Arterial spin labeling perfusion cardiovascular magnetic resonance of the calf in peripheral arterial disease: Cuff occlusion hyperemia vs exercise

David Lopez, Amy W. Pollak, Craig H. Meyer, Frederick H. Epstein, Li Zhao, Arthur J. Pesch, Ronny Jiji, Jennifer R. Kay, Joseph M. DiMaria, John M. Christopher, Christopher M. Kramer

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Assessment of calf muscle perfusion requires a physiological challenge. Exercise and cuff-occlusion hyperemia are commonly used methods, but it has been unclear if one is superior to the other. We hypothesized that post-occlusion calf muscle perfusion (Cuff) with pulsed arterial spin labeling (PASL) cardiovascular magnetic resonance (CMR) at 3 Tesla (T) would yield greater perfusion and improved reproducibility compared to exercise hyperemia in studies of peripheral arterial disease (PAD). Methods: Exercise and Cuff cohorts were independently recruited. PAD patients had an ankle brachial index (ABI) between 0.4-0.9. Controls (NL) had no risk factors and ABI 0.9-1.4. Subjects exercised until exhaustion (15 NL-Ex, 15 PAD-Ex) or had a thigh cuff inflated for 5 minutes (12 NL-Cuff, 11 PAD-Cuff). Peak exercise and average cuff (Cuff<inf> mean </inf>) perfusion were compared. Six participants underwent both cuff and exercise testing. Reproducibility was tested in 8 Cuff subjects (5 NL, 3 PAD). Results: Controls had greater perfusion than PAD independent of stressor (NL-Ex 74 ± 21 vs. PAD-Ex 43 ± 10, p = 0.01; NL-Cuff<inf> mean </inf> 109 ± 39 vs. PAD-Cuff<inf> mean </inf> 34 ± 17 ml/min-100 g, p < 0.001). However, there was no difference between exercise and Cuff<inf> mean </inf> perfusion within groups (p > 0.6). Results were similar when the same subjects had the 2 stressors performed. Cuff<inf> mean </inf> had superior reproducibility (Cuff<inf> mean </inf> ICC 0.98 vs. Exercise ICC 0.87) and area under the receiver operating characteristic curve (Cuff<inf> mean </inf> 0.992 vs. Exercise 0.905). Conclusions: Cuff hyperemia differentiates PAD patients from controls, as does exercise stress. Cuff<inf> mean </inf> and exercise calf perfusion values are similar. Cuff occlusion hyperemia has superior reproducibility and thus may be the preferred stressor.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalJournal of Cardiovascular Magnetic Resonance
DOIs
StateAccepted/In press - Feb 22 2015
Externally publishedYes

Fingerprint

Peripheral Arterial Disease
Hyperemia
Magnetic Resonance Spectroscopy
Perfusion
Exercise
Ankle Brachial Index
Muscles
Thigh
ROC Curve

Keywords

  • Arterial spin labeling
  • Cardiovascular magnetic resonance
  • Cuff occlusion hyperemia
  • Perfusion
  • Peripheral arterial disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Family Practice

Cite this

Arterial spin labeling perfusion cardiovascular magnetic resonance of the calf in peripheral arterial disease : Cuff occlusion hyperemia vs exercise. / Lopez, David; Pollak, Amy W.; Meyer, Craig H.; Epstein, Frederick H.; Zhao, Li; Pesch, Arthur J.; Jiji, Ronny; Kay, Jennifer R.; DiMaria, Joseph M.; Christopher, John M.; Kramer, Christopher M.

In: Journal of Cardiovascular Magnetic Resonance, 22.02.2015, p. 1-9.

Research output: Contribution to journalArticle

Lopez, David ; Pollak, Amy W. ; Meyer, Craig H. ; Epstein, Frederick H. ; Zhao, Li ; Pesch, Arthur J. ; Jiji, Ronny ; Kay, Jennifer R. ; DiMaria, Joseph M. ; Christopher, John M. ; Kramer, Christopher M. / Arterial spin labeling perfusion cardiovascular magnetic resonance of the calf in peripheral arterial disease : Cuff occlusion hyperemia vs exercise. In: Journal of Cardiovascular Magnetic Resonance. 2015 ; pp. 1-9.
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abstract = "Background: Assessment of calf muscle perfusion requires a physiological challenge. Exercise and cuff-occlusion hyperemia are commonly used methods, but it has been unclear if one is superior to the other. We hypothesized that post-occlusion calf muscle perfusion (Cuff) with pulsed arterial spin labeling (PASL) cardiovascular magnetic resonance (CMR) at 3 Tesla (T) would yield greater perfusion and improved reproducibility compared to exercise hyperemia in studies of peripheral arterial disease (PAD). Methods: Exercise and Cuff cohorts were independently recruited. PAD patients had an ankle brachial index (ABI) between 0.4-0.9. Controls (NL) had no risk factors and ABI 0.9-1.4. Subjects exercised until exhaustion (15 NL-Ex, 15 PAD-Ex) or had a thigh cuff inflated for 5 minutes (12 NL-Cuff, 11 PAD-Cuff). Peak exercise and average cuff (Cuff mean ) perfusion were compared. Six participants underwent both cuff and exercise testing. Reproducibility was tested in 8 Cuff subjects (5 NL, 3 PAD). Results: Controls had greater perfusion than PAD independent of stressor (NL-Ex 74 ± 21 vs. PAD-Ex 43 ± 10, p = 0.01; NL-Cuff mean 109 ± 39 vs. PAD-Cuff mean 34 ± 17 ml/min-100 g, p < 0.001). However, there was no difference between exercise and Cuff mean perfusion within groups (p > 0.6). Results were similar when the same subjects had the 2 stressors performed. Cuff mean had superior reproducibility (Cuff mean ICC 0.98 vs. Exercise ICC 0.87) and area under the receiver operating characteristic curve (Cuff mean 0.992 vs. Exercise 0.905). Conclusions: Cuff hyperemia differentiates PAD patients from controls, as does exercise stress. Cuff mean and exercise calf perfusion values are similar. Cuff occlusion hyperemia has superior reproducibility and thus may be the preferred stressor.",
keywords = "Arterial spin labeling, Cardiovascular magnetic resonance, Cuff occlusion hyperemia, Perfusion, Peripheral arterial disease",
author = "David Lopez and Pollak, {Amy W.} and Meyer, {Craig H.} and Epstein, {Frederick H.} and Li Zhao and Pesch, {Arthur J.} and Ronny Jiji and Kay, {Jennifer R.} and DiMaria, {Joseph M.} and Christopher, {John M.} and Kramer, {Christopher M.}",
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T2 - Cuff occlusion hyperemia vs exercise

