We describe two siblings with asymmetric limb reduction malformations. Such anomalies are usually considered to result from sporadic events, but the recurrence in siblings without any identifiable teratogenic insult suggests a genetic etiology. This finding becomes important when parents are counseled about future pregnancies. The use of prenatal diagnostic techniques during subsequent pregnancies should be considered.
|Original language||English (US)|
|Number of pages||5|
|State||Published - 1984|
- Asymmetric skeletal malformation
- genetic counseling
- Mendelian inheritance
ASJC Scopus subject areas