Abstract
To investigate the association of telomere length (TL) with trajectories of general cognitive abilities, we used data on 5955 participants from the Sex Differences in Health and Aging Study and the Swedish Adoption/Twin Study of Aging in Sweden, and the Mayo Clinic Study of Aging, and the Health and Retirement Study in the United States. TL was measured at baseline, while general cognitive ability was assessed repeatedly up to 7 occasions. Latent growth curve models were used to examine the associations. One standard deviation increase of TL was associated with 0.021 unit increase (95% confidence interval [CI]: 0.001, 0.042) of standardized mean general cognitive ability. After controlling for sex, the point estimate remained similar (0.019) with a wider CI (95% CI: −0.002, 0.039). The association was attenuated with adjustment for educational attainment (0.009, 95% CI: −0.009, 0.028). No strong evidence was observed for the association of TL and decline in general cognitive ability. Longer TL was associated with higher general cognitive ability levels in the age-adjusted models but not in the models including all covariates, nor with cognitive decline.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 111-116 |
| Number of pages | 6 |
| Journal | Neurobiology of Aging |
| Volume | 69 |
| DOIs | |
| State | Published - Sep 1 2018 |
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Keywords
- Biological aging
- Cognition
- Cognitive aging
- Telomere
ASJC Scopus subject areas
- Neuroscience(all)
- Aging
- Clinical Neurology
- Developmental Biology
- Geriatrics and Gerontology
Cite this
Association of telomere length with general cognitive trajectories : a meta-analysis of four prospective cohort studies. / Zhan, Yiqiang; Clements, Mark S.; Roberts, Rosebud O; Vassilaki, Maria; Druliner, Brooke R.; Boardman, Lisa Allyn; Petersen, Ronald Carl; Reynolds, Chandra A.; Pedersen, Nancy L.; Hägg, Sara.
In: Neurobiology of Aging, Vol. 69, 01.09.2018, p. 111-116.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of telomere length with general cognitive trajectories
T2 - a meta-analysis of four prospective cohort studies
AU - Zhan, Yiqiang
AU - Clements, Mark S.
AU - Roberts, Rosebud O
AU - Vassilaki, Maria
AU - Druliner, Brooke R.
AU - Boardman, Lisa Allyn
AU - Petersen, Ronald Carl
AU - Reynolds, Chandra A.
AU - Pedersen, Nancy L.
AU - Hägg, Sara
PY - 2018/9/1
Y1 - 2018/9/1
N2 - To investigate the association of telomere length (TL) with trajectories of general cognitive abilities, we used data on 5955 participants from the Sex Differences in Health and Aging Study and the Swedish Adoption/Twin Study of Aging in Sweden, and the Mayo Clinic Study of Aging, and the Health and Retirement Study in the United States. TL was measured at baseline, while general cognitive ability was assessed repeatedly up to 7 occasions. Latent growth curve models were used to examine the associations. One standard deviation increase of TL was associated with 0.021 unit increase (95% confidence interval [CI]: 0.001, 0.042) of standardized mean general cognitive ability. After controlling for sex, the point estimate remained similar (0.019) with a wider CI (95% CI: −0.002, 0.039). The association was attenuated with adjustment for educational attainment (0.009, 95% CI: −0.009, 0.028). No strong evidence was observed for the association of TL and decline in general cognitive ability. Longer TL was associated with higher general cognitive ability levels in the age-adjusted models but not in the models including all covariates, nor with cognitive decline.
AB - To investigate the association of telomere length (TL) with trajectories of general cognitive abilities, we used data on 5955 participants from the Sex Differences in Health and Aging Study and the Swedish Adoption/Twin Study of Aging in Sweden, and the Mayo Clinic Study of Aging, and the Health and Retirement Study in the United States. TL was measured at baseline, while general cognitive ability was assessed repeatedly up to 7 occasions. Latent growth curve models were used to examine the associations. One standard deviation increase of TL was associated with 0.021 unit increase (95% confidence interval [CI]: 0.001, 0.042) of standardized mean general cognitive ability. After controlling for sex, the point estimate remained similar (0.019) with a wider CI (95% CI: −0.002, 0.039). The association was attenuated with adjustment for educational attainment (0.009, 95% CI: −0.009, 0.028). No strong evidence was observed for the association of TL and decline in general cognitive ability. Longer TL was associated with higher general cognitive ability levels in the age-adjusted models but not in the models including all covariates, nor with cognitive decline.
KW - Biological aging
KW - Cognition
KW - Cognitive aging
KW - Telomere
UR - http://www.scopus.com/inward/record.url?scp=85047796815&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85047796815&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2018.05.004
DO - 10.1016/j.neurobiolaging.2018.05.004
M3 - Article
VL - 69
SP - 111
EP - 116
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
ER -