Association of serum myeloperoxidase with the ankle-brachial index and peripheral arterial disease

Zeenat Ali, Paul Sarcia, Thomas H. Mosley, Venkateswarlu Kondragunta, Iftikhar Jan Kullo

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Myeloperoxidase (MPO) is an enzymatic mediator of several inflammatory cascades and higher serum levels have been associated with increased risk of adverse cardiovascular events. We investigated the association of serum MPO with the ankle-brachial index (ABI) and peripheral arterial disease (PAD) in a bi-ethnic cohort of African-Americans and non-Hispanic white individuals. Participants included 1324 African-Americans (mean age 64 years, 71% women) and 1237 non-Hispanic white individuals (mean age 59 years, 57% women) belonging to hypertensive sibships. Serum levels of MPO were measured by solid phase sandwich immunoassay. ABI was measured using a standard protocol and PAD was defined as an ABI < 0.90. Multivariable regression analysis using generalized estimating equations were performed to assess whether serum MPO levels were associated with ABI and the presence of PAD. After adjustment for age and sex, higher MPO levels were significantly associated with lower ABI and the presence of PAD in African-Americans (p = 0.004 and p = 0.005, respectively) and in non-Hispanic white individuals (p = 0.001 and p = 0.016, respectively). After additional adjustment for conventional risk factors (diabetes, smoking status, total and high-density lipoprotein cholesterol, waist circumference, hypertension), prior history of myocardial infarction or stroke, and medication use (statins, aspirin, estrogen), higher MPO levels remained significantly associated with lower ABI and the presence of PAD in both African-Americans (p = 0.008 and p = 0.010, respectively) and non-Hispanic white individuals (p = 0.001 and p = 0.018, respectively). We conclude that higher MPO levels are associated with lower ABI and the presence of PAD in African-Americans and non-Hispanic white individuals.

Original languageEnglish (US)
Pages (from-to)215-220
Number of pages6
JournalVascular Medicine
Volume14
Issue number3
DOIs
StatePublished - 2009

Fingerprint

Ankle Brachial Index
Peripheral Arterial Disease
Peroxidase
African Americans
Serum
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Waist Circumference
Immunoassay
HDL Cholesterol
Aspirin
Estrogens
Smoking
Stroke
Myocardial Infarction
Regression Analysis
Hypertension

Keywords

  • Ankle-brachial index
  • Inflammation
  • Myeloperoxidase
  • Peripheral arterial disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Association of serum myeloperoxidase with the ankle-brachial index and peripheral arterial disease. / Ali, Zeenat; Sarcia, Paul; Mosley, Thomas H.; Kondragunta, Venkateswarlu; Kullo, Iftikhar Jan.

In: Vascular Medicine, Vol. 14, No. 3, 2009, p. 215-220.

Research output: Contribution to journalArticle

Ali, Zeenat ; Sarcia, Paul ; Mosley, Thomas H. ; Kondragunta, Venkateswarlu ; Kullo, Iftikhar Jan. / Association of serum myeloperoxidase with the ankle-brachial index and peripheral arterial disease. In: Vascular Medicine. 2009 ; Vol. 14, No. 3. pp. 215-220.
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