TY - JOUR
T1 - Arterial stiffness is associated with increase in blood pressure over time in treated hypertensives
AU - Coutinho, Thais
AU - Bailey, Kent R.
AU - Turner, Stephen T.
AU - Kullo, Iftikhar J.
PY - 2014/6
Y1 - 2014/6
N2 - Arterial stiffness is associated with incident hypertension. We hypothesized that measures of arterial stiffness would predict increases in systolic (SBP), mean (MAP), and pulse pressure (PP) over time in treated hypertensives. Blood pressure (BP) was measured a mean of 8.5 ± 0.9 years apart in 414 non-Hispanic white hypertensives (mean age, 60 ± 8 years; 55% women). The average of three supine right brachial BPs was recorded. Measures of arterial stiffness, including carotid-femoral pulse wave velocity (cfPWV), aortic augmentation index (AIx), and central pulse pressure (CPP), were obtained at baseline by applanation tonometry. We performed stepwise multivariable linear regression analyses adjusting for potential confounders to assess the associations of arterial stiffness parameters with BP changes over time. SBP, MAP, and PP increased in 80% of participants. After adjustment for covariates listed, cfPWV (m/s) was associated with increases in SBP (β ± standard error [SE], 0.71 ± 0.31) and PP (β ± SE, 1.09 ± 0.27); AIx (%) was associated with increases in SBP (β ± SE, 0.23 ± 0.10) and MAP (β ± SE, 0.27 ± 0.07); and CPP (mmHg) was associated with increases in SBP (β ± SE, 0.44 ± 0.07), MAP (β ± SE, 0.24 ± 0.05), and PP (β ± SE, 0.42 ± 0.06) over time (P ≤.02 for each). In conclusion, arterial stiffness measures were associated with longitudinal increases in SBP, MAP, and PP in treated hypertensives.
AB - Arterial stiffness is associated with incident hypertension. We hypothesized that measures of arterial stiffness would predict increases in systolic (SBP), mean (MAP), and pulse pressure (PP) over time in treated hypertensives. Blood pressure (BP) was measured a mean of 8.5 ± 0.9 years apart in 414 non-Hispanic white hypertensives (mean age, 60 ± 8 years; 55% women). The average of three supine right brachial BPs was recorded. Measures of arterial stiffness, including carotid-femoral pulse wave velocity (cfPWV), aortic augmentation index (AIx), and central pulse pressure (CPP), were obtained at baseline by applanation tonometry. We performed stepwise multivariable linear regression analyses adjusting for potential confounders to assess the associations of arterial stiffness parameters with BP changes over time. SBP, MAP, and PP increased in 80% of participants. After adjustment for covariates listed, cfPWV (m/s) was associated with increases in SBP (β ± standard error [SE], 0.71 ± 0.31) and PP (β ± SE, 1.09 ± 0.27); AIx (%) was associated with increases in SBP (β ± SE, 0.23 ± 0.10) and MAP (β ± SE, 0.27 ± 0.07); and CPP (mmHg) was associated with increases in SBP (β ± SE, 0.44 ± 0.07), MAP (β ± SE, 0.24 ± 0.05), and PP (β ± SE, 0.42 ± 0.06) over time (P ≤.02 for each). In conclusion, arterial stiffness measures were associated with longitudinal increases in SBP, MAP, and PP in treated hypertensives.
KW - Hypertension
KW - augmentation index
KW - pulse pressure
KW - pulse wave velocity
UR - http://www.scopus.com/inward/record.url?scp=84903120600&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84903120600&partnerID=8YFLogxK
U2 - 10.1016/j.jash.2014.03.330
DO - 10.1016/j.jash.2014.03.330
M3 - Article
C2 - 24952654
AN - SCOPUS:84903120600
SN - 1933-1711
VL - 8
SP - 414
EP - 421
JO - Journal of the American Society of Hypertension
JF - Journal of the American Society of Hypertension
IS - 6
ER -