Asthma and proinflammatory conditions: A population-based retrospective matched cohort study

Hyun D. Yun, Erin Knoebel, Yilma Fenta, Sherine E. Gabriel, Cynthia L. Leibson, Edward Vincent Loftus, Jr, Veronique Lee Roger, Barbara P. Yawn, Bill Li, Young J Juhn

Research output: Contribution to journalArticle

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Abstract

Objective: To determine the association between asthma and proinflammatory conditions. Participants and Methods: This population-based retrospective matched cohort study enrolled all asthmatic patients among Rochester, Minnesota, residents between January 1, 1964, and December 31, 1983. For each asthmatic patient, 2 age-and sex-matched nonasthmatic individuals were drawn from the same population. The asthmatic and nonasthmatic cohorts were followed forward in the Rochester Epidemiology Project diagnostic index for inflammatory bowel disease (IBD), rheumatoid arthritis (RA), diabetes mellitus (DM), and coronary heart disease (CHD) as outcome events. Data were fitted to Cox proportional hazards models. Results: We identified 2392 asthmatic patients and 4784 nonasthmatic controls. Of the asthmatic patients, 1356 (57%) were male, and mean age at asthma onset was 15.1 years. Incidence rates of IBD, RA, DM, and CHD in nonasthmatic controls were 32.8, 175.9, 132.0, and 389.7 per 100,000 person-years, respectively; those for asthmatic patients were 41.4, 227.9, 282.6, and 563.7 per 100,000 person-years, respectively. Asthma was associated with increased risks of DM (hazard ratio, 2.11; 95% confidence interval, 1.43-3.13; P<.001) and CHD (hazard ratio, 1.47; 95% confidence interval, 1.05-2.06; P=.02) but not with increased risks of IBD or RA. Conclusion: Although asthma is a helper T cell type 2-predominant condition, it may increase the risks of helper T cell type 1-polarized proinflammatory conditions, such as CHD and DM. Physicians who care for asthmatic patients need to address these unrecognized risks in asthmatic patients.

Original languageEnglish (US)
Pages (from-to)953-960
Number of pages8
JournalMayo Clinic Proceedings
Volume87
Issue number10
DOIs
StatePublished - Oct 2012

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Cohort Studies
Asthma
Coronary Disease
Diabetes Mellitus
Inflammatory Bowel Diseases
Population
Rheumatoid Arthritis
Confidence Intervals
Th2 Cells
Th1 Cells
Age of Onset
Proportional Hazards Models
Patient Care
Epidemiology
Physicians
Incidence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Asthma and proinflammatory conditions : A population-based retrospective matched cohort study. / Yun, Hyun D.; Knoebel, Erin; Fenta, Yilma; Gabriel, Sherine E.; Leibson, Cynthia L.; Loftus, Jr, Edward Vincent; Roger, Veronique Lee; Yawn, Barbara P.; Li, Bill; Juhn, Young J.

In: Mayo Clinic Proceedings, Vol. 87, No. 10, 10.2012, p. 953-960.

Research output: Contribution to journalArticle

Yun, Hyun D. ; Knoebel, Erin ; Fenta, Yilma ; Gabriel, Sherine E. ; Leibson, Cynthia L. ; Loftus, Jr, Edward Vincent ; Roger, Veronique Lee ; Yawn, Barbara P. ; Li, Bill ; Juhn, Young J. / Asthma and proinflammatory conditions : A population-based retrospective matched cohort study. In: Mayo Clinic Proceedings. 2012 ; Vol. 87, No. 10. pp. 953-960.
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abstract = "Objective: To determine the association between asthma and proinflammatory conditions. Participants and Methods: This population-based retrospective matched cohort study enrolled all asthmatic patients among Rochester, Minnesota, residents between January 1, 1964, and December 31, 1983. For each asthmatic patient, 2 age-and sex-matched nonasthmatic individuals were drawn from the same population. The asthmatic and nonasthmatic cohorts were followed forward in the Rochester Epidemiology Project diagnostic index for inflammatory bowel disease (IBD), rheumatoid arthritis (RA), diabetes mellitus (DM), and coronary heart disease (CHD) as outcome events. Data were fitted to Cox proportional hazards models. Results: We identified 2392 asthmatic patients and 4784 nonasthmatic controls. Of the asthmatic patients, 1356 (57{\%}) were male, and mean age at asthma onset was 15.1 years. Incidence rates of IBD, RA, DM, and CHD in nonasthmatic controls were 32.8, 175.9, 132.0, and 389.7 per 100,000 person-years, respectively; those for asthmatic patients were 41.4, 227.9, 282.6, and 563.7 per 100,000 person-years, respectively. Asthma was associated with increased risks of DM (hazard ratio, 2.11; 95{\%} confidence interval, 1.43-3.13; P<.001) and CHD (hazard ratio, 1.47; 95{\%} confidence interval, 1.05-2.06; P=.02) but not with increased risks of IBD or RA. Conclusion: Although asthma is a helper T cell type 2-predominant condition, it may increase the risks of helper T cell type 1-polarized proinflammatory conditions, such as CHD and DM. Physicians who care for asthmatic patients need to address these unrecognized risks in asthmatic patients.",
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AU - Yun, Hyun D.

