peak amplitude (6.6 ± 0.5 vs. 11.8 ± 1.1 μg/ L; P = 0.0009), peak increment (2.6 ± 0.24 vs. 4.0 ± 0.3 μg/L; P = 0.009), peak area (126 ± 15 vs. 192 ± 19 μg/L·min; P = 0.03), and interpulse valley mean concentration (4.8 ± 0.4 vs. 8.6 ± 1.2 μg/L; P = 0.0007). PRL pulse incremental amplitude correlated significantly (r2 = 0.577; P = 0.007) and negatively with duration of disease. Fourier analysis disclosed a normal circadian rhythm of PRL release in diabetic men, with a mean circadian amplitude of 1.5 μg/L ± 0.31, which peaked at 0201 h ± 89 min (±SE). In summary, we have demonstrated significantly reduced mean 24-h serum PRL concentrations in men with poorly controlled insulin-dependent diabetes mellitus. The concomitant suppression of spontaneous PRL pulse amplitude, peak increment, and interpulse valley mean concentrations in the presence of normal pulse frequency is consistent with a reduced mass of PRL secreted per burst and/or accelerated metabolic clearance of PRL in men with type I diabetes mellitus. (J Clin Endocrinol Metab 71: 73-78, 1990).

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