Association of the APOE, MTHFR and ACE genes polymorphisms and stroke in Zambian patients

Masharip Atadzhanov, Mwila H. Mwaba, Patrice N. Mukomena, Shabir Lakhi, Sruti Rayaprolu, Owen A. Ross, James F. Meschia

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The aim of the present study was to investigate the association of APOE, MTHFR and ACE polymorphisms with stroke in the Zambian population. We analyzed 41 stroke patients and 116 control subjects all of Zambian origin for associations between the genotype of the APOE, MTHFR and ACE polymorphisms and stroke. The APOE ε2ε4 genotype showed increased risk for hemorrhagic stroke (P<0.05) and also a high risk for ischemic stroke (P=0.05). There was complete absence of the APOE ε2ε2 and the MTHFR TT genotypes in the Zambian population. The difference between cases and controls was not significant for the other genetic variants when analyzed for relationship between stroke, stroke subtype and genotype. We show that genetic variation at the APOE locus affects susceptibility to stroke. No detectable association were observed for the MTHFR and ACE genotypes and stroke in the Zambian population.

Original languageEnglish (US)
Article numbere20
Pages (from-to)69-72
Number of pages4
JournalNeurology International
Volume5
Issue number4
DOIs
StatePublished - Nov 11 2013

Keywords

  • Intra-cerebral hemorrhage
  • Ischemic stroke
  • Outcome
  • Risks factors
  • Sub-Saharan Africa
  • Zambia

ASJC Scopus subject areas

  • Clinical Neurology

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