Atrial fibrillation, cognitive impairment, and neuroimaging

Jonathan Graff-Radford; Malini Madhavan; Prashanthi Vemuri; Alejandro A. Rabinstein; Ruth H. Cha; Michelle M. Mielke; Kejal Kantarci; Val Lowe; Matthew L. Senjem; Jeffrey L. Gunter; David S. Knopman; Ronald C. Petersen; Clifford R. Jack; Rosebud O. Roberts

doi:10.1016/j.jalz.2015.08.164

Atrial fibrillation, cognitive impairment, and neuroimaging

Jonathan Graff-Radford, Malini Madhavan, Prashanthi Vemuri, Alejandro A. Rabinstein, Ruth H. Cha, Michelle M. Mielke, Kejal Kantarci, Val Lowe, Matthew L. Senjem, Jeffrey L. Gunter, David S. Knopman, Ronald C. Petersen, Clifford R. Jack, Rosebud O. Roberts

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Introduction The objective of our study was to investigate cross-sectional associations of atrial fibrillation with neuroimaging measures of cerebrovascular disease and Alzheimer's disease and their interactions with mild cognitive impairment (MCI). Methods Magnetic resonance imaging scans of individuals from a population-based study were analyzed for infarctions, total gray matter, and hippocampal and white matter hyperintensity volumes. A subsample underwent positron emission tomography imaging. Results Atrial fibrillation was associated with infarctions and lower total gray matter volume. Compared with subjects with no atrial fibrillation and no infarction, the odds ratio (95% confidence intervals) for MCI was 2.99 (1.57-5.70; P =.001) among participants with atrial fibrillation and infarction, 0.90 (0.45-1.80; P =.77) for atrial fibrillation and no infarction, and 1.50 (0.96-2.34; P =.08) for no atrial fibrillation and any infarction. Discussion Participants with both atrial fibrillation and infarction are more likely to have MCI than participants with either infarction or atrial fibrillation alone.

Original language	English (US)
Pages (from-to)	391-398
Number of pages	8
Journal	Alzheimer's and Dementia
Volume	12
Issue number	4
DOIs	https://doi.org/10.1016/j.jalz.2015.08.164
State	Published - Apr 1 2016

Keywords

Alzheimer's disease
Atrial fibrillation
Cerebrovascular disease
Mild cognitive impairment
Stroke

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Psychiatry and Mental health
Cellular and Molecular Neuroscience

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Atrial fibrillation, cognitive impairment, and neuroimaging. / Graff-Radford, Jonathan; Madhavan, Malini; Vemuri, Prashanthi ; Rabinstein, Alejandro A.; Cha, Ruth H.; Mielke, Michelle M.; Kantarci, Kejal ; Lowe, Val; Senjem, Matthew L.; Gunter, Jeffrey L.; Knopman, David S.; Petersen, Ronald C.; Jack, Clifford R.; Roberts, Rosebud O.

In: Alzheimer's and Dementia, Vol. 12, No. 4, 01.04.2016, p. 391-398.

Research output: Contribution to journal › Article › peer-review

Graff-Radford, Jonathan ; Madhavan, Malini ; Vemuri, Prashanthi ; Rabinstein, Alejandro A. ; Cha, Ruth H. ; Mielke, Michelle M. ; Kantarci, Kejal ; Lowe, Val ; Senjem, Matthew L. ; Gunter, Jeffrey L. ; Knopman, David S. ; Petersen, Ronald C. ; Jack, Clifford R. ; Roberts, Rosebud O. / Atrial fibrillation, cognitive impairment, and neuroimaging. In: Alzheimer's and Dementia. 2016 ; Vol. 12, No. 4. pp. 391-398.

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abstract = "Introduction The objective of our study was to investigate cross-sectional associations of atrial fibrillation with neuroimaging measures of cerebrovascular disease and Alzheimer's disease and their interactions with mild cognitive impairment (MCI). Methods Magnetic resonance imaging scans of individuals from a population-based study were analyzed for infarctions, total gray matter, and hippocampal and white matter hyperintensity volumes. A subsample underwent positron emission tomography imaging. Results Atrial fibrillation was associated with infarctions and lower total gray matter volume. Compared with subjects with no atrial fibrillation and no infarction, the odds ratio (95% confidence intervals) for MCI was 2.99 (1.57-5.70; P =.001) among participants with atrial fibrillation and infarction, 0.90 (0.45-1.80; P =.77) for atrial fibrillation and no infarction, and 1.50 (0.96-2.34; P =.08) for no atrial fibrillation and any infarction. Discussion Participants with both atrial fibrillation and infarction are more likely to have MCI than participants with either infarction or atrial fibrillation alone.",

keywords = "Alzheimer's disease, Atrial fibrillation, Cerebrovascular disease, Mild cognitive impairment, Stroke",

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note = "Funding Information: AcknowledgmentsThis work was supported in part by grants U01 AG06786 (Mayo Clinic Study of Aging) and P50 AG016574 (Mayo Alzheimer Center), and by funds from the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Program.",

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AU - Mielke, Michelle M.

AU - Kantarci, Kejal

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AU - Senjem, Matthew L.

AU - Gunter, Jeffrey L.

AU - Knopman, David S.

AU - Petersen, Ronald C.

AU - Jack, Clifford R.

AU - Roberts, Rosebud O.

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N2 - Introduction The objective of our study was to investigate cross-sectional associations of atrial fibrillation with neuroimaging measures of cerebrovascular disease and Alzheimer's disease and their interactions with mild cognitive impairment (MCI). Methods Magnetic resonance imaging scans of individuals from a population-based study were analyzed for infarctions, total gray matter, and hippocampal and white matter hyperintensity volumes. A subsample underwent positron emission tomography imaging. Results Atrial fibrillation was associated with infarctions and lower total gray matter volume. Compared with subjects with no atrial fibrillation and no infarction, the odds ratio (95% confidence intervals) for MCI was 2.99 (1.57-5.70; P =.001) among participants with atrial fibrillation and infarction, 0.90 (0.45-1.80; P =.77) for atrial fibrillation and no infarction, and 1.50 (0.96-2.34; P =.08) for no atrial fibrillation and any infarction. Discussion Participants with both atrial fibrillation and infarction are more likely to have MCI than participants with either infarction or atrial fibrillation alone.

AB - Introduction The objective of our study was to investigate cross-sectional associations of atrial fibrillation with neuroimaging measures of cerebrovascular disease and Alzheimer's disease and their interactions with mild cognitive impairment (MCI). Methods Magnetic resonance imaging scans of individuals from a population-based study were analyzed for infarctions, total gray matter, and hippocampal and white matter hyperintensity volumes. A subsample underwent positron emission tomography imaging. Results Atrial fibrillation was associated with infarctions and lower total gray matter volume. Compared with subjects with no atrial fibrillation and no infarction, the odds ratio (95% confidence intervals) for MCI was 2.99 (1.57-5.70; P =.001) among participants with atrial fibrillation and infarction, 0.90 (0.45-1.80; P =.77) for atrial fibrillation and no infarction, and 1.50 (0.96-2.34; P =.08) for no atrial fibrillation and any infarction. Discussion Participants with both atrial fibrillation and infarction are more likely to have MCI than participants with either infarction or atrial fibrillation alone.

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