TY - JOUR
T1 - Approach to the treatment of multiple myeloma
T2 - A clash of philosophies
AU - Rajkumar, S. Vincent
AU - Gahrton, Gösta
AU - Bergsagel, P. Leif
PY - 2011/9/22
Y1 - 2011/9/22
N2 - In this Perspective, we summarize some of the most contentious issues surrounding diagnosis and treatment of myeloma. We outline how a fundamental clash of philosophies, cure versus control, may be at the heart of many of the controversies. From the very definition of the disease to risk stratification to the validity of current clinical trial endpoints, we highlight the major areas of debate and provide alternative viewpoints that have implications for trial design and interpretation, as well as clinical practice.
AB - In this Perspective, we summarize some of the most contentious issues surrounding diagnosis and treatment of myeloma. We outline how a fundamental clash of philosophies, cure versus control, may be at the heart of many of the controversies. From the very definition of the disease to risk stratification to the validity of current clinical trial endpoints, we highlight the major areas of debate and provide alternative viewpoints that have implications for trial design and interpretation, as well as clinical practice.
UR - http://www.scopus.com/inward/record.url?scp=80053111637&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053111637&partnerID=8YFLogxK
U2 - 10.1182/blood-2011-06-297853
DO - 10.1182/blood-2011-06-297853
M3 - Review article
C2 - 21791430
AN - SCOPUS:80053111637
SN - 0006-4971
VL - 118
SP - 3205
EP - 3211
JO - Blood
JF - Blood
IS - 12
ER -