Abstract
Objectives: Brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) functional polymorphism has been implicated in early-onset bipolar disorder. However, results of studies are inconsistent. We aimed to further explore this association. Methods: DNA samples from the Treatment of Early Age Mania (TEAM) and Mayo Clinic Bipolar Disorder Biobank were investigated for association of rs6265 with early-onset bipolar disorder. Bipolar cases were classified as early onset if the first manic or depressive episode occurred at age ≤19 years (versus adult-onset cases at age >19 years). After quality control, 69 TEAM early-onset bipolar disorder cases, 725 Mayo Clinic bipolar disorder cases (including 189 early-onset cases), and 764 controls were included in the analysis of association, assessed with logistic regression assuming log-additive allele effects. Results: Comparison of TEAM cases with controls suggested association of early-onset bipolar disorder with the rs6265 minor allele [odds ratio (OR) = 1.55, p = 0.04]. Although comparison of early-onset adult bipolar disorder cases from the Mayo Clinic versus controls was not statistically significant, the OR estimate indicated the same direction of effect (OR = 1.21, p = 0.19). When the early-onset TEAM and Mayo Clinic early-onset adult groups were combined and compared with the control group, the association of the minor allele rs6265 was statistically significant (OR = 1.30, p = 0.04). Conclusions: These preliminary analyses of a relatively small sample with early-onset bipolar disorder are suggestive that functional variation in BDNF is implicated in bipolar disorder risk and may have a more significant role in early-onset expression of the disorder.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 645-652 |
| Number of pages | 8 |
| Journal | Bipolar Disorders |
| Volume | 17 |
| Issue number | 6 |
| DOIs | |
| State | Published - Sep 1 2015 |
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Keywords
- Association
- BDNF
- Bipolar disorder
- Brain-derived neurotrophic factor
- Early onset
- Val66Met
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
Cite this
Association of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism with early-onset bipolar disorder. / Nassan, Malik; Croarkin, Paul E; Luby, Joan L.; Veldic, Marin D; Joshi, Paramjit T.; Mcelroy, Susan L.; Post, Robert M.; Walkup, John T.; Cercy, Kelly; Geske, Jennifer R.; Wagner, Karen D.; Cuellar-Barboza, Alfredo B.; Casuto, Leah; Lavebratt, Catharina; Schalling, Martin; Jensen, Peter S.; Biernacka, Joanna M; Frye, Mark A.
In: Bipolar Disorders, Vol. 17, No. 6, 01.09.2015, p. 645-652.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism with early-onset bipolar disorder
AU - Nassan, Malik
AU - Croarkin, Paul E
AU - Luby, Joan L.
AU - Veldic, Marin D
AU - Joshi, Paramjit T.
AU - Mcelroy, Susan L.
AU - Post, Robert M.
AU - Walkup, John T.
AU - Cercy, Kelly
AU - Geske, Jennifer R.
AU - Wagner, Karen D.
AU - Cuellar-Barboza, Alfredo B.
AU - Casuto, Leah
AU - Lavebratt, Catharina
AU - Schalling, Martin
AU - Jensen, Peter S.
AU - Biernacka, Joanna M
AU - Frye, Mark A
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Objectives: Brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) functional polymorphism has been implicated in early-onset bipolar disorder. However, results of studies are inconsistent. We aimed to further explore this association. Methods: DNA samples from the Treatment of Early Age Mania (TEAM) and Mayo Clinic Bipolar Disorder Biobank were investigated for association of rs6265 with early-onset bipolar disorder. Bipolar cases were classified as early onset if the first manic or depressive episode occurred at age ≤19 years (versus adult-onset cases at age >19 years). After quality control, 69 TEAM early-onset bipolar disorder cases, 725 Mayo Clinic bipolar disorder cases (including 189 early-onset cases), and 764 controls were included in the analysis of association, assessed with logistic regression assuming log-additive allele effects. Results: Comparison of TEAM cases with controls suggested association of early-onset bipolar disorder with the rs6265 minor allele [odds ratio (OR) = 1.55, p = 0.04]. Although comparison of early-onset adult bipolar disorder cases from the Mayo Clinic versus controls was not statistically significant, the OR estimate indicated the same direction of effect (OR = 1.21, p = 0.19). When the early-onset TEAM and Mayo Clinic early-onset adult groups were combined and compared with the control group, the association of the minor allele rs6265 was statistically significant (OR = 1.30, p = 0.04). Conclusions: These preliminary analyses of a relatively small sample with early-onset bipolar disorder are suggestive that functional variation in BDNF is implicated in bipolar disorder risk and may have a more significant role in early-onset expression of the disorder.
AB - Objectives: Brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) functional polymorphism has been implicated in early-onset bipolar disorder. However, results of studies are inconsistent. We aimed to further explore this association. Methods: DNA samples from the Treatment of Early Age Mania (TEAM) and Mayo Clinic Bipolar Disorder Biobank were investigated for association of rs6265 with early-onset bipolar disorder. Bipolar cases were classified as early onset if the first manic or depressive episode occurred at age ≤19 years (versus adult-onset cases at age >19 years). After quality control, 69 TEAM early-onset bipolar disorder cases, 725 Mayo Clinic bipolar disorder cases (including 189 early-onset cases), and 764 controls were included in the analysis of association, assessed with logistic regression assuming log-additive allele effects. Results: Comparison of TEAM cases with controls suggested association of early-onset bipolar disorder with the rs6265 minor allele [odds ratio (OR) = 1.55, p = 0.04]. Although comparison of early-onset adult bipolar disorder cases from the Mayo Clinic versus controls was not statistically significant, the OR estimate indicated the same direction of effect (OR = 1.21, p = 0.19). When the early-onset TEAM and Mayo Clinic early-onset adult groups were combined and compared with the control group, the association of the minor allele rs6265 was statistically significant (OR = 1.30, p = 0.04). Conclusions: These preliminary analyses of a relatively small sample with early-onset bipolar disorder are suggestive that functional variation in BDNF is implicated in bipolar disorder risk and may have a more significant role in early-onset expression of the disorder.
KW - Association
KW - BDNF
KW - Bipolar disorder
KW - Brain-derived neurotrophic factor
KW - Early onset
KW - Val66Met
UR - http://www.scopus.com/inward/record.url?scp=84940973057&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84940973057&partnerID=8YFLogxK
U2 - 10.1111/bdi.12323
DO - 10.1111/bdi.12323
M3 - Article
C2 - 26528762
AN - SCOPUS:84940973057
VL - 17
SP - 645
EP - 652
JO - Bipolar Disorders
JF - Bipolar Disorders
SN - 1398-5647
IS - 6
ER -