Are certain diuretics also anticonvulsants?

Dale C. Hesdorffer, James P. Stables, W. Allen Hauser, John F. Annegers, Gregory Cascino

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

A history of diuretic use has been shown to be protective for first unprovoked seizure in adult patients. Recent animal studies suggest that certain diuretics have anticonvulsant activity. We evaluated the potential for the anticonvulsant activity of current diuretic use in a population-based, case-control study in older adults. We also tested chlorthiazide and furosemide for seizure protection in animal models of epilepsy. Concurrent medical prescription of any diuretic was protective for the development of epilepsy [odds ratio (OR) = 0.62, 95% confidence interval (CI) = 0.39-0.99]. A protective effect for current thiazide use was observed (OR = 0.53, CI = 0.31-0.90), and a protective effect for furosemide was suggested (OR = 0.44, CI = 0.1-1.9). In mice, both chlorthiazide and furosemide suppressed the occurrence of maximal electroshock-induced seizures in a dose-dependent manner. Chlorthiazide's toxic dose for 50% of animals tested (TD50) could not be achieved even with dosing as high as 1, 500mg/kg for furosemide; TD50 was 549 mg/kg. Results were similar in rats. Furosemide and chlorthiazide are protective for unprovoked seizures in an epidemiological study and in animal models. Given the potential therapeutic value for seizure control, low toxicity, and low cost, therapeutic efficacy should be explored in clinical studies.

Original languageEnglish (US)
Pages (from-to)458-462
Number of pages5
JournalAnnals of neurology
Volume50
Issue number4
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Hesdorffer, D. C., Stables, J. P., Allen Hauser, W., Annegers, J. F., & Cascino, G. (2001). Are certain diuretics also anticonvulsants? Annals of neurology, 50(4), 458-462. https://doi.org/10.1002/ana.1136