Atlas of Transcription Factor Binding Sites from ENCODE DNase Hypersensitivity Data across 27 Tissue Types

Cory C. Funk, Alex M. Casella, Segun Jung, Matthew A. Richards, Alex Rodriguez, Paul Shannon, Rory Donovan-Maiye, Ben Heavner, Kyle Chard, Yukai Xiao, Gustavo Glusman, Nilufer Ertekin-Taner, Todd E. Golde, Arthur Toga, Leroy Hood, John D. Van Horn, Carl Kesselman, Ian Foster, Ravi Madduri, Nathan D. PriceSeth A. Ament

Research output: Contribution to journalArticlepeer-review

Abstract

DNase-seq footprinting provides a means to predict genome-wide binding sites for hundreds of transcription factors (TFs) simultaneously. Funk et al. analyze data from the ENCODE consortium to create a resource of footprints in 27 human tissues, demonstrating associations of tissue-specific TF occupancy with gene regulation and disease risk.

Original languageEnglish (US)
Article number108029
JournalCell reports
Volume32
Issue number7
DOIs
StatePublished - Aug 18 2020

Keywords

  • DNase-seq
  • ENCODE
  • footprinting
  • gene regulation
  • motifs
  • psychiatric genetics
  • transcription factors

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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