Abstract
DNase-seq footprinting provides a means to predict genome-wide binding sites for hundreds of transcription factors (TFs) simultaneously. Funk et al. analyze data from the ENCODE consortium to create a resource of footprints in 27 human tissues, demonstrating associations of tissue-specific TF occupancy with gene regulation and disease risk.
Original language | English (US) |
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Article number | 108029 |
Journal | Cell reports |
Volume | 32 |
Issue number | 7 |
DOIs | |
State | Published - Aug 18 2020 |
Keywords
- DNase-seq
- ENCODE
- footprinting
- gene regulation
- motifs
- psychiatric genetics
- transcription factors
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology