Atherosclerotic plaque progression in carotid arteries

Monitoring with high-spatial-resolution MR imaging - Multicenter trial

Loïc Boussel, Sandeep Arora, Joseph Rapp, Brian Rutt, John III Huston, Dennis Parker, Chun Yuan, Hisham Bassiouny, David Saloner

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Purpose: To estimate the annualized rate of progression of vesselwall volume in the carotid arteries in 160 patients by using magnetic resonance (MR) imaging and to establish the fraction of studies that have acceptable image quality. Materials and Methods: The study procedures and consent forms were reviewed and approved by each site's institutional review board. All U.S. study sites conducted all phases of this study in compliance with HIPAA requirements. Written consent was obtained from each participant. One hundred sixty patients with greater than 50% narrowing of the diameter of the carotid artery were recruited at six centers for prospective imaging of the carotid arteries at baseline and 1 year later by using high-spatial-resolution, 1.5-T MR imaging. Studies with unacceptable image quality were excluded. Quantitative changes in atheroma volume were measured on unenhanced T1-weighted images. A multiple linear regression analysis was used to correlate progression with several clinical factors, including statin therapy. Results: All 160 patients completed both baseline and follow-up studies. Of these studies, 67.5% were deemed to have image quality that was acceptable for quantitative analysis. The causes of rejection were motion (46%), deep location of the carotid artery (22%), low bifurcation of the carotid artery (13%), and "other" (19%). The mean annual change in vessel-wall volume was 2.31% ± 10.88 (standard deviation) (P = .014). At 1-year follow-up, vesselwall volumes in patients not receiving statin therapy had increased faster compared with those in patients receiving statin therapy: 7.87% ± 13.58% vs 1.14% ± 9.9%, respectively (P = .029). Conclusion: Evaluation of results of a multicenter study indicates that quantitative evaluation of the progression of volume of extracranial carotid vessel walls is feasible with 1.5-T MR imaging despite limitations due to patient motion or habitus. In patients who had preexisting carotid disease, the rate of increase in vessel-wall volume was slower in patients receiving statin therapy.

Original languageEnglish (US)
Pages (from-to)789-796
Number of pages8
JournalRadiology
Volume252
Issue number3
DOIs
StatePublished - Sep 2009

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Atherosclerotic Plaques
Carotid Arteries
Multicenter Studies
Magnetic Resonance Imaging
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Consent Forms
Health Insurance Portability and Accountability Act
Preexisting Condition Coverage
Carotid Stenosis
Research Ethics Committees
Therapeutics
Linear Models
Regression Analysis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Atherosclerotic plaque progression in carotid arteries : Monitoring with high-spatial-resolution MR imaging - Multicenter trial. / Boussel, Loïc; Arora, Sandeep; Rapp, Joseph; Rutt, Brian; Huston, John III; Parker, Dennis; Yuan, Chun; Bassiouny, Hisham; Saloner, David.

In: Radiology, Vol. 252, No. 3, 09.2009, p. 789-796.

Research output: Contribution to journalArticle

Boussel, L, Arora, S, Rapp, J, Rutt, B, Huston, JIII, Parker, D, Yuan, C, Bassiouny, H & Saloner, D 2009, 'Atherosclerotic plaque progression in carotid arteries: Monitoring with high-spatial-resolution MR imaging - Multicenter trial', Radiology, vol. 252, no. 3, pp. 789-796. https://doi.org/10.1148/radiol.2523081798
Boussel, Loïc ; Arora, Sandeep ; Rapp, Joseph ; Rutt, Brian ; Huston, John III ; Parker, Dennis ; Yuan, Chun ; Bassiouny, Hisham ; Saloner, David. / Atherosclerotic plaque progression in carotid arteries : Monitoring with high-spatial-resolution MR imaging - Multicenter trial. In: Radiology. 2009 ; Vol. 252, No. 3. pp. 789-796.
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AU - Rutt, Brian

AU - Huston, John III

AU - Parker, Dennis

AU - Yuan, Chun

AU - Bassiouny, Hisham

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