Association of sICAM-1 and MCP-1 with coronary artery calcification in families enriched for coronary heart disease or hypertension: The NHLBI Family Heart Study

Weihong Tang, James S. Pankow, J. Jeffrey carr, Russell P. Tracy, Suzette J Bielinski, Kari E. North, Paul N. Hopkins, Aldi T. Kraja, Donna K. Arnett

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Abstract

Background: Data accumulated from mouse studies and in vitro studies of human arteries support the notion that soluble intercellular adhesion molecule-1 (sICAM-1) and monocyte chemoattractant protein-1 (MCP-1) play important roles in the inflammation process involved in atherosclerosis. However, at the population level, the utility of sICAM-1 and MCP-1 as biomarkers for subclinical atherosclerosis is less clear. In the follow-up exam of the NHLBI Family Heart Study, we evaluated whether plasma levels of sICAM-1 and MCP-1 were associated with coronary artery calcification (CAC), a measure of the burden of coronary atherosclerosis. Methods: CAC was measured using the Agatston score with multidetector computed tomography. Information on CAC and MCP-1 was obtained in 2246 whites and 470 African Americans (mean age 55 years) without a history of coronary heart disease (CHD). Information on sICAM-1 was obtained for white participants only. Results: In whites, after adjustment for age and gender, the odds ratios (ORs) of CAC (CAC < 0) associated with the second, third, fourth, and fifth quintiles of sICAM-1 compared to the first quintile were 1.22 (95% confidence interval [CI]: 0.91 - 1.63), 1.15 (0.84 - 1.58), 1.49 (1.09 - 2.05), and 1.72 (1.26 - 2.36) (p = 0.0005 for trend test), respectively. The corresponding ORs for the second to fifth quintiles of MCP-1 were 1.26 (0.92 - 1.73), 0.99 (0.73 - 1.34), 1.42 (1.03 - 1.96), and 2.00 (1.43 - 2.79) (p < 0.0001 for trend test), respectively. In multivariable analysis that additionally adjusted for other CHD risk factors, the association of CAC with sICAM-1 and MCP-1 was attenuated and no longer statistically significant. In African Americans, the age and gender-adjusted ORs of CAC associated with the second and third tertiles of MCP-1 compared to the first tertile were 1.16 (0.64 - 2.08) and 1.25 (0.70 - 2.23) (p = 0.44 for trend test), respectively. This result did not change materially after additional adjustment for other CHD risk factors. Test of race interaction showed that the magnitude of association between MCP-1 and CAC did not differ significantly between African Americans and whites. Similar results were obtained when CAC ≥ 10 was analyzed as an outcome for both MCP-1 and sICAM-1. Conclusion: This study suggests that sICAM-1 and MCP-1 are biomarkers of coronary atherosclerotic burden and their association with CAC was mainly driven by established CHD risk factors.

Original languageEnglish (US)
Article number30
JournalBMC Cardiovascular Disorders
Volume7
DOIs
StatePublished - Oct 26 2007
Externally publishedYes

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National Heart, Lung, and Blood Institute (U.S.)
Chemokine CCL2
Intercellular Adhesion Molecule-1
Coronary Disease
Coronary Vessels
Hypertension
African Americans
Odds Ratio
Atherosclerosis
Biomarkers
Multidetector Computed Tomography
Coronary Artery Disease
Arteries
Confidence Intervals
Inflammation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Association of sICAM-1 and MCP-1 with coronary artery calcification in families enriched for coronary heart disease or hypertension : The NHLBI Family Heart Study. / Tang, Weihong; Pankow, James S.; carr, J. Jeffrey; Tracy, Russell P.; Bielinski, Suzette J; North, Kari E.; Hopkins, Paul N.; Kraja, Aldi T.; Arnett, Donna K.

In: BMC Cardiovascular Disorders, Vol. 7, 30, 26.10.2007.