AU - Knoebel, Erin

AU - Fenta, Yilma

AU - Gabriel, Sherine E.

AU - Leibson, Cynthia L.

AU - Loftus, Jr, Edward Vincent

AU - Roger, Veronique Lee

AU - Yawn, Barbara P.

AU - Li, Bill

AU - Juhn, Young J

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N2 - Objective: To determine the association between asthma and proinflammatory conditions. Participants and Methods: This population-based retrospective matched cohort study enrolled all asthmatic patients among Rochester, Minnesota, residents between January 1, 1964, and December 31, 1983. For each asthmatic patient, 2 age-and sex-matched nonasthmatic individuals were drawn from the same population. The asthmatic and nonasthmatic cohorts were followed forward in the Rochester Epidemiology Project diagnostic index for inflammatory bowel disease (IBD), rheumatoid arthritis (RA), diabetes mellitus (DM), and coronary heart disease (CHD) as outcome events. Data were fitted to Cox proportional hazards models. Results: We identified 2392 asthmatic patients and 4784 nonasthmatic controls. Of the asthmatic patients, 1356 (57%) were male, and mean age at asthma onset was 15.1 years. Incidence rates of IBD, RA, DM, and CHD in nonasthmatic controls were 32.8, 175.9, 132.0, and 389.7 per 100,000 person-years, respectively; those for asthmatic patients were 41.4, 227.9, 282.6, and 563.7 per 100,000 person-years, respectively. Asthma was associated with increased risks of DM (hazard ratio, 2.11; 95% confidence interval, 1.43-3.13; P<.001) and CHD (hazard ratio, 1.47; 95% confidence interval, 1.05-2.06; P=.02) but not with increased risks of IBD or RA. Conclusion: Although asthma is a helper T cell type 2-predominant condition, it may increase the risks of helper T cell type 1-polarized proinflammatory conditions, such as CHD and DM. Physicians who care for asthmatic patients need to address these unrecognized risks in asthmatic patients.

AB - Objective: To determine the association between asthma and proinflammatory conditions. Participants and Methods: This population-based retrospective matched cohort study enrolled all asthmatic patients among Rochester, Minnesota, residents between January 1, 1964, and December 31, 1983. For each asthmatic patient, 2 age-and sex-matched nonasthmatic individuals were drawn from the same population. The asthmatic and nonasthmatic cohorts were followed forward in the Rochester Epidemiology Project diagnostic index for inflammatory bowel disease (IBD), rheumatoid arthritis (RA), diabetes mellitus (DM), and coronary heart disease (CHD) as outcome events. Data were fitted to Cox proportional hazards models. Results: We identified 2392 asthmatic patients and 4784 nonasthmatic controls. Of the asthmatic patients, 1356 (57%) were male, and mean age at asthma onset was 15.1 years. Incidence rates of IBD, RA, DM, and CHD in nonasthmatic controls were 32.8, 175.9, 132.0, and 389.7 per 100,000 person-years, respectively; those for asthmatic patients were 41.4, 227.9, 282.6, and 563.7 per 100,000 person-years, respectively. Asthma was associated with increased risks of DM (hazard ratio, 2.11; 95% confidence interval, 1.43-3.13; P<.001) and CHD (hazard ratio, 1.47; 95% confidence interval, 1.05-2.06; P=.02) but not with increased risks of IBD or RA. Conclusion: Although asthma is a helper T cell type 2-predominant condition, it may increase the risks of helper T cell type 1-polarized proinflammatory conditions, such as CHD and DM. Physicians who care for asthmatic patients need to address these unrecognized risks in asthmatic patients.

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