Asthma and severity of the 2009 novel H1N1 influenza

A case-control study

Yong Bum Park, Changhwan Kim, Yong Il Hwang, Chang Lyul Lee, Won Yeon Lee, Hye Yun Park, Jin Won Heo, Hyun Kyung Lee, Jae Hwa Cho, Yong Soo Kwon, Ji Ye Jung, Young J Juhn, Barbara P. Yawn, Kent R Bailey, Kwang Ha Yoo

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: Previous studies reported that the most common chronic condition found among hospitalized patients due to the novel 2009 H1N1 influenza was asthma. However, these studies did not include a concurrent control group. Thus, we investigated the association of asthma status and severity of H1N1 influenza in adults. Methods: The study was designed as a multi-site case-control study. Cases were patients who had positive PCR for H1N1 influenza and were admitted to the ICU or general ward with a diagnosis of H1N1 influenza from 1 January 2009 to 31 December 2009. Controls were patients who had positive PCR for H1N1 influenza, but were not admitted to hospitals. Results: There were 91 H1N1 cases admitted to either ICU (n = 41) or general hospital ward (n = 50), and 56 controls who met the matching criteria were available. Of the 91 cases, the mean age was 47.3 years, 59% were female, and 38% had comorbid conditions. Of the 91 cases, 12 (13%) had asthma. Stratified analysis by comorbid conditions showed that among those without any comorbid conditions, 8 of 56 cases (14%) and 2 of 49 controls (4%) had asthma, (OR: 3.92, 95% CI: 0.79-19.42, p = 0.095) whereas, among the 39 subjects with one or more comorbid conditions, one of 7 controls (14%) had asthma and 4 of 35 (11%) cases had asthma (p = 0.83). Conclusions: Asthma may be associated with severity of H1N1 influenza among those without any non-asthma comorbid conditions. However, the limited sample size did not allow this study to fully establish statistical significance. We still recommend asthmatics as a priority group for influenza vaccination and treatment.

Original languageEnglish (US)
Pages (from-to)69-74
Number of pages6
JournalJournal of Asthma
Volume51
Issue number1
DOIs
StatePublished - Feb 2014

Fingerprint

Human Influenza
Case-Control Studies
Asthma
Patients' Rooms
Polymerase Chain Reaction
General Hospitals
Sample Size
Vaccination
Control Groups

Keywords

  • Asthma
  • Comorbid
  • H1N1 influenza
  • Severity

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Immunology and Allergy
  • Pediatrics, Perinatology, and Child Health

Cite this

Park, Y. B., Kim, C., Hwang, Y. I., Lee, C. L., Lee, W. Y., Park, H. Y., ... Yoo, K. H. (2014). Asthma and severity of the 2009 novel H1N1 influenza: A case-control study. Journal of Asthma, 51(1), 69-74. https://doi.org/10.3109/02770903.2013.838257

Asthma and severity of the 2009 novel H1N1 influenza : A case-control study. / Park, Yong Bum; Kim, Changhwan; Hwang, Yong Il; Lee, Chang Lyul; Lee, Won Yeon; Park, Hye Yun; Heo, Jin Won; Lee, Hyun Kyung; Cho, Jae Hwa; Kwon, Yong Soo; Jung, Ji Ye; Juhn, Young J; Yawn, Barbara P.; Bailey, Kent R; Yoo, Kwang Ha.

In: Journal of Asthma, Vol. 51, No. 1, 02.2014, p. 69-74.

Research output: Contribution to journalArticle

Park, YB, Kim, C, Hwang, YI, Lee, CL, Lee, WY, Park, HY, Heo, JW, Lee, HK, Cho, JH, Kwon, YS, Jung, JY, Juhn, YJ, Yawn, BP, Bailey, KR & Yoo, KH 2014, 'Asthma and severity of the 2009 novel H1N1 influenza: A case-control study', Journal of Asthma, vol. 51, no. 1, pp. 69-74. https://doi.org/10.3109/02770903.2013.838257
Park, Yong Bum ; Kim, Changhwan ; Hwang, Yong Il ; Lee, Chang Lyul ; Lee, Won Yeon ; Park, Hye Yun ; Heo, Jin Won ; Lee, Hyun Kyung ; Cho, Jae Hwa ; Kwon, Yong Soo ; Jung, Ji Ye ; Juhn, Young J ; Yawn, Barbara P. ; Bailey, Kent R ; Yoo, Kwang Ha. / Asthma and severity of the 2009 novel H1N1 influenza : A case-control study. In: Journal of Asthma. 2014 ; Vol. 51, No. 1. pp. 69-74.
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AU - Heo, Jin Won

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