Association of genetic variation in cannabinoid mechanisms and gastric motor functions and satiation in overweight and obesity

Maria I Vazquez Roque, Michael Camilleri, Adrian Vella, P. Carlson, J. Laugen, A. R. Zinsmeister

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8 Citations (Scopus)

Abstract

Background The endocannabinoid system is associated with food intake. We hypothesized that genes regulating cannabinoids are associated with obesity. Genetic variations in fatty acid amide hydroxylase (FAAH) and cannabinoid receptor 1 (CNR1) are associated with satiation and gastric motor function. Methods In 62 overweight or obese adults of European ancestry, single nucleotide polymorphisms of rs806378 (nearest gene CNR1) and rs324420 (nearest gene FAAH) were genotyped and the associations with gastric emptying (GE) of solids and liquids, gastric volume (GV), and satiation [maximum tolerated volume (MTV) and symptoms after Ensure ® nutrient drink test] were explored using a dominant genetic model, with gender and BMI as covariates. Key Results rs806378 CC genotype was associated with reduced fasting GV (210.2±11.0mL for CC group compared to 242.5±11.3mL for CT/TT group, P=0.031) and a modest, non-significant association with GE of solids (P=0.17). rs324420 genotype was not associated with alterations in gastric motor functions; however, there was a difference in the Ensure ® MTV (1174.6±37.2mL for CC group compared to 1395.0±123.1mL for CA/AA group, P=0.046) suggesting higher satiation with CC genotype. Conclusions & Inferences Our data suggest that CNR1 and FAAH are associated with altered gastric functions or satiation that may predispose to obesity.

Original languageEnglish (US)
JournalNeurogastroenterology and Motility
Volume23
Issue number7
DOIs
StatePublished - Jul 2011

Fingerprint

Satiation
Cannabinoids
Stomach
Obesity
Cannabinoid Receptors
Mixed Function Oxygenases
Amides
Fatty Acids
Gastric Emptying
Genotype
Genes
Endocannabinoids
Genetic Models
Single Nucleotide Polymorphism
Fasting
Eating
Food

Keywords

  • Cannabinoid receptor
  • Cannabinoid receptor 1
  • Endocannabinoids
  • Fatty acid amide hydroxylase
  • Gastric emptying
  • Gastric volume

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Gastroenterology
  • Physiology

Cite this

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title = "Association of genetic variation in cannabinoid mechanisms and gastric motor functions and satiation in overweight and obesity",
abstract = "Background The endocannabinoid system is associated with food intake. We hypothesized that genes regulating cannabinoids are associated with obesity. Genetic variations in fatty acid amide hydroxylase (FAAH) and cannabinoid receptor 1 (CNR1) are associated with satiation and gastric motor function. Methods In 62 overweight or obese adults of European ancestry, single nucleotide polymorphisms of rs806378 (nearest gene CNR1) and rs324420 (nearest gene FAAH) were genotyped and the associations with gastric emptying (GE) of solids and liquids, gastric volume (GV), and satiation [maximum tolerated volume (MTV) and symptoms after Ensure {\circledR} nutrient drink test] were explored using a dominant genetic model, with gender and BMI as covariates. Key Results rs806378 CC genotype was associated with reduced fasting GV (210.2±11.0mL for CC group compared to 242.5±11.3mL for CT/TT group, P=0.031) and a modest, non-significant association with GE of solids (P=0.17). rs324420 genotype was not associated with alterations in gastric motor functions; however, there was a difference in the Ensure {\circledR} MTV (1174.6±37.2mL for CC group compared to 1395.0±123.1mL for CA/AA group, P=0.046) suggesting higher satiation with CC genotype. Conclusions & Inferences Our data suggest that CNR1 and FAAH are associated with altered gastric functions or satiation that may predispose to obesity.",
keywords = "Cannabinoid receptor, Cannabinoid receptor 1, Endocannabinoids, Fatty acid amide hydroxylase, Gastric emptying, Gastric volume",
author = "{Vazquez Roque}, {Maria I} and Michael Camilleri and Adrian Vella and P. Carlson and J. Laugen and Zinsmeister, {A. R.}",
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journal = "Neurogastroenterology and Motility",
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T1 - Association of genetic variation in cannabinoid mechanisms and gastric motor functions and satiation in overweight and obesity

AU - Vazquez Roque, Maria I

AU - Camilleri, Michael

AU - Vella, Adrian

AU - Carlson, P.

AU - Laugen, J.

AU - Zinsmeister, A. R.

PY - 2011/7

Y1 - 2011/7

N2 - Background The endocannabinoid system is associated with food intake. We hypothesized that genes regulating cannabinoids are associated with obesity. Genetic variations in fatty acid amide hydroxylase (FAAH) and cannabinoid receptor 1 (CNR1) are associated with satiation and gastric motor function. Methods In 62 overweight or obese adults of European ancestry, single nucleotide polymorphisms of rs806378 (nearest gene CNR1) and rs324420 (nearest gene FAAH) were genotyped and the associations with gastric emptying (GE) of solids and liquids, gastric volume (GV), and satiation [maximum tolerated volume (MTV) and symptoms after Ensure ® nutrient drink test] were explored using a dominant genetic model, with gender and BMI as covariates. Key Results rs806378 CC genotype was associated with reduced fasting GV (210.2±11.0mL for CC group compared to 242.5±11.3mL for CT/TT group, P=0.031) and a modest, non-significant association with GE of solids (P=0.17). rs324420 genotype was not associated with alterations in gastric motor functions; however, there was a difference in the Ensure ® MTV (1174.6±37.2mL for CC group compared to 1395.0±123.1mL for CA/AA group, P=0.046) suggesting higher satiation with CC genotype. Conclusions & Inferences Our data suggest that CNR1 and FAAH are associated with altered gastric functions or satiation that may predispose to obesity.

AB - Background The endocannabinoid system is associated with food intake. We hypothesized that genes regulating cannabinoids are associated with obesity. Genetic variations in fatty acid amide hydroxylase (FAAH) and cannabinoid receptor 1 (CNR1) are associated with satiation and gastric motor function. Methods In 62 overweight or obese adults of European ancestry, single nucleotide polymorphisms of rs806378 (nearest gene CNR1) and rs324420 (nearest gene FAAH) were genotyped and the associations with gastric emptying (GE) of solids and liquids, gastric volume (GV), and satiation [maximum tolerated volume (MTV) and symptoms after Ensure ® nutrient drink test] were explored using a dominant genetic model, with gender and BMI as covariates. Key Results rs806378 CC genotype was associated with reduced fasting GV (210.2±11.0mL for CC group compared to 242.5±11.3mL for CT/TT group, P=0.031) and a modest, non-significant association with GE of solids (P=0.17). rs324420 genotype was not associated with alterations in gastric motor functions; however, there was a difference in the Ensure ® MTV (1174.6±37.2mL for CC group compared to 1395.0±123.1mL for CA/AA group, P=0.046) suggesting higher satiation with CC genotype. Conclusions & Inferences Our data suggest that CNR1 and FAAH are associated with altered gastric functions or satiation that may predispose to obesity.

KW - Cannabinoid receptor

KW - Cannabinoid receptor 1

KW - Endocannabinoids

KW - Fatty acid amide hydroxylase

KW - Gastric emptying

KW - Gastric volume

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U2 - 10.1111/j.1365-2982.2011.01711.x

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