Research output: Contribution to journalArticle

Tang, Weihong ; Pankow, James S. ; carr, J. Jeffrey ; Tracy, Russell P. ; Bielinski, Suzette J ; North, Kari E. ; Hopkins, Paul N. ; Kraja, Aldi T. ; Arnett, Donna K. / Association of sICAM-1 and MCP-1 with coronary artery calcification in families enriched for coronary heart disease or hypertension : The NHLBI Family Heart Study. In: BMC Cardiovascular Disorders. 2007 ; Vol. 7.
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title = "Association of sICAM-1 and MCP-1 with coronary artery calcification in families enriched for coronary heart disease or hypertension: The NHLBI Family Heart Study",
abstract = "Background: Data accumulated from mouse studies and in vitro studies of human arteries support the notion that soluble intercellular adhesion molecule-1 (sICAM-1) and monocyte chemoattractant protein-1 (MCP-1) play important roles in the inflammation process involved in atherosclerosis. However, at the population level, the utility of sICAM-1 and MCP-1 as biomarkers for subclinical atherosclerosis is less clear. In the follow-up exam of the NHLBI Family Heart Study, we evaluated whether plasma levels of sICAM-1 and MCP-1 were associated with coronary artery calcification (CAC), a measure of the burden of coronary atherosclerosis. Methods: CAC was measured using the Agatston score with multidetector computed tomography. Information on CAC and MCP-1 was obtained in 2246 whites and 470 African Americans (mean age 55 years) without a history of coronary heart disease (CHD). Information on sICAM-1 was obtained for white participants only. Results: In whites, after adjustment for age and gender, the odds ratios (ORs) of CAC (CAC < 0) associated with the second, third, fourth, and fifth quintiles of sICAM-1 compared to the first quintile were 1.22 (95{\%} confidence interval [CI]: 0.91 - 1.63), 1.15 (0.84 - 1.58), 1.49 (1.09 - 2.05), and 1.72 (1.26 - 2.36) (p = 0.0005 for trend test), respectively. The corresponding ORs for the second to fifth quintiles of MCP-1 were 1.26 (0.92 - 1.73), 0.99 (0.73 - 1.34), 1.42 (1.03 - 1.96), and 2.00 (1.43 - 2.79) (p < 0.0001 for trend test), respectively. In multivariable analysis that additionally adjusted for other CHD risk factors, the association of CAC with sICAM-1 and MCP-1 was attenuated and no longer statistically significant. In African Americans, the age and gender-adjusted ORs of CAC associated with the second and third tertiles of MCP-1 compared to the first tertile were 1.16 (0.64 - 2.08) and 1.25 (0.70 - 2.23) (p = 0.44 for trend test), respectively. This result did not change materially after additional adjustment for other CHD risk factors. Test of race interaction showed that the magnitude of association between MCP-1 and CAC did not differ significantly between African Americans and whites. Similar results were obtained when CAC ≥ 10 was analyzed as an outcome for both MCP-1 and sICAM-1. Conclusion: This study suggests that sICAM-1 and MCP-1 are biomarkers of coronary atherosclerotic burden and their association with CAC was mainly driven by established CHD risk factors.",
author = "Weihong Tang and Pankow, {James S.} and carr, {J. Jeffrey} and Tracy, {Russell P.} and Bielinski, {Suzette J} and North, {Kari E.} and Hopkins, {Paul N.} and Kraja, {Aldi T.} and Arnett, {Donna K.}",
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day = "26",
doi = "10.1186/1471-2261-7-30",
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TY - JOUR

T1 - Association of sICAM-1 and MCP-1 with coronary artery calcification in families enriched for coronary heart disease or hypertension

T2 - The NHLBI Family Heart Study

AU - Tang, Weihong

AU - Pankow, James S.

AU - carr, J. Jeffrey

AU - Tracy, Russell P.

AU - Bielinski, Suzette J

AU - North, Kari E.

AU - Hopkins, Paul N.

AU - Kraja, Aldi T.

AU - Arnett, Donna K.

