TY - JOUR
T1 - Atherosclerotic plaque progression in carotid arteries
T2 - Monitoring with high-spatial-resolution MR imaging - Multicenter trial
AU - Boussel, Loïc
AU - Arora, Sandeep
AU - Rapp, Joseph
AU - Rutt, Brian
AU - Huston, John
AU - Parker, Dennis
AU - Yuan, Chun
AU - Bassiouny, Hisham
AU - Saloner, David
PY - 2009/9
Y1 - 2009/9
N2 - Purpose: To estimate the annualized rate of progression of vesselwall volume in the carotid arteries in 160 patients by using magnetic resonance (MR) imaging and to establish the fraction of studies that have acceptable image quality. Materials and Methods: The study procedures and consent forms were reviewed and approved by each site's institutional review board. All U.S. study sites conducted all phases of this study in compliance with HIPAA requirements. Written consent was obtained from each participant. One hundred sixty patients with greater than 50% narrowing of the diameter of the carotid artery were recruited at six centers for prospective imaging of the carotid arteries at baseline and 1 year later by using high-spatial-resolution, 1.5-T MR imaging. Studies with unacceptable image quality were excluded. Quantitative changes in atheroma volume were measured on unenhanced T1-weighted images. A multiple linear regression analysis was used to correlate progression with several clinical factors, including statin therapy. Results: All 160 patients completed both baseline and follow-up studies. Of these studies, 67.5% were deemed to have image quality that was acceptable for quantitative analysis. The causes of rejection were motion (46%), deep location of the carotid artery (22%), low bifurcation of the carotid artery (13%), and "other" (19%). The mean annual change in vessel-wall volume was 2.31% ± 10.88 (standard deviation) (P = .014). At 1-year follow-up, vesselwall volumes in patients not receiving statin therapy had increased faster compared with those in patients receiving statin therapy: 7.87% ± 13.58% vs 1.14% ± 9.9%, respectively (P = .029). Conclusion: Evaluation of results of a multicenter study indicates that quantitative evaluation of the progression of volume of extracranial carotid vessel walls is feasible with 1.5-T MR imaging despite limitations due to patient motion or habitus. In patients who had preexisting carotid disease, the rate of increase in vessel-wall volume was slower in patients receiving statin therapy.
AB - Purpose: To estimate the annualized rate of progression of vesselwall volume in the carotid arteries in 160 patients by using magnetic resonance (MR) imaging and to establish the fraction of studies that have acceptable image quality. Materials and Methods: The study procedures and consent forms were reviewed and approved by each site's institutional review board. All U.S. study sites conducted all phases of this study in compliance with HIPAA requirements. Written consent was obtained from each participant. One hundred sixty patients with greater than 50% narrowing of the diameter of the carotid artery were recruited at six centers for prospective imaging of the carotid arteries at baseline and 1 year later by using high-spatial-resolution, 1.5-T MR imaging. Studies with unacceptable image quality were excluded. Quantitative changes in atheroma volume were measured on unenhanced T1-weighted images. A multiple linear regression analysis was used to correlate progression with several clinical factors, including statin therapy. Results: All 160 patients completed both baseline and follow-up studies. Of these studies, 67.5% were deemed to have image quality that was acceptable for quantitative analysis. The causes of rejection were motion (46%), deep location of the carotid artery (22%), low bifurcation of the carotid artery (13%), and "other" (19%). The mean annual change in vessel-wall volume was 2.31% ± 10.88 (standard deviation) (P = .014). At 1-year follow-up, vesselwall volumes in patients not receiving statin therapy had increased faster compared with those in patients receiving statin therapy: 7.87% ± 13.58% vs 1.14% ± 9.9%, respectively (P = .029). Conclusion: Evaluation of results of a multicenter study indicates that quantitative evaluation of the progression of volume of extracranial carotid vessel walls is feasible with 1.5-T MR imaging despite limitations due to patient motion or habitus. In patients who had preexisting carotid disease, the rate of increase in vessel-wall volume was slower in patients receiving statin therapy.
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U2 - 10.1148/radiol.2523081798
DO - 10.1148/radiol.2523081798
M3 - Article
C2 - 19508991
AN - SCOPUS:70349301520
SN - 0033-8419
VL - 252
SP - 789
EP - 796
JO - Radiology
JF - Radiology
IS - 3
ER -