Association Between Juxtapapillary Duodenal Diverticula and Risk of Choledocholithiasis: a Systematic Review and Meta-analysis

Karn Wijarnpreecha, Panadeekarn Panjawatanan, Wuttiporn Manatsathit, Wisit Cheungpasitporn, Surakit Pungpapong, Frank J. Lukens, Patompong Ungprasert

Research output: Contribution to journalArticle

2 Scopus citations


Background/Objectives: Studies have suggested that the presence of juxtapapillary duodenal diverticula (JDD) could be a predisposing factor for choledocholithiasis. This systematic review and meta-analysis was conducted with the aims to summarize all available evidence to better characterize the risk. Methods: A literature search was performed using MEDLINE and EMBASE database from inception to January 2018. Cross-sectional studies that reported odd ratios (OR) comparing the risk of choledocholithiasis among individuals with JDD versus individuals without JDD were included. Pooled OR and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method. Results: Of 527 retrieved articles, 11 studies met our eligibility criteria and were included in analysis. We found a significant association between the presence of JDD and choledocholithiasis with the pooled OR of 2.30 (95% CI, 1.84–2.86). The statistical heterogeneity was moderate with an I2 of 60%. Conclusions: A significantly increased risk of choledocholithiasis among individuals with JDD was observed in this study.

Original languageEnglish (US)
JournalJournal of Gastrointestinal Surgery
StateAccepted/In press - Jan 1 2018



  • Choledocholithiasis
  • Common bile duct stone
  • Duodenal diverticulum
  • Meta-analysis
  • Periampullary diverticulum

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

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