PY - 2007/10/26

Y1 - 2007/10/26

N2 - Background: Data accumulated from mouse studies and in vitro studies of human arteries support the notion that soluble intercellular adhesion molecule-1 (sICAM-1) and monocyte chemoattractant protein-1 (MCP-1) play important roles in the inflammation process involved in atherosclerosis. However, at the population level, the utility of sICAM-1 and MCP-1 as biomarkers for subclinical atherosclerosis is less clear. In the follow-up exam of the NHLBI Family Heart Study, we evaluated whether plasma levels of sICAM-1 and MCP-1 were associated with coronary artery calcification (CAC), a measure of the burden of coronary atherosclerosis. Methods: CAC was measured using the Agatston score with multidetector computed tomography. Information on CAC and MCP-1 was obtained in 2246 whites and 470 African Americans (mean age 55 years) without a history of coronary heart disease (CHD). Information on sICAM-1 was obtained for white participants only. Results: In whites, after adjustment for age and gender, the odds ratios (ORs) of CAC (CAC < 0) associated with the second, third, fourth, and fifth quintiles of sICAM-1 compared to the first quintile were 1.22 (95% confidence interval [CI]: 0.91 - 1.63), 1.15 (0.84 - 1.58), 1.49 (1.09 - 2.05), and 1.72 (1.26 - 2.36) (p = 0.0005 for trend test), respectively. The corresponding ORs for the second to fifth quintiles of MCP-1 were 1.26 (0.92 - 1.73), 0.99 (0.73 - 1.34), 1.42 (1.03 - 1.96), and 2.00 (1.43 - 2.79) (p < 0.0001 for trend test), respectively. In multivariable analysis that additionally adjusted for other CHD risk factors, the association of CAC with sICAM-1 and MCP-1 was attenuated and no longer statistically significant. In African Americans, the age and gender-adjusted ORs of CAC associated with the second and third tertiles of MCP-1 compared to the first tertile were 1.16 (0.64 - 2.08) and 1.25 (0.70 - 2.23) (p = 0.44 for trend test), respectively. This result did not change materially after additional adjustment for other CHD risk factors. Test of race interaction showed that the magnitude of association between MCP-1 and CAC did not differ significantly between African Americans and whites. Similar results were obtained when CAC ≥ 10 was analyzed as an outcome for both MCP-1 and sICAM-1. Conclusion: This study suggests that sICAM-1 and MCP-1 are biomarkers of coronary atherosclerotic burden and their association with CAC was mainly driven by established CHD risk factors.

AB - Background: Data accumulated from mouse studies and in vitro studies of human arteries support the notion that soluble intercellular adhesion molecule-1 (sICAM-1) and monocyte chemoattractant protein-1 (MCP-1) play important roles in the inflammation process involved in atherosclerosis. However, at the population level, the utility of sICAM-1 and MCP-1 as biomarkers for subclinical atherosclerosis is less clear. In the follow-up exam of the NHLBI Family Heart Study, we evaluated whether plasma levels of sICAM-1 and MCP-1 were associated with coronary artery calcification (CAC), a measure of the burden of coronary atherosclerosis. Methods: CAC was measured using the Agatston score with multidetector computed tomography. Information on CAC and MCP-1 was obtained in 2246 whites and 470 African Americans (mean age 55 years) without a history of coronary heart disease (CHD). Information on sICAM-1 was obtained for white participants only. Results: In whites, after adjustment for age and gender, the odds ratios (ORs) of CAC (CAC < 0) associated with the second, third, fourth, and fifth quintiles of sICAM-1 compared to the first quintile were 1.22 (95% confidence interval [CI]: 0.91 - 1.63), 1.15 (0.84 - 1.58), 1.49 (1.09 - 2.05), and 1.72 (1.26 - 2.36) (p = 0.0005 for trend test), respectively. The corresponding ORs for the second to fifth quintiles of MCP-1 were 1.26 (0.92 - 1.73), 0.99 (0.73 - 1.34), 1.42 (1.03 - 1.96), and 2.00 (1.43 - 2.79) (p < 0.0001 for trend test), respectively. In multivariable analysis that additionally adjusted for other CHD risk factors, the association of CAC with sICAM-1 and MCP-1 was attenuated and no longer statistically significant. In African Americans, the age and gender-adjusted ORs of CAC associated with the second and third tertiles of MCP-1 compared to the first tertile were 1.16 (0.64 - 2.08) and 1.25 (0.70 - 2.23) (p = 0.44 for trend test), respectively. This result did not change materially after additional adjustment for other CHD risk factors. Test of race interaction showed that the magnitude of association between MCP-1 and CAC did not differ significantly between African Americans and whites. Similar results were obtained when CAC ≥ 10 was analyzed as an outcome for both MCP-1 and sICAM-1. Conclusion: This study suggests that sICAM-1 and MCP-1 are biomarkers of coronary atherosclerotic burden and their association with CAC was mainly driven by established CHD risk factors.

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