Atrial fibrillation, cognitive impairment, and neuroimaging

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22 Citations (Scopus)

Abstract

Introduction: The objective of our study was to investigate cross-sectional associations of atrial fibrillation with neuroimaging measures of cerebrovascular disease and Alzheimer's disease and their interactions with mild cognitive impairment (MCI). Methods: Magnetic resonance imaging scans of individuals from a population-based study were analyzed for infarctions, total gray matter, and hippocampal and white matter hyperintensity volumes. A subsample underwent positron emission tomography imaging. Results: Atrial fibrillation was associated with infarctions and lower total gray matter volume. Compared with subjects with no atrial fibrillation and no infarction, the odds ratio (95% confidence intervals) for MCI was 2.99 (1.57-5.70;. P = .001) among participants with atrial fibrillation and infarction, 0.90 (0.45-1.80;. P = .77) for atrial fibrillation and no infarction, and 1.50 (0.96-2.34;. P = .08) for no atrial fibrillation and any infarction. Discussion: Participants with both atrial fibrillation and infarction are more likely to have MCI than participants with either infarction or atrial fibrillation alone.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
DOIs
StateAccepted/In press - 2015

Fingerprint

Neuroimaging
Atrial Fibrillation
Infarction
Cerebrovascular Disorders
Cognitive Dysfunction
Positron-Emission Tomography
Alzheimer Disease
Odds Ratio
Magnetic Resonance Imaging
Confidence Intervals
Population

Keywords

  • Alzheimer's disease
  • Atrial fibrillation
  • Cerebrovascular disease
  • Mild cognitive impairment
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Epidemiology
  • Health Policy

Cite this

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title = "Atrial fibrillation, cognitive impairment, and neuroimaging",
abstract = "Introduction: The objective of our study was to investigate cross-sectional associations of atrial fibrillation with neuroimaging measures of cerebrovascular disease and Alzheimer's disease and their interactions with mild cognitive impairment (MCI). Methods: Magnetic resonance imaging scans of individuals from a population-based study were analyzed for infarctions, total gray matter, and hippocampal and white matter hyperintensity volumes. A subsample underwent positron emission tomography imaging. Results: Atrial fibrillation was associated with infarctions and lower total gray matter volume. Compared with subjects with no atrial fibrillation and no infarction, the odds ratio (95{\%} confidence intervals) for MCI was 2.99 (1.57-5.70;. P = .001) among participants with atrial fibrillation and infarction, 0.90 (0.45-1.80;. P = .77) for atrial fibrillation and no infarction, and 1.50 (0.96-2.34;. P = .08) for no atrial fibrillation and any infarction. Discussion: Participants with both atrial fibrillation and infarction are more likely to have MCI than participants with either infarction or atrial fibrillation alone.",
keywords = "Alzheimer's disease, Atrial fibrillation, Cerebrovascular disease, Mild cognitive impairment, Stroke",
author = "Jonathan Graff-Radford and Malini Madhavan and Vemuri, {Prashanthi D} and Alejandro Rabinstein and Cha, {Ruth H.} and Mielke, {Michelle M} and Kantarci, {Kejal M} and Val Lowe and Senjem, {Matthew L.} and Gunter, {Jeffrey L.} and Knopman, {David S} and Petersen, {Ronald Carl} and Jack, {Clifford R Jr.} and Roberts, {Rosebud O}",
year = "2015",
doi = "10.1016/j.jalz.2015.08.164",
language = "English (US)",
journal = "Alzheimer's and Dementia",
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T1 - Atrial fibrillation, cognitive impairment, and neuroimaging

AU - Graff-Radford, Jonathan

AU - Madhavan, Malini

AU - Vemuri, Prashanthi D

AU - Rabinstein, Alejandro

AU - Cha, Ruth H.

AU - Mielke, Michelle M

AU - Kantarci, Kejal M

AU - Lowe, Val

AU - Senjem, Matthew L.

AU - Gunter, Jeffrey L.

AU - Knopman, David S

AU - Petersen, Ronald Carl

AU - Jack, Clifford R Jr.

AU - Roberts, Rosebud O

PY - 2015

Y1 - 2015

N2 - Introduction: The objective of our study was to investigate cross-sectional associations of atrial fibrillation with neuroimaging measures of cerebrovascular disease and Alzheimer's disease and their interactions with mild cognitive impairment (MCI). Methods: Magnetic resonance imaging scans of individuals from a population-based study were analyzed for infarctions, total gray matter, and hippocampal and white matter hyperintensity volumes. A subsample underwent positron emission tomography imaging. Results: Atrial fibrillation was associated with infarctions and lower total gray matter volume. Compared with subjects with no atrial fibrillation and no infarction, the odds ratio (95% confidence intervals) for MCI was 2.99 (1.57-5.70;. P = .001) among participants with atrial fibrillation and infarction, 0.90 (0.45-1.80;. P = .77) for atrial fibrillation and no infarction, and 1.50 (0.96-2.34;. P = .08) for no atrial fibrillation and any infarction. Discussion: Participants with both atrial fibrillation and infarction are more likely to have MCI than participants with either infarction or atrial fibrillation alone.

AB - Introduction: The objective of our study was to investigate cross-sectional associations of atrial fibrillation with neuroimaging measures of cerebrovascular disease and Alzheimer's disease and their interactions with mild cognitive impairment (MCI). Methods: Magnetic resonance imaging scans of individuals from a population-based study were analyzed for infarctions, total gray matter, and hippocampal and white matter hyperintensity volumes. A subsample underwent positron emission tomography imaging. Results: Atrial fibrillation was associated with infarctions and lower total gray matter volume. Compared with subjects with no atrial fibrillation and no infarction, the odds ratio (95% confidence intervals) for MCI was 2.99 (1.57-5.70;. P = .001) among participants with atrial fibrillation and infarction, 0.90 (0.45-1.80;. P = .77) for atrial fibrillation and no infarction, and 1.50 (0.96-2.34;. P = .08) for no atrial fibrillation and any infarction. Discussion: Participants with both atrial fibrillation and infarction are more likely to have MCI than participants with either infarction or atrial fibrillation alone.

KW - Alzheimer's disease

KW - Atrial fibrillation

KW - Cerebrovascular disease

KW - Mild cognitive impairment

KW - Stroke

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