Atrial natriuretic peptide elevation in congestive heart failure in the human

John C Jr. Burnett, P. C. Kao, D. C. Hu, D. W. Heser, D. Heublein, J. P. Granger, T. J. Opgenorth, G. S. Reeder

Research output: Contribution to journalArticle

717 Citations (Scopus)

Abstract

A sensitive radioimmunoassay for atrial natriuretic peptide was used to examine the relation between circulating atrial natriuretic peptide and cardiac filling pressure in normal human subjects, in patients with cardiovascular disease and normal cardiac filling pressure, and in patients with cardiovascular disease and elevated cardiac filling presure with and without congestive heart failure. The present studies establish a normal range for atrial natriuretic peptide in normal human subjects. These studies also establish that elevated cardiac filling pressure is associated with increased circulating concentrations of atrial natriuretic peptide and that congestive heart failure is not characterized by a deficiency in atrial natriuretic peptide, but with its elevation.

Original languageEnglish (US)
Pages (from-to)1145-1147
Number of pages3
JournalScience
Volume231
Issue number4742
DOIs
StatePublished - 1986

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Atrial Natriuretic Factor
Heart Failure
Pressure
Cardiovascular Diseases
Radioimmunoassay
Reference Values

ASJC Scopus subject areas

  • General

Cite this

Burnett, J. C. J., Kao, P. C., Hu, D. C., Heser, D. W., Heublein, D., Granger, J. P., ... Reeder, G. S. (1986). Atrial natriuretic peptide elevation in congestive heart failure in the human. Science, 231(4742), 1145-1147. https://doi.org/10.1126/science.2935937

Atrial natriuretic peptide elevation in congestive heart failure in the human. / Burnett, John C Jr.; Kao, P. C.; Hu, D. C.; Heser, D. W.; Heublein, D.; Granger, J. P.; Opgenorth, T. J.; Reeder, G. S.

In: Science, Vol. 231, No. 4742, 1986, p. 1145-1147.

Research output: Contribution to journalArticle

Burnett, JCJ, Kao, PC, Hu, DC, Heser, DW, Heublein, D, Granger, JP, Opgenorth, TJ & Reeder, GS 1986, 'Atrial natriuretic peptide elevation in congestive heart failure in the human', Science, vol. 231, no. 4742, pp. 1145-1147. https://doi.org/10.1126/science.2935937
Burnett, John C Jr. ; Kao, P. C. ; Hu, D. C. ; Heser, D. W. ; Heublein, D. ; Granger, J. P. ; Opgenorth, T. J. ; Reeder, G. S. / Atrial natriuretic peptide elevation in congestive heart failure in the human. In: Science. 1986 ; Vol. 231, No. 4742. pp. 1145-1147.
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