Application of mass spectrometry-based proteomics for biomarker discovery in neurological disorders

Abhilash Venugopal, Raghothama Chaerkady, Akhilesh Pandey

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Mass spectrometry-based quantitative proteomics has emerged as a powerful approach that has the potential to accelerate biomarker discovery, both for diagnostic as well as therapeutic purposes. Proteomics has traditionally been synonymous with 2D gels but is increasingly shifting to the use of gel-free systems and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). Quantitative proteomic approaches have already been applied to investigate various neurological disorders, especially in the context of identifying biomarkers from cerebrospinal fluid and serum. This review highlights the scope of different applications of quantitative proteomics in understanding neurological disorders with special emphasis on biomarker discovery.

Original languageEnglish (US)
Pages (from-to)3-11
Number of pages9
JournalAnnals of Indian Academy of Neurology
Volume12
Issue number1
DOIs
StatePublished - Jan 1 2009

Keywords

  • Biomarkers
  • Diagnosis
  • Isotope labeling
  • Mass spectrometry

ASJC Scopus subject areas

  • Clinical Neurology

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