Asymmetric skeletal anomalies in siblings

Wayne S. Stanley; Mason Barr Jr; Robert Hensinger; Stephen G. Ruby; Daniel L.Van Dyke; Lester Weiss

doi:10.1111/j.1399-0004.1984.tb00497.x

Asymmetric skeletal anomalies in siblings

Wayne S. Stanley, Mason Barr Jr, Robert Hensinger, Stephen G. Ruby, Daniel L.Van Dyke, Lester Weiss

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We describe two siblings with asymmetric limb reduction malformations. Such anomalies are usually considered to result from sporadic events, but the recurrence in siblings without any identifiable teratogenic insult suggests a genetic etiology. This finding becomes important when parents are counseled about future pregnancies. The use of prenatal diagnostic techniques during subsequent pregnancies should be considered.

Original language	English (US)
Pages (from-to)	533-537
Number of pages	5
Journal	Clinical Genetics
Volume	25
Issue number	6
DOIs	https://doi.org/10.1111/j.1399-0004.1984.tb00497.x
State	Published - Jun 1984

Keywords

Asymmetric skeletal malformation
Mendelian inheritance
genetic counseling

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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10.1111/j.1399-0004.1984.tb00497.x

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title = "Asymmetric skeletal anomalies in siblings",

abstract = "We describe two siblings with asymmetric limb reduction malformations. Such anomalies are usually considered to result from sporadic events, but the recurrence in siblings without any identifiable teratogenic insult suggests a genetic etiology. This finding becomes important when parents are counseled about future pregnancies. The use of prenatal diagnostic techniques during subsequent pregnancies should be considered.",

keywords = "Asymmetric skeletal malformation, Mendelian inheritance, genetic counseling",

author = "Stanley, {Wayne S.} and Jr, {Mason Barr} and Robert Hensinger and Ruby, {Stephen G.} and Dyke, {Daniel L.Van} and Lester Weiss",

year = "1984",

month = jun,

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AU - Stanley, Wayne S.

AU - Jr, Mason Barr

AU - Hensinger, Robert

AU - Ruby, Stephen G.

AU - Dyke, Daniel L.Van

AU - Weiss, Lester

PY - 1984/6

Y1 - 1984/6

N2 - We describe two siblings with asymmetric limb reduction malformations. Such anomalies are usually considered to result from sporadic events, but the recurrence in siblings without any identifiable teratogenic insult suggests a genetic etiology. This finding becomes important when parents are counseled about future pregnancies. The use of prenatal diagnostic techniques during subsequent pregnancies should be considered.

AB - We describe two siblings with asymmetric limb reduction malformations. Such anomalies are usually considered to result from sporadic events, but the recurrence in siblings without any identifiable teratogenic insult suggests a genetic etiology. This finding becomes important when parents are counseled about future pregnancies. The use of prenatal diagnostic techniques during subsequent pregnancies should be considered.

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KW - Mendelian inheritance

KW - genetic counseling

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ER -

Asymmetric skeletal anomalies in siblings

Abstract

Keywords

ASJC Scopus subject areas

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