Abstract
Determining the genetic architecture of late onset Alzheimer's disease remains an important research objective. One approach to the identification of novel genetic variants contributing to the disease is the classification of biologically meaningful subgroups within the larger late-onset Alzheimer's disease phenotype. The occurrence of psychotic symptoms in patients with late-onset Alzheimer's disease may identify one such group. We attempted to establish methods for the reliable assessment of psychotic symptoms in a large, geographically dispersed collection of families, multiply affected with late onset Alzheimer's disease, who were participants in the larger National Institute on Aging Late Onset Alzheimer's Disease Family Study; and to characterize the correlates and familial aggregation of psychosis within this cohort. We found that reliable assessments of psychotic symptoms during in-person or phone interviews were readily implemented. The presence of psychosis in late onset Alzheimer's disease was significantly associated with degree of cognitive impairment, and significantly, albeit modestly, correlated with the severity of other behavioural symptoms. Psychosis significantly aggregated within late onset Alzheimer's disease families suggesting that it may identify a genetically determined subgroup. Future studies should examine the linkage and association of psychosis with genetic variation within these families.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1155-1162 |
| Number of pages | 8 |
| Journal | Brain |
| Volume | 133 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2010 |
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Keywords
- Alzheimer's disease
- Family study
- Genetics
- Psychiatric comorbidity
ASJC Scopus subject areas
- Clinical Neurology
Cite this
Assessment and familial aggregation of psychosis in Alzheimer's disease from the National institute on aging late onset Alzheimer's disease family study. / Sweet, Robert A.; Bennett, David A.; Graff Radford, Neill R; Mayeux, Richard.
In: Brain, Vol. 133, No. 4, 04.2010, p. 1155-1162.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Assessment and familial aggregation of psychosis in Alzheimer's disease from the National institute on aging late onset Alzheimer's disease family study
AU - Sweet, Robert A.
AU - Bennett, David A.
AU - Graff Radford, Neill R
AU - Mayeux, Richard
PY - 2010/4
Y1 - 2010/4
N2 - Determining the genetic architecture of late onset Alzheimer's disease remains an important research objective. One approach to the identification of novel genetic variants contributing to the disease is the classification of biologically meaningful subgroups within the larger late-onset Alzheimer's disease phenotype. The occurrence of psychotic symptoms in patients with late-onset Alzheimer's disease may identify one such group. We attempted to establish methods for the reliable assessment of psychotic symptoms in a large, geographically dispersed collection of families, multiply affected with late onset Alzheimer's disease, who were participants in the larger National Institute on Aging Late Onset Alzheimer's Disease Family Study; and to characterize the correlates and familial aggregation of psychosis within this cohort. We found that reliable assessments of psychotic symptoms during in-person or phone interviews were readily implemented. The presence of psychosis in late onset Alzheimer's disease was significantly associated with degree of cognitive impairment, and significantly, albeit modestly, correlated with the severity of other behavioural symptoms. Psychosis significantly aggregated within late onset Alzheimer's disease families suggesting that it may identify a genetically determined subgroup. Future studies should examine the linkage and association of psychosis with genetic variation within these families.
AB - Determining the genetic architecture of late onset Alzheimer's disease remains an important research objective. One approach to the identification of novel genetic variants contributing to the disease is the classification of biologically meaningful subgroups within the larger late-onset Alzheimer's disease phenotype. The occurrence of psychotic symptoms in patients with late-onset Alzheimer's disease may identify one such group. We attempted to establish methods for the reliable assessment of psychotic symptoms in a large, geographically dispersed collection of families, multiply affected with late onset Alzheimer's disease, who were participants in the larger National Institute on Aging Late Onset Alzheimer's Disease Family Study; and to characterize the correlates and familial aggregation of psychosis within this cohort. We found that reliable assessments of psychotic symptoms during in-person or phone interviews were readily implemented. The presence of psychosis in late onset Alzheimer's disease was significantly associated with degree of cognitive impairment, and significantly, albeit modestly, correlated with the severity of other behavioural symptoms. Psychosis significantly aggregated within late onset Alzheimer's disease families suggesting that it may identify a genetically determined subgroup. Future studies should examine the linkage and association of psychosis with genetic variation within these families.
KW - Alzheimer's disease
KW - Family study
KW - Genetics
KW - Psychiatric comorbidity
UR - http://www.scopus.com/inward/record.url?scp=77950799868&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950799868&partnerID=8YFLogxK
U2 - 10.1093/brain/awq001
DO - 10.1093/brain/awq001
M3 - Article
C2 - 20147454
AN - SCOPUS:77950799868
VL - 133
SP - 1155
EP - 1162
JO - Brain
JF - Brain
SN - 0006-8950
IS - 4
ER -