Are first trimester nuchal septations independent risk factorsfor chromosomal anomalies?

Lauren M. MacK, Wesley Lee, Joan M. Mastrobattista, Michael A. Belfort, Ignatia B. Van Den Veyver, Alireza A. Shamshirsaz, Rodrigo Ruano, Magdalena Sanz Cortes, Andres Espinoza, Arame Thiam Diouf, Jimmy Espinoza

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Objectives-There is conflicting information regarding the role of nuchal septations during first-trimester genetic screening. This study was designed to determine whether nuchal septations are risk factors for chromosomal anomalies, independent of increased nuchal translucency (NT), in the first trimester of pregnancy. Methods-This retrospective cohort study included all women who underwent first-trimester genetic screening between November 2011 and December 2014. The 95th percentile for the NT measurement was calculated for each gestational week. A multivariable logistic regression analysis was performed to determine whether the visualization of nuchal septations was an independent risk factor for chromosomal analysis while controlling for confounding variables. P <.05 was considered significant. Results-Chromosomal abnormalities were present in 1.0% of the population (33 of 3275). The prevalence of chromosomal abnormalities was significantly higher among fetuses with nuchal septations compared to fetuses with normal NT without septations (P <.001) and those with NT above the 95th percentile without septations (P <.001). The sonographic evidence of septations was associated with high risk of chromosomal abnormalities (odds ratio, 40.0; 95% confidence interval, 9.1-174.0) after controlling for NT measurements and other confounding variables. Conclusions-Visualization of nuchal septations during first-trimester genetic screening is a powerful risk factor for chromosomal anomalies, independent of increased NT.

Original languageEnglish (US)
Pages (from-to)155-161
Number of pages7
JournalJournal of Ultrasound in Medicine
Volume36
Issue number1
DOIs
StatePublished - Jan 2017

Keywords

  • Cystic hygroma
  • First-trimester screen
  • Nuchal septations
  • Nuchal translucency
  • Obstetric ultrasound

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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    MacK, L. M., Lee, W., Mastrobattista, J. M., Belfort, M. A., Van Den Veyver, I. B., Shamshirsaz, A. A., Ruano, R., Cortes, M. S., Espinoza, A., Diouf, A. T., & Espinoza, J. (2017). Are first trimester nuchal septations independent risk factorsfor chromosomal anomalies? Journal of Ultrasound in Medicine, 36(1), 155-161. https://doi.org/10.7863/ultra.16.01066