Appraising the nature of luteinizing hormone secretory events in men

J. D. Veldhuis, V. Guardabasso, A. D. Rogol, W. S. Evans, K. E. Oerter, M. L. Johnson, D. Rodbard

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

We have appraised the nature of spontaneous luteinizing hormone (LH) secretory events in normal men by analyzing immunoreactive LH concentrations in blood samples withdrawn at 5-min intervals for 24 h in eight healthy individuals. A novel discrete deconvolution algorithm was applied to determine apparent instantaneous LH secretory rates from these LH concentration series. These analyses unmasked unique attributes of spontaneous LH secretory events, which were represented as delimited momentary augmentation in endogenous LH secretory rates interspersed among intervals of relative secretory quiescence. For three different peak-detection thresholds (P = 0.02, = 0.01, and = 0.005), the frequency LH secretory episodes was significantly greater than that of LH 'pulses' judged from concentration data alone. Moreover, the total mass of LH released within discrete secretory episodes could account for ~90% of LH secreted during the day. This model of distinct, short-lived, burst-like secretion of LH has important implications for further investigations of the neuroendocrine regulation of gonadotropin secretion in humans.

Original languageEnglish (US)
Pages (from-to)E599-E605
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume252
Issue number5 (15/5)
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)

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