TY - JOUR
T1 - Are Peripherally inserted central catheters associated with increased risk of adverse events in status 1B patients awaiting transplantation on continuous intravenous milrinone?
AU - Haglund, Nicholas A.
AU - Cox, Zachary L.
AU - Lee, Jeff T.
AU - Song, Yanna
AU - Keebler, Mary E.
AU - Disalvo, Thomas G.
AU - Maltais, Simon
AU - Lenihan, Daniel J.
AU - Wigger, Mark A.
N1 - Publisher Copyright:
© 2014 Elsevier Inc. All rights reserved.
PY - 2014
Y1 - 2014
N2 - Background: Peripherally inserted central catheters (PICCs) are used to deliver continuous intravenous (IV) milrinone in stage D heart failure (HF) patients awaiting heart transplantation (HT). Methods: We retrospectively analyzed PICC adverse events (AEs) and associated cost in 129 status 1B patients from 2005 to 2012. End points were HT, left ventricular assist device (LVAD), and death. Regression analysis was used to identify AE risk factors. Results: Fifty-three PICC AEs occurred in 35 patients (27%), consisting of 48 infections, 4 thromboses, and 1 bleeding event. Median duration of PICC support was 63 (interquartile range [IQR] 34-131) days, and median time to first PICC infection was 44 (IQR 14-76) days. Among PICC infections, 9% required defibrillator removal and 30% were inactivated on the HT list for a mean of 23 6 17 days. Rate of HT, LVAD, or death was similar between groups (P >.05). Regression analysis found that a double lumen PICC was associated with a shorter time to first PICC infection (hazard ratio 7.59, 95% CI 1.97-29.23; P 5.003). Median cost per PICC infection was $10,704 (IQR $7,401-$26,083). Conclusions: PICC infections were the most frequent AEs. PICCs with >1 lumen were associated with increased risk of infection. PICC AEs accounted for increased intensive care unit admissions, HT list inactivations, and overall cost.
AB - Background: Peripherally inserted central catheters (PICCs) are used to deliver continuous intravenous (IV) milrinone in stage D heart failure (HF) patients awaiting heart transplantation (HT). Methods: We retrospectively analyzed PICC adverse events (AEs) and associated cost in 129 status 1B patients from 2005 to 2012. End points were HT, left ventricular assist device (LVAD), and death. Regression analysis was used to identify AE risk factors. Results: Fifty-three PICC AEs occurred in 35 patients (27%), consisting of 48 infections, 4 thromboses, and 1 bleeding event. Median duration of PICC support was 63 (interquartile range [IQR] 34-131) days, and median time to first PICC infection was 44 (IQR 14-76) days. Among PICC infections, 9% required defibrillator removal and 30% were inactivated on the HT list for a mean of 23 6 17 days. Rate of HT, LVAD, or death was similar between groups (P >.05). Regression analysis found that a double lumen PICC was associated with a shorter time to first PICC infection (hazard ratio 7.59, 95% CI 1.97-29.23; P 5.003). Median cost per PICC infection was $10,704 (IQR $7,401-$26,083). Conclusions: PICC infections were the most frequent AEs. PICCs with >1 lumen were associated with increased risk of infection. PICC AEs accounted for increased intensive care unit admissions, HT list inactivations, and overall cost.
KW - Heart failure
KW - Infection
KW - Inotrope
KW - Peripherally inserted central catheter
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U2 - 10.1016/j.cardfail.2014.06.004
DO - 10.1016/j.cardfail.2014.06.004
M3 - Article
C2 - 24954426
AN - SCOPUS:84926301117
SN - 1071-9164
VL - 20
SP - 630
EP - 637
JO - Journal of Cardiac Failure
JF - Journal of Cardiac Failure
IS - 9
ER -