Abstract
Introduction: The objective of our study was to investigate cross-sectional associations of atrial fibrillation with neuroimaging measures of cerebrovascular disease and Alzheimer's disease and their interactions with mild cognitive impairment (MCI). Methods: Magnetic resonance imaging scans of individuals from a population-based study were analyzed for infarctions, total gray matter, and hippocampal and white matter hyperintensity volumes. A subsample underwent positron emission tomography imaging. Results: Atrial fibrillation was associated with infarctions and lower total gray matter volume. Compared with subjects with no atrial fibrillation and no infarction, the odds ratio (95% confidence intervals) for MCI was 2.99 (1.57-5.70;. P = .001) among participants with atrial fibrillation and infarction, 0.90 (0.45-1.80;. P = .77) for atrial fibrillation and no infarction, and 1.50 (0.96-2.34;. P = .08) for no atrial fibrillation and any infarction. Discussion: Participants with both atrial fibrillation and infarction are more likely to have MCI than participants with either infarction or atrial fibrillation alone.
| Original language | English (US) |
|---|---|
| Journal | Alzheimer's and Dementia |
| DOIs | |
| State | Accepted/In press - 2015 |
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Keywords
- Alzheimer's disease
- Atrial fibrillation
- Cerebrovascular disease
- Mild cognitive impairment
- Stroke
ASJC Scopus subject areas
- Clinical Neurology
- Developmental Neuroscience
- Cellular and Molecular Neuroscience
- Psychiatry and Mental health
- Geriatrics and Gerontology
- Epidemiology
- Health Policy
Cite this
Atrial fibrillation, cognitive impairment, and neuroimaging. / Graff-Radford, Jonathan; Madhavan, Malini; Vemuri, Prashanthi D; Rabinstein, Alejandro; Cha, Ruth H.; Mielke, Michelle M; Kantarci, Kejal M; Lowe, Val; Senjem, Matthew L.; Gunter, Jeffrey L.; Knopman, David S; Petersen, Ronald Carl; Jack, Clifford R Jr.; Roberts, Rosebud O.
In: Alzheimer's and Dementia, 2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Atrial fibrillation, cognitive impairment, and neuroimaging
AU - Graff-Radford, Jonathan
AU - Madhavan, Malini
AU - Vemuri, Prashanthi D
AU - Rabinstein, Alejandro
AU - Cha, Ruth H.
AU - Mielke, Michelle M
AU - Kantarci, Kejal M
AU - Lowe, Val
AU - Senjem, Matthew L.
AU - Gunter, Jeffrey L.
AU - Knopman, David S
AU - Petersen, Ronald Carl
AU - Jack, Clifford R Jr.
AU - Roberts, Rosebud O
PY - 2015
Y1 - 2015
N2 - Introduction: The objective of our study was to investigate cross-sectional associations of atrial fibrillation with neuroimaging measures of cerebrovascular disease and Alzheimer's disease and their interactions with mild cognitive impairment (MCI). Methods: Magnetic resonance imaging scans of individuals from a population-based study were analyzed for infarctions, total gray matter, and hippocampal and white matter hyperintensity volumes. A subsample underwent positron emission tomography imaging. Results: Atrial fibrillation was associated with infarctions and lower total gray matter volume. Compared with subjects with no atrial fibrillation and no infarction, the odds ratio (95% confidence intervals) for MCI was 2.99 (1.57-5.70;. P = .001) among participants with atrial fibrillation and infarction, 0.90 (0.45-1.80;. P = .77) for atrial fibrillation and no infarction, and 1.50 (0.96-2.34;. P = .08) for no atrial fibrillation and any infarction. Discussion: Participants with both atrial fibrillation and infarction are more likely to have MCI than participants with either infarction or atrial fibrillation alone.
AB - Introduction: The objective of our study was to investigate cross-sectional associations of atrial fibrillation with neuroimaging measures of cerebrovascular disease and Alzheimer's disease and their interactions with mild cognitive impairment (MCI). Methods: Magnetic resonance imaging scans of individuals from a population-based study were analyzed for infarctions, total gray matter, and hippocampal and white matter hyperintensity volumes. A subsample underwent positron emission tomography imaging. Results: Atrial fibrillation was associated with infarctions and lower total gray matter volume. Compared with subjects with no atrial fibrillation and no infarction, the odds ratio (95% confidence intervals) for MCI was 2.99 (1.57-5.70;. P = .001) among participants with atrial fibrillation and infarction, 0.90 (0.45-1.80;. P = .77) for atrial fibrillation and no infarction, and 1.50 (0.96-2.34;. P = .08) for no atrial fibrillation and any infarction. Discussion: Participants with both atrial fibrillation and infarction are more likely to have MCI than participants with either infarction or atrial fibrillation alone.
KW - Alzheimer's disease
KW - Atrial fibrillation
KW - Cerebrovascular disease
KW - Mild cognitive impairment
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=84951038581&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84951038581&partnerID=8YFLogxK
U2 - 10.1016/j.jalz.2015.08.164
DO - 10.1016/j.jalz.2015.08.164
M3 - Article
C2 - 26607820
AN - SCOPUS:84951038581
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
SN - 1552-5260
ER -