Approach to salvage antiretroviral therapy in heavily antiretroviral-experienced HIV-positive adults

Zelalem Temesgen, Francesca Cainelli, Eric M. Poeschla, Stacey AR Vlahakis, Sandro Vento

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Despite dramatic declines in HIV-associated morbidity and mortality as a result of highly active antiretroviral therapy, management of heavily treatment-experienced patients remains complex and challenging. Treatment response rates with subsequent antiretroviral regimens are lower than with initial antiretroviral therapy. Additionally, increased mortality has been associated with multidrug-resistant HIV. We review data relevant to management of such patients and offer a systematic approach to constructing a salvage antiretroviral regimen.

Original languageEnglish (US)
Pages (from-to)496-507
Number of pages12
JournalLancet Infectious Diseases
Volume6
Issue number8
DOIs
StatePublished - Aug 1 2006

ASJC Scopus subject areas

  • Infectious Diseases

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