TY - JOUR
T1 - Association between pathological and MRI findings in multiple sclerosis
AU - Filippi, Massimo
AU - Rocca, Maria A.
AU - Barkhof, Frederik
AU - Brück, Wolfgang
AU - Chen, Jacqueline T.
AU - Comi, Giancarlo
AU - DeLuca, Gabriele
AU - De Stefano, Nicola
AU - Erickson, Bradley J.
AU - Evangelou, Nikos
AU - Fazekas, Franz
AU - Geurts, Jeroen J.G.
AU - Lucchinetti, Claudia
AU - Miller, David H.
AU - Pelletier, Daniel
AU - Popescu, Bogdan F.Gh
AU - Lassmann, Hans
N1 - Funding Information:
Sponsors—This course was supported by an unrestricted education grant from Biogen.
PY - 2012/4
Y1 - 2012/4
N2 - The identification of pathological processes that could be targeted by therapeutic interventions is a major goal of research into multiple sclerosis (MS). Pathological assessment is the gold standard for such identification, but has intrinsic limitations owing to the limited availability of autopsy and biopsy tissue. MRI has gained a leading role in the assessment of MS because it allows doctors to obtain an ante mortem picture of the degree of CNS involvement. A number of correlative pathological and MRI studies have helped to define in vivo the pathological substrates of MS in focal lesions and normal-appearing white matter, not only in the brain, but also in the spinal cord. These studies have resulted in the identification of aspects of pathophysiology that were previously neglected, including grey matter involvement and vascular pathology. Despite these important achievements, numerous open questions still need to be addressed to resolve controversies about how the pathology of MS results in fixed neurological disability.
AB - The identification of pathological processes that could be targeted by therapeutic interventions is a major goal of research into multiple sclerosis (MS). Pathological assessment is the gold standard for such identification, but has intrinsic limitations owing to the limited availability of autopsy and biopsy tissue. MRI has gained a leading role in the assessment of MS because it allows doctors to obtain an ante mortem picture of the degree of CNS involvement. A number of correlative pathological and MRI studies have helped to define in vivo the pathological substrates of MS in focal lesions and normal-appearing white matter, not only in the brain, but also in the spinal cord. These studies have resulted in the identification of aspects of pathophysiology that were previously neglected, including grey matter involvement and vascular pathology. Despite these important achievements, numerous open questions still need to be addressed to resolve controversies about how the pathology of MS results in fixed neurological disability.
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U2 - 10.1016/S1474-4422(12)70003-0
DO - 10.1016/S1474-4422(12)70003-0
M3 - Review article
C2 - 22441196
AN - SCOPUS:84863344656
SN - 1474-4422
VL - 11
SP - 349
EP - 360
JO - The Lancet Neurology
JF - The Lancet Neurology
IS - 4
ER -