AU - Lopez, David

AU - Pollak, Amy W.

AU - Meyer, Craig H.

AU - Epstein, Frederick H.

AU - Zhao, Li

AU - Pesch, Arthur J.

AU - Jiji, Ronny

AU - Kay, Jennifer R.

AU - DiMaria, Joseph M.

AU - Christopher, John M.

AU - Kramer, Christopher M.

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N2 - Background: Assessment of calf muscle perfusion requires a physiological challenge. Exercise and cuff-occlusion hyperemia are commonly used methods, but it has been unclear if one is superior to the other. We hypothesized that post-occlusion calf muscle perfusion (Cuff) with pulsed arterial spin labeling (PASL) cardiovascular magnetic resonance (CMR) at 3 Tesla (T) would yield greater perfusion and improved reproducibility compared to exercise hyperemia in studies of peripheral arterial disease (PAD). Methods: Exercise and Cuff cohorts were independently recruited. PAD patients had an ankle brachial index (ABI) between 0.4-0.9. Controls (NL) had no risk factors and ABI 0.9-1.4. Subjects exercised until exhaustion (15 NL-Ex, 15 PAD-Ex) or had a thigh cuff inflated for 5 minutes (12 NL-Cuff, 11 PAD-Cuff). Peak exercise and average cuff (Cuff mean ) perfusion were compared. Six participants underwent both cuff and exercise testing. Reproducibility was tested in 8 Cuff subjects (5 NL, 3 PAD). Results: Controls had greater perfusion than PAD independent of stressor (NL-Ex 74 ± 21 vs. PAD-Ex 43 ± 10, p = 0.01; NL-Cuff mean 109 ± 39 vs. PAD-Cuff mean 34 ± 17 ml/min-100 g, p < 0.001). However, there was no difference between exercise and Cuff mean perfusion within groups (p > 0.6). Results were similar when the same subjects had the 2 stressors performed. Cuff mean had superior reproducibility (Cuff mean ICC 0.98 vs. Exercise ICC 0.87) and area under the receiver operating characteristic curve (Cuff mean 0.992 vs. Exercise 0.905). Conclusions: Cuff hyperemia differentiates PAD patients from controls, as does exercise stress. Cuff mean and exercise calf perfusion values are similar. Cuff occlusion hyperemia has superior reproducibility and thus may be the preferred stressor.

AB - Background: Assessment of calf muscle perfusion requires a physiological challenge. Exercise and cuff-occlusion hyperemia are commonly used methods, but it has been unclear if one is superior to the other. We hypothesized that post-occlusion calf muscle perfusion (Cuff) with pulsed arterial spin labeling (PASL) cardiovascular magnetic resonance (CMR) at 3 Tesla (T) would yield greater perfusion and improved reproducibility compared to exercise hyperemia in studies of peripheral arterial disease (PAD). Methods: Exercise and Cuff cohorts were independently recruited. PAD patients had an ankle brachial index (ABI) between 0.4-0.9. Controls (NL) had no risk factors and ABI 0.9-1.4. Subjects exercised until exhaustion (15 NL-Ex, 15 PAD-Ex) or had a thigh cuff inflated for 5 minutes (12 NL-Cuff, 11 PAD-Cuff). Peak exercise and average cuff (Cuff mean ) perfusion were compared. Six participants underwent both cuff and exercise testing. Reproducibility was tested in 8 Cuff subjects (5 NL, 3 PAD). Results: Controls had greater perfusion than PAD independent of stressor (NL-Ex 74 ± 21 vs. PAD-Ex 43 ± 10, p = 0.01; NL-Cuff mean 109 ± 39 vs. PAD-Cuff mean 34 ± 17 ml/min-100 g, p < 0.001). However, there was no difference between exercise and Cuff mean perfusion within groups (p > 0.6). Results were similar when the same subjects had the 2 stressors performed. Cuff mean had superior reproducibility (Cuff mean ICC 0.98 vs. Exercise ICC 0.87) and area under the receiver operating characteristic curve (Cuff mean 0.992 vs. Exercise 0.905). Conclusions: Cuff hyperemia differentiates PAD patients from controls, as does exercise stress. Cuff mean and exercise calf perfusion values are similar. Cuff occlusion hyperemia has superior reproducibility and thus may be the preferred stressor.

KW - Arterial spin labeling

KW - Cardiovascular magnetic resonance

KW - Cuff occlusion hyperemia

KW - Perfusion

KW - Peripheral arterial disease

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