Applications of proteomics to lab diagnosis

Raghothama Chaerkady, Akhilesh Pandey

Research output: Chapter in Book/Report/Conference proceedingChapter

35 Scopus citations

Abstract

Detailed and comprehensive characterization of proteins is a major goal of proteomics. This goal has become more realistic today with the latest high-resolution mass spectrometers capable of faster sequencing in a high-throughput fashion and with the emergence of new techniques such as protein and peptide microarrays. A promising area for discovery is the application of these advanced mass spectrometric and other quantitative proteomic methodologies to laboratory diagnosis. This review focuses on the role of proteomics in the development of new laboratory diagnostics and the implications for routine diagnosis and monitoring of diseases.

Original languageEnglish (US)
Title of host publicationAnnual Review of Pathology
Subtitle of host publicationMechanisms of Disease
EditorsAbul Abbas, Stephen Galli, Peter Howley
Pages485-498
Number of pages14
DOIs
StatePublished - Apr 11 2008

Publication series

NameAnnual Review of Pathology: Mechanisms of Disease
Volume3
ISSN (Print)1553-4006
ISSN (Electronic)1553-4014

Keywords

  • Aptamers
  • Isotope labeling
  • Mass spectrometer
  • Peptide arrays
  • Protein arrays
  • Protein profiling

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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  • Cite this

    Chaerkady, R., & Pandey, A. (2008). Applications of proteomics to lab diagnosis. In A. Abbas, S. Galli, & P. Howley (Eds.), Annual Review of Pathology: Mechanisms of Disease (pp. 485-498). (Annual Review of Pathology: Mechanisms of Disease; Vol. 3). https://doi.org/10.1146/annurev.pathmechdis.3.121806.151419