Assessing meaningful change in quality of life over time

A users' guide for clinicians

Mirjam A G Sprangers, Carol M. Moinpour, Timothy J. Moynihan, Donald L. Patrick, Dennis A. Revicki, Neil Aarinson, Ivan Barofsky, Rick Berzon, Amy Bonomi, Monika Bullinger, Joseph C. Cappelleri, David Cella, Dianne L. Fairclough, Carol Estwing Ferrans, Marlene H. Frost, Gordon H. Guyatt, Ron D. Hays, Patrick Marquis, Geoff Norman, David Osoba & 8 others Teresa Rummans, Charles Scott, Jeff A Sloan, Tara Symonds, Claudette Varricchio, Gilbert Wong, Albert Wu, Kathleen Wyrwich

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

The objective of this article is to help clinicians interpret trial-based quality of life (QOL) changes over time. We address a series of questions and provide guidelines that are fundamental to assessing and interpreting change. The issues addressed are as follows: (1) What are the characteristics of the population for whom changes in QOL are reported? (2) Is the QOL questionnaire reliable, valid, and responsive to change? (3) Are the timing and frequency of assessments adequate? (4) Is the study adequately powered? (5) How are multiple QOL outcomes addressed in analyses? (6) How are multiple time points handled? (7) Can alternative explanations account for the observed change or lack of observed change (eg, handling of missing data, survival differences, and changes in patient's QOL perspective over time)? and (8) How is statistical significance translated into meaningful change? These guidelines will support clinicians in reviewing the clinical trial literature, which in turn can help them use the data in the treatment decision process.

Original languageEnglish (US)
Pages (from-to)561-571
Number of pages11
JournalMayo Clinic Proceedings
Volume77
Issue number6
StatePublished - 2002

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Quality of Life
Guidelines
Population Characteristics
Clinical Trials
Survival
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sprangers, M. A. G., Moinpour, C. M., Moynihan, T. J., Patrick, D. L., Revicki, D. A., Aarinson, N., ... Wyrwich, K. (2002). Assessing meaningful change in quality of life over time: A users' guide for clinicians. Mayo Clinic Proceedings, 77(6), 561-571.

Assessing meaningful change in quality of life over time : A users' guide for clinicians. / Sprangers, Mirjam A G; Moinpour, Carol M.; Moynihan, Timothy J.; Patrick, Donald L.; Revicki, Dennis A.; Aarinson, Neil; Barofsky, Ivan; Berzon, Rick; Bonomi, Amy; Bullinger, Monika; Cappelleri, Joseph C.; Cella, David; Fairclough, Dianne L.; Ferrans, Carol Estwing; Frost, Marlene H.; Guyatt, Gordon H.; Hays, Ron D.; Marquis, Patrick; Norman, Geoff; Osoba, David; Rummans, Teresa; Scott, Charles; Sloan, Jeff A; Symonds, Tara; Varricchio, Claudette; Wong, Gilbert; Wu, Albert; Wyrwich, Kathleen.

In: Mayo Clinic Proceedings, Vol. 77, No. 6, 2002, p. 561-571.

Research output: Contribution to journalArticle

Sprangers, MAG, Moinpour, CM, Moynihan, TJ, Patrick, DL, Revicki, DA, Aarinson, N, Barofsky, I, Berzon, R, Bonomi, A, Bullinger, M, Cappelleri, JC, Cella, D, Fairclough, DL, Ferrans, CE, Frost, MH, Guyatt, GH, Hays, RD, Marquis, P, Norman, G, Osoba, D, Rummans, T, Scott, C, Sloan, JA, Symonds, T, Varricchio, C, Wong, G, Wu, A & Wyrwich, K 2002, 'Assessing meaningful change in quality of life over time: A users' guide for clinicians', Mayo Clinic Proceedings, vol. 77, no. 6, pp. 561-571.
Sprangers MAG, Moinpour CM, Moynihan TJ, Patrick DL, Revicki DA, Aarinson N et al. Assessing meaningful change in quality of life over time: A users' guide for clinicians. Mayo Clinic Proceedings. 2002;77(6):561-571.
Sprangers, Mirjam A G ; Moinpour, Carol M. ; Moynihan, Timothy J. ; Patrick, Donald L. ; Revicki, Dennis A. ; Aarinson, Neil ; Barofsky, Ivan ; Berzon, Rick ; Bonomi, Amy ; Bullinger, Monika ; Cappelleri, Joseph C. ; Cella, David ; Fairclough, Dianne L. ; Ferrans, Carol Estwing ; Frost, Marlene H. ; Guyatt, Gordon H. ; Hays, Ron D. ; Marquis, Patrick ; Norman, Geoff ; Osoba, David ; Rummans, Teresa ; Scott, Charles ; Sloan, Jeff A ; Symonds, Tara ; Varricchio, Claudette ; Wong, Gilbert ; Wu, Albert ; Wyrwich, Kathleen. / Assessing meaningful change in quality of life over time : A users' guide for clinicians. In: Mayo Clinic Proceedings. 2002 ; Vol. 77, No. 6. pp. 561-571.
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