Atrial fibrillation, cognitive impairment, and neuroimaging

Jonathan Graff-Radford; Malini Madhavan; Prashanthi D Vemuri; Alejandro Rabinstein; Ruth H. Cha; Michelle M Mielke; Kejal M Kantarci; Val Lowe; Matthew L. Senjem; Jeffrey L. Gunter; David S Knopman; Ronald Carl Petersen; Clifford R Jr. Jack; Rosebud O Roberts

doi:10.1016/j.jalz.2015.08.164

Atrial fibrillation, cognitive impairment, and neuroimaging

Jonathan Graff-Radford, Malini Madhavan, Prashanthi D Vemuri, Alejandro Rabinstein, Ruth H. Cha, Michelle M Mielke, Kejal M Kantarci, Val Lowe, Matthew L. Senjem, Jeffrey L. Gunter, David S Knopman, Ronald Carl Petersen, Clifford R Jr. Jack, Rosebud O Roberts

Research output: Contribution to journal › Article

30 Scopus citations

Abstract

Introduction: The objective of our study was to investigate cross-sectional associations of atrial fibrillation with neuroimaging measures of cerebrovascular disease and Alzheimer's disease and their interactions with mild cognitive impairment (MCI). Methods: Magnetic resonance imaging scans of individuals from a population-based study were analyzed for infarctions, total gray matter, and hippocampal and white matter hyperintensity volumes. A subsample underwent positron emission tomography imaging. Results: Atrial fibrillation was associated with infarctions and lower total gray matter volume. Compared with subjects with no atrial fibrillation and no infarction, the odds ratio (95% confidence intervals) for MCI was 2.99 (1.57-5.70;. P = .001) among participants with atrial fibrillation and infarction, 0.90 (0.45-1.80;. P = .77) for atrial fibrillation and no infarction, and 1.50 (0.96-2.34;. P = .08) for no atrial fibrillation and any infarction. Discussion: Participants with both atrial fibrillation and infarction are more likely to have MCI than participants with either infarction or atrial fibrillation alone.

Original language	English (US)
Journal	Alzheimer's and Dementia
DOIs	https://doi.org/10.1016/j.jalz.2015.08.164
State	Accepted/In press - 2015

Keywords

Alzheimer's disease
Atrial fibrillation
Cerebrovascular disease
Mild cognitive impairment
Stroke

ASJC Scopus subject areas

Clinical Neurology
Developmental Neuroscience
Cellular and Molecular Neuroscience
Psychiatry and Mental health
Geriatrics and Gerontology
Epidemiology
Health Policy

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Graff-Radford, J., Madhavan, M., Vemuri, P. D., Rabinstein, A., Cha, R. H., Mielke, M. M., Kantarci, K. M., Lowe, V., Senjem, M. L., Gunter, J. L., Knopman, D. S., Petersen, R. C., Jack, C. R. J., & Roberts, R. O. (Accepted/In press). Atrial fibrillation, cognitive impairment, and neuroimaging. Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2015.08.164

Atrial fibrillation, cognitive impairment, and neuroimaging. / Graff-Radford, Jonathan; Madhavan, Malini; Vemuri, Prashanthi D ; Rabinstein, Alejandro; Cha, Ruth H.; Mielke, Michelle M ; Kantarci, Kejal M ; Lowe, Val; Senjem, Matthew L.; Gunter, Jeffrey L.; Knopman, David S ; Petersen, Ronald Carl ; Jack, Clifford R Jr.; Roberts, Rosebud O.

In: Alzheimer's and Dementia, 2015.

Research output: Contribution to journal › Article

Graff-Radford, Jonathan ; Madhavan, Malini ; Vemuri, Prashanthi D ; Rabinstein, Alejandro ; Cha, Ruth H. ; Mielke, Michelle M ; Kantarci, Kejal M ; Lowe, Val ; Senjem, Matthew L. ; Gunter, Jeffrey L. ; Knopman, David S ; Petersen, Ronald Carl ; Jack, Clifford R Jr. ; Roberts, Rosebud O. / Atrial fibrillation, cognitive impairment, and neuroimaging. In: Alzheimer's and Dementia. 2015.

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