Areas of Interictal Spiking Are Associated with Metabolic Dysfunction in MRI-negative Temporal Lobe Epilepsy

Jerry J. Shih, Michael P. Weisend, Jeffrey Lewine, John Sanders, Jamie Dermon, Roland Lee

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Purpose: The objective of our study was to determine noninvasively whether metabolic dysfunction is present in focal areas of interictal electrophysiologic abnormality and whether metabolic dysfunction correlates with frequency of spiking. Methods: We used a prospective, power analysis-driven, age-matched design to study 20 subjects with nonlesional temporal lobe epilepsy by using magnetoencephalography (MEG) and proton magnetic resonance spectroscopy (1H-MRS). MEG was used to localize the source area of interictal spikes. 1H-MRS measured integrated peak areas for N-acetyl compounds (NAA) and choline-containing compounds (Cho) in both hippocampi, the MEG spike zone, and the region contralateral to the MEG spike zone in all subjects. 1H-MRS was performed in seven controls. Results: Fifteen of 20 subjects had a lower NAA/Cho ratio in the MEG spike zone compared with the contralateral homologous region. NAA/Cho was significantly decreased in the MEG spike zone (p < 0.01). NAA/Cho ratios were not significantly different between the hippocampus ipsilateral and contralateral to the spike activity, or from control hippocampi. NAA/Cho ratios did not correlate with spike frequency. Conclusions: Metabolic dysfunction is present in focal areas of interictal spiking in nonlesional temporal lobe epilepsy. These findings confirm that functional abnormalities can be detected in vivo in radiographically normal-appearing cortex exhibiting abnormal excitability.

Original languageEnglish (US)
Pages (from-to)223-229
Number of pages7
JournalEpilepsia
Volume45
Issue number3
DOIs
StatePublished - Mar 2004
Externally publishedYes

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Magnetoencephalography
Temporal Lobe Epilepsy
Hippocampus
Choline
Proton Magnetic Resonance Spectroscopy

Keywords

  • EG
  • Emporal lobe epilepsy
  • Interictal spikes
  • MRS

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Areas of Interictal Spiking Are Associated with Metabolic Dysfunction in MRI-negative Temporal Lobe Epilepsy. / Shih, Jerry J.; Weisend, Michael P.; Lewine, Jeffrey; Sanders, John; Dermon, Jamie; Lee, Roland.

In: Epilepsia, Vol. 45, No. 3, 03.2004, p. 223-229.

Research output: Contribution to journalArticle

Shih, Jerry J. ; Weisend, Michael P. ; Lewine, Jeffrey ; Sanders, John ; Dermon, Jamie ; Lee, Roland. / Areas of Interictal Spiking Are Associated with Metabolic Dysfunction in MRI-negative Temporal Lobe Epilepsy. In: Epilepsia. 2004 ; Vol. 45, No. 3. pp. 223-229.
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