Association between coronary flow reserve, left ventricular systolic function, and myocardial viability in acute myocardial infarction

Brian Bridal Løgstrup, Dan E. Høfsten, Thomas B. Christophersen, Jacob E. Møller, Hans E. Bøtker, Patricia A. Pellikka, Kenneth Egstrup

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Aims: To investigate the relationships between coronary flow reserve (CFR), left ventricular (LV) systolic function, and myocardial viability in patients with acute myocardial infarction (AMI).Methods and results: In 149 patients with a first AMI, we estimated CFR non-invasively and assessed LV systolic function with low-dose dobutamine Doppler echocardiography (LDDE), which also identified viability. Resting echocardiographic variables did not differ between patients with preserved (54.4) and low CFR (45.6). During LDDE, longitudinal LV function was decreased [9.5 cm/s (8;11.3) vs. 10.6 cm/s (8.5;12.5), P = 0.04] and end-systolic volume increased [49.5 mL (38;66) vs. 42 (31;61), P = 0.04] in patients with low compared with preserved CFR. Among 87 (58) patients with resting wall motion abnormalities, 28 met the criteria for viability. One of 53 (2) met the criteria for viability in patients with CFR ≤2 compared with 27 of 34 (79) with CFR > 2, P < 0.0001.Conclusion: Resting echocardiographic parameters were similar in patient groups. During LDDE, patients with reduced CFR had increased LV size and compromised longitudinal function of LV and were less likely to have evidence of myocardial viability.

Original languageEnglish (US)
Pages (from-to)665-670
Number of pages6
JournalEuropean Journal of Echocardiography
Volume11
Issue number8
DOIs
StatePublished - Sep 1 2010

Keywords

  • Acute myocardial infarction
  • Coronary flow reserve
  • Dobutamine stress test
  • Left ventricle
  • Microcirculation
  • Transthoracic echocardiography
  • Viability

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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