Asymmetric cortical degenerative syndromes: Clinical and radiologic correlations

Research output: Contribution to journalArticle

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Abstract

Eight patients presented with slowly progressive focal neurologic syndromes that conformed to one of three clinically defined categories: progressive nonfluent aphasia (three patients), progressive perceptual-motor impairment (four patients), and progressive frontal lobe syndrome (one patient). Planar MRI and MRI-based surface or volume renderings demonstrated focal areas of atrophy that correlated well with clinical deficits. Single-photon emission computed tomography (SPECT) showed areas of cortical hypoperfusion that corresponded to focally atrophic regions revealed by MRI, but abnormal areas with SPECT were larger than those suggested by MRI. MRI and SPECT are useful in defining the regional structural and functional cerebral abnormalities that underlie slowly progressive focal neurologic syndromes caused by asymmetric cortical degeneration.

Original languageEnglish (US)
Pages (from-to)1462-1468
Number of pages7
JournalNeurology
Volume42
Issue number8
StatePublished - 1992

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Single-Photon Emission-Computed Tomography
Nervous System
Primary Progressive Nonfluent Aphasia
Frontal Lobe
Atrophy

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Asymmetric cortical degenerative syndromes : Clinical and radiologic correlations. / Caselli, Richard John; Jack, Clifford R Jr.; Petersen, Ronald Carl; Wahner, H. W.; Yanagihara, T.

In: Neurology, Vol. 42, No. 8, 1992, p. 1462-1468.

Research output: Contribution to journalArticle

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