Association of the APOE, MTHFR and ACE genes polymorphisms and stroke in Zambian patients

Masharip Atadzhanov; Mwila H. Mwaba; Patrice N. Mukomena; Shabir Lakhi; Sruti Rayaprolu; Owen A. Ross; James F. Meschia

doi:10.4081/ni.2013.e20

Association of the APOE, MTHFR and ACE genes polymorphisms and stroke in Zambian patients

Masharip Atadzhanov, Mwila H. Mwaba, Patrice N. Mukomena, Shabir Lakhi, Sruti Rayaprolu, Owen A. Ross, James F. Meschia

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The aim of the present study was to investigate the association of APOE, MTHFR and ACE polymorphisms with stroke in the Zambian population. We analyzed 41 stroke patients and 116 control subjects all of Zambian origin for associations between the genotype of the APOE, MTHFR and ACE polymorphisms and stroke. The APOE ε2ε4 genotype showed increased risk for hemorrhagic stroke (P<0.05) and also a high risk for ischemic stroke (P=0.05). There was complete absence of the APOE ε2ε2 and the MTHFR TT genotypes in the Zambian population. The difference between cases and controls was not significant for the other genetic variants when analyzed for relationship between stroke, stroke subtype and genotype. We show that genetic variation at the APOE locus affects susceptibility to stroke. No detectable association were observed for the MTHFR and ACE genotypes and stroke in the Zambian population.

Original language	English (US)
Article number	e20
Pages (from-to)	69-72
Number of pages	4
Journal	Neurology International
Volume	5
Issue number	4
DOIs	https://doi.org/10.4081/ni.2013.e20
State	Published - Nov 11 2013

Keywords

Intra-cerebral hemorrhage
Ischemic stroke
Outcome
Risks factors
Sub-Saharan Africa
Zambia

ASJC Scopus subject areas

Clinical Neurology

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title = "Association of the APOE, MTHFR and ACE genes polymorphisms and stroke in Zambian patients",

abstract = "The aim of the present study was to investigate the association of APOE, MTHFR and ACE polymorphisms with stroke in the Zambian population. We analyzed 41 stroke patients and 116 control subjects all of Zambian origin for associations between the genotype of the APOE, MTHFR and ACE polymorphisms and stroke. The APOE ε2ε4 genotype showed increased risk for hemorrhagic stroke (P<0.05) and also a high risk for ischemic stroke (P=0.05). There was complete absence of the APOE ε2ε2 and the MTHFR TT genotypes in the Zambian population. The difference between cases and controls was not significant for the other genetic variants when analyzed for relationship between stroke, stroke subtype and genotype. We show that genetic variation at the APOE locus affects susceptibility to stroke. No detectable association were observed for the MTHFR and ACE genotypes and stroke in the Zambian population.",

keywords = "Intra-cerebral hemorrhage, Ischemic stroke, Outcome, Risks factors, Sub-Saharan Africa, Zambia",

author = "Masharip Atadzhanov and Mwaba, {Mwila H.} and Mukomena, {Patrice N.} and Shabir Lakhi and Sruti Rayaprolu and Ross, {Owen A.} and Meschia, {James F.}",

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AU - Atadzhanov, Masharip

AU - Mwaba, Mwila H.

AU - Mukomena, Patrice N.

AU - Lakhi, Shabir

AU - Rayaprolu, Sruti

AU - Ross, Owen A.

AU - Meschia, James F.

PY - 2013/11/11

Y1 - 2013/11/11

N2 - The aim of the present study was to investigate the association of APOE, MTHFR and ACE polymorphisms with stroke in the Zambian population. We analyzed 41 stroke patients and 116 control subjects all of Zambian origin for associations between the genotype of the APOE, MTHFR and ACE polymorphisms and stroke. The APOE ε2ε4 genotype showed increased risk for hemorrhagic stroke (P<0.05) and also a high risk for ischemic stroke (P=0.05). There was complete absence of the APOE ε2ε2 and the MTHFR TT genotypes in the Zambian population. The difference between cases and controls was not significant for the other genetic variants when analyzed for relationship between stroke, stroke subtype and genotype. We show that genetic variation at the APOE locus affects susceptibility to stroke. No detectable association were observed for the MTHFR and ACE genotypes and stroke in the Zambian population.

AB - The aim of the present study was to investigate the association of APOE, MTHFR and ACE polymorphisms with stroke in the Zambian population. We analyzed 41 stroke patients and 116 control subjects all of Zambian origin for associations between the genotype of the APOE, MTHFR and ACE polymorphisms and stroke. The APOE ε2ε4 genotype showed increased risk for hemorrhagic stroke (P<0.05) and also a high risk for ischemic stroke (P=0.05). There was complete absence of the APOE ε2ε2 and the MTHFR TT genotypes in the Zambian population. The difference between cases and controls was not significant for the other genetic variants when analyzed for relationship between stroke, stroke subtype and genotype. We show that genetic variation at the APOE locus affects susceptibility to stroke. No detectable association were observed for the MTHFR and ACE genotypes and stroke in the Zambian population.

KW - Intra-cerebral hemorrhage

KW - Ischemic stroke

KW - Outcome

KW - Risks factors

KW - Sub-Saharan Africa

KW - Zambia

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Association of the APOE, MTHFR and ACE genes polymorphisms and stroke in Zambian patients

Abstract

Keywords

ASJC Scopus subject areas

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