@article{3b738478971a4177a0c09c3d0d387c8a,
title = "Association of telomere length with general cognitive trajectories: a meta-analysis of four prospective cohort studies",
abstract = "To investigate the association of telomere length (TL) with trajectories of general cognitive abilities, we used data on 5955 participants from the Sex Differences in Health and Aging Study and the Swedish Adoption/Twin Study of Aging in Sweden, and the Mayo Clinic Study of Aging, and the Health and Retirement Study in the United States. TL was measured at baseline, while general cognitive ability was assessed repeatedly up to 7 occasions. Latent growth curve models were used to examine the associations. One standard deviation increase of TL was associated with 0.021 unit increase (95% confidence interval [CI]: 0.001, 0.042) of standardized mean general cognitive ability. After controlling for sex, the point estimate remained similar (0.019) with a wider CI (95% CI: −0.002, 0.039). The association was attenuated with adjustment for educational attainment (0.009, 95% CI: −0.009, 0.028). No strong evidence was observed for the association of TL and decline in general cognitive ability. Longer TL was associated with higher general cognitive ability levels in the age-adjusted models but not in the models including all covariates, nor with cognitive decline.",
keywords = "Biological aging, Cognition, Cognitive aging, Telomere",
author = "Yiqiang Zhan and Clements, {Mark S.} and Roberts, {Rosebud O} and Maria Vassilaki and Druliner, {Brooke R.} and Boardman, {Lisa A.} and Petersen, {Ronald C.} and Reynolds, {Chandra A.} and Pedersen, {Nancy L.} and Sara H{\"a}gg",
note = "Funding Information: The HRS study is sponsored by the National Institute on Aging (grant number NIA U01AG009740, RC4AG039029, R25AG053227) and is conducted by the University of Michigan. Funding Information: The Swedish Adoption/Twin Study of Aging and GENDER studies are supported by NIH grants R01 AG04563, AG10175, and AG028555, the MacArthur Foundation Research Network on Successful Aging, the Swedish Council for Working Life and Social Research (FAS/FORTE) (97:0147:1B, 2009-0795), and the Swedish Research Council (825-2007-7460, 825-2009–6141). This study is supported by the Swedish Research Council (521-2013-8689, 2015-03255), FORTE (2013-2292), the Karolinska Institutet delfinansiering (KID) for doctoral student, the Loo and Hans Osterman Foundation, and the Foundation for Geriatric Diseases, the Magnus Bergwall Foundation, and the Strategic Research Program in Epidemiology at Karolinska Institutet. The authors thank Iiris Hovatta for telomere assessment. Funding Information: The MCSA study is supported by the National Institute on Aging (U01 AG006786), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR30582), the Mayo Foundation for Medical Education and Research, and the Mayo Clinic Center for Individualized Medicine and was made possible by the Rochester Epidemiology Project (R01 AG034676). Work was also partially supported by an Alzheimer{\textquoteright}s Disease Research Center Pilot award (P50 AG016574). The authors thank Ruth Johnson for the laboratory work. Funding Information: ROR receives research funding from Roche and Biogen. MV receives research funding from Roche. RCP is a consultant for Roche, Inc; Merck, Inc; Genentech, Inc; Biogen, Inc. The other authors have no actual or potential conflicts of interest. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2018",
month = sep,
doi = "10.1016/j.neurobiolaging.2018.05.004",
language = "English (US)",
volume = "69",
pages = "111--116",